Patents by Inventor Nancy L. Cowger

Nancy L. Cowger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hepatocyte bioreactor system for long term culture of functional hepatocyte spheroids
    Patent number: 7939248
    Abstract: A rotating wall vessel is used as a culture vessel and bioreactor for the cultivation of hepatocytes in the form of spheroids to generate a culture with many properties of the intact liver. These properties include enzyme activity comparable to fresh cells and long-term maintenance of viability and cellular function for periods on the order of months. The cultures may be used to produce hepatocyte products, evaluate metabolism of an agent, propagate Hepatitis C virus and test agents as inhibitors of this virus. Thus, the culture system disclosed herein makes long term functional cultivation of human hepatocytes feasible.
    Type: Grant
    Filed: August 17, 2009
    Date of Patent: May 10, 2011
    Assignee: Celsis In Vitro, Inc.
    Inventors: Paul M. Silber, Nancy L. Cowger, Ana P. Miller, Lanika A. Brown, Albert P. Li
  • Hepatocyte Bioreactor System For Long Term Culture of Functional Hepatocyte Spheroids
    Publication number: 20100035298
    Abstract: A rotating wall vessel is used as a culture vessel and bioreactor for the cultivation of hepatocytes in the form of spheroids to generate a culture with many properties of the intact liver. These properties include enzyme activity comparable to fresh cells and long-term maintenance of viability and cellular function for periods on the order of months. The cultures may be used to produce hepatocyte products, evaluate metabolism of an agent, propagate Hepatitis C virus and test agents as inhibitors of this virus. Thus, the culture system disclosed herein makes long term functional cultivation of human hepatocytes feasible.
    Type: Application
    Filed: August 17, 2009
    Publication date: February 11, 2010
    Applicant: In Vitro Technologies, Inc.
    Inventors: Lanika A. Brown, Paul M. Silber, Nancy L. Cowger, Ana P. Miller, Albert P. Li
  • Hepatocyte bioreactor system for long term culture of functional hepatocyte spheroids
    Patent number: 7575859
    Abstract: A rotating wall vessel is used as a culture vessel and bioreactor for the cultivation of hepatocytes in the form of spheroids to generate a culture with many properties of the intact liver. These properties include enzyme activity comparable to fresh cells and long-term maintenance of viability and cellular function for periods on the order of months. The cultures may be used to produce hepatocyte products, evaluate metabolism of an agent, propagate Hepatitis C virus and test agents as inhibitors of this virus. Thus, the culture system disclosed herein makes long term functional cultivation of human hepatocytes feasible.
    Type: Grant
    Filed: July 21, 2008
    Date of Patent: August 18, 2009
    Inventors: Paul M. Silber, Nancy L. Cowger, Ana P. Miller, Lanika A. Brown, Albert P. Li
  • Hepatocyte bioreactor system for long term culture of functional hepatocyte spheroids
    Patent number: 7575911
    Abstract: A rotating wall vessel is used as a culture vessel and bioreactor for the cultivation of hepatocytes in the form of spheroids to generate a culture with many properties of the intact liver. These properties include enzyme activity comparable to fresh cells and long-term maintenance of viability and cellular function for