Patents by Inventor Nancy J. Sullivan
Nancy J. Sullivan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240117011Abstract: Disclosed are monoclonal antibodies, antigen binding fragments, and bi-specific antibodies that specifically bind a coronavirus spike protein, such as SARS-CoV-2. Also disclosed is the use of these antibodies for inhibiting a coronavirus infection, such as a SARS-CoV-2 infection. In addition, disclosed are methods for detecting a coronavirus, such as SARS-CoV-2, in a biological sample, using the disclosed antibodies.Type: ApplicationFiled: February 4, 2022Publication date: April 11, 2024Applicant: The U.S.A., as Represented by the Secretary, Department of Health and Human ServicesInventors: John Misasi, Lingshu Wang, Chaim Aryeh Schramm, John R. Mascola, Daniel Cesar Douek, Nancy J. Sullivan, Amy Ransier Henry, Tongqing Zhou, Peter D. Kwong, Wei Shi, Yi Zhang, Eun Sung Yang, Mario Roederer, Rosemarie Diana Mason, Amarendra Pegu, Julie E. Ledgerwood
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Publication number: 20240109955Abstract: Disclosed are antigen binding polypeptides and antigen binding polypeptide complexes (e.g., antibodies and antigen binding fragments thereof) having certain structural and/or functional features. Also disclosed are polynucleotides and vectors encoding such polypeptides and polypeptide complexes; host cells, pharmaceutical compositions and kits containing such polypeptides and polypeptide complexes; and methods of using such polypeptides and polypeptide complexes.Type: ApplicationFiled: June 30, 2023Publication date: April 4, 2024Inventors: Juan LI, Chi-Jen WEI, Ronnie R. WEI, Zhi-Yong YANG, John R. MASCOLA, Gary J. NABEL, John MISASI, Amarendra PEGU, Lingshu WANG, Tongqing ZHOU, Misook CHOE, Olamide K. OLONINIYI, Bingchun ZHAO, Yi ZHANG, Eun Sung YANG, Man CHEN, Kwanyee LEUNG, Wei SHI, Nancy J. SULLIVAN, Peter D. KWONG, Richard A. KOUP, Barney S. GRAHAM, Peng HE
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Patent number: 11913013Abstract: This invention provides vaccines for inducing an immune response and protection against filovirus infection for use as a preventative vaccine in humans. In particular, the invention provides chimpanzee adenoviral vectors expressing filovirus proteins from different strains of Ebolavirus (EBOV) or Marburg virus (MARV).Type: GrantFiled: July 30, 2021Date of Patent: February 27, 2024Assignee: SABIN VACCINE INSTITUTEInventors: Nancy J. Sullivan, Gary J. Nabel, Clement Asiedu, Cheng Cheng, Alfredo Nicosia, Riccardo Cortese, Virginia Ammendola, Stefano Colloca
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Publication number: 20220089694Abstract: Human monoclonal antibodies that specifically bind Ebola virus glycoprotein with nanomolar affinity are described. The monoclonal antibodies were isolated by bulk sorting of plasmablasts from a human Ebola virus vaccinee and pairing of the immunoglobulin heavy and light chain genes using emulsion PCR. The paired immunoglobulin genes were expressed using Fab yeast display to screen and characterize the antibodies. The Ebola virus-specific monoclonal antibodies can be used, for example, to diagnose and treat Ebola virus infection or Ebola virus disease in a subject.Type: ApplicationFiled: December 19, 2019Publication date: March 24, 2022Applicant: The U.S.A., as represented by the Secretary, Department of Health and Human ServicesInventors: Nancy J. Sullivan, John Misasi, Brandon Dekosky, Kendra Elizabeth Leigh
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Publication number: 20220064669Abstract: This invention provides vaccines for inducing an immune response and protection against filovirus infection for use as a preventative vaccine in humans. In particular, the invention provides chimpanzee adenoviral vectors expressing filovirus proteins from different strains of Ebolavirus (EBOV) or Marburg virus (MARV).Type: ApplicationFiled: July 30, 2021Publication date: March 3, 2022Inventors: Nancy J. Sullivan, Gary J. Nabel, Clement Asiedu, Cheng Cheng, Alfredo Nicosia, Riccardo Cortese, Virginia Ammendola, Stefano Colloca
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Publication number: 20200149069Abstract: This invention provides vaccines for inducing an immune response and protection against filovirus infection for use as a preventative vaccine in humans. In particular, the invention provides chimpanzee adenoviral vectors expressing filovirus proteins from different strains of Ebolavirus (EBOV) or Marburg virus (MARV).Type: ApplicationFiled: January 24, 2020Publication date: May 14, 2020Applicants: The Government of the United States of America as Represented by the Secretary of the Department of, GlaxoSmithKline Biologicals SAInventors: Nancy J. Sullivan, Gary J. Nabel, Clement Asiedu, Cheng Cheng, Alfredo Nicosia, Riccardo Cortese, Virginia Ammendola, Stefano Colloca
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Patent number: 10584355Abstract: This invention provides vaccines for inducing an immune response and protection against filovirus infection for use as a preventative vaccine in humans. In particular, the invention provides chimpanzee adenoviral vectors expressing filovirus proteins from different strains of Ebolavirus (EBOV) or Marburg virus (MARV).Type: GrantFiled: October 31, 2016Date of Patent: March 10, 2020Assignees: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES, GLAXOSMITHKLINE BIOLOGICALS SAInventors: Nancy J. Sullivan, Gary J Nabel, Clement Asiedu, Cheng Cheng, Alfredo Nicosia, Riccardo Cortese, Virginia Ammendola, Stefano Colloca
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Patent number: 9701718Abstract: Provided are recombinant adenovirus vectors (serotype 26 and serotype 35) encoding filovirus antigens. The adenovirus vectors can be used to induce protective immune responses against filovirus infection.Type: GrantFiled: December 14, 2011Date of Patent: July 11, 2017Assignees: Janssen Vaccines & Prevention B.V., THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, THE OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTHInventors: Nancy J. Sullivan, Gary J. Nabel, Clement Asiedu, Cheng Cheng, Maria Grazia Pau, Jaap Goudsmit
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Publication number: 20170044571Abstract: This invention provides vaccines for inducing an immune response and protection against filovirus infection for use as a preventative vaccine in humans. In particular, the invention provides chimpanzee adenoviral vectors expressing filovirus proteins from different strains of Ebolavirus (EBOV) or Marburg virus (MARV).Type: ApplicationFiled: October 31, 2016Publication date: February 16, 2017Inventors: Nancy J. Sullivan, Gary J Nabel, Clement Asiedu, Cheng Cheng, Alfredo Nicosia, Riccardo Cortese, Virginia Ammendola, Stefano Colloca
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Patent number: 9526777Abstract: This invention provides vaccines for inducing an immune response and protection against filovirus infection for use as a preventative vaccine in humans. In particular, the invention provides chimpanzee adenoviral vectors expressing filovirus proteins from different strains of Ebola virus (EBOV) or Marburg virus (MARV).Type: GrantFiled: April 15, 2011Date of Patent: December 27, 2016Assignees: The United States of America as Represented by the Department of Health and Human Services, Glaxosmithkline Biologicals SAInventors: Nancy J. Sullivan, Gary J. Nabel, Clement Asiedu, Cheng Cheng, Alfredo Nicosia, Riccardo Cortese, Virginia Ammendola, Stefano Colloca
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Publication number: 20140017278Abstract: Provided are recombinant adenovirus vectors (serotype 26 and serotype 35) encoding filovirus antigens. The adenovirus vectors can be used to induce protective immune responses against filovirus infection.Type: ApplicationFiled: December 14, 2011Publication date: January 16, 2014Inventors: Nancy J. Sullivan, Gary J. Nabel, Clement Asiedu, Cheng Cheng, Maria Grazia Pau, Jaap Goudsmit
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Publication number: 20130101618Abstract: This invention provides vaccines for inducing an immune response and protection against filovirus infection for use as a preventative vaccine in humans. In particular, the invention provides chimpanzee adenoviral vectors expressing filovirus proteins from different strains of Ebolavirus (EBOV) or Marburg virus (MARV).Type: ApplicationFiled: April 15, 2011Publication date: April 25, 2013Applicants: OKAIROS AG, TheGovernmentof the UnitedStatesof America asRepre -sentedby theSecretaryoftheDept.ofHealth&HumanSerInventors: Nancy J. Sullivan, Gary J. Nabel, Clement Asiedu, Cheng Cheng, Alfredo Nicosia, Riccardo Cortese, Virginia Ammendola, Stefano Colloca
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Publication number: 20130046560Abstract: Some embodiments may be directed to matching users, such as employees, with insurance records in an integrated database, wherein the integrated database includes a plurality of insurance records, each record being associated with a unique employee and having a plurality of fields. According to some embodiments, new employee information may be received and it may be determined that the new employee information does not qualify as a strong match with any insurance record in the integrated database. Moreover, it may be determined, based on a probabilistic pattern match of the new employee information with values in the fields of the integrated database, that the new employee information qualifies as a weak match with a particular insurance record in the integrated database.Type: ApplicationFiled: August 19, 2011Publication date: February 21, 2013Inventors: Garry Jean Theus, James L. Pabilonia, Jennifer B. Raibeck, Shawn K. Simpson, Nancy J. Sullivan
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Patent number: 8080974Abstract: The battery charge indicator provides a color-coded battery status indicator system adapted for attachment to or adjacent the battery compartment on a power tool body. The system includes a first member that is adapted for attachment to the surface of the power tool. The front face of the first member is provided with hook and loop fastener material thereon. A second member has a first face fabricated from green-colored hook and loop fastener material and an opposite, second face fabricated from red-colored hook or loop fastener material. Display of the red-colored face indicates that the battery needs recharging. Display of the green-colored face indicates that the battery is charged.Type: GrantFiled: August 18, 2010Date of Patent: December 20, 2011Inventors: Nancy J. Sullivan, Robert E. Sullivan
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Patent number: 8017130Abstract: The present invention relates to genetic vaccines for stimulating cellular and humoral immune responses in humans and other hosts, and, in particular, relates to recombinant viruses that express heterologous antigens of pathogenic viruses, in single dose form.Type: GrantFiled: November 5, 2009Date of Patent: September 13, 2011Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Gary J. Nabel, Nancy J. Sullivan, Thomas W. Geisbert, Peter B. Jahrling
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Publication number: 20110050238Abstract: The battery charge indicator provides a color-coded battery status indicator system adapted for attachment to or adjacent the battery compartment on a power tool body. The system includes a first member that is adapted for attachment to the surface of the power tool. The front face of the first member is provided with hook and loop fastener material thereon. A second member has a first face fabricated from green-colored hook and loop fastener material and an opposite, second face fabricated from red-colored hook or loop fastener material. Display of the red-colored face indicates that the battery needs recharging. Display of the green-colored face indicates that the battery is charged.Type: ApplicationFiled: August 18, 2010Publication date: March 3, 2011Inventors: NANCY J. SULLIVAN, ROBERT E. SULLIVAN
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Publication number: 20100047282Abstract: The present invention relates to genetic vaccines for stimulating cellular and humoral immune responses in humans and other hosts, and, in particular, relates to recombinant viruses that express heterologous antigens of pathogenic viruses, in single dose form.Type: ApplicationFiled: November 5, 2009Publication date: February 25, 2010Applicant: The Government of the USA as represented by the Secretary of Health and Human Services, NIHInventors: Gary J. Nabel, Nancy J. Sullivan, Thomas W. Geisbert, Peter B. Jahrling
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Patent number: 7635485Abstract: The present invention relates to genetic vaccines for stimulating cellular and humoral immune responses in humans and other hosts, and, in particular, relates to recombinant viruses that express heterologous antigens of pathogenic viruses, in single dose form.Type: GrantFiled: January 17, 2006Date of Patent: December 22, 2009Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Gary J. Nabel, Nancy J. Sullivan, Thomas W. Geisbert, Peter B. Jahrling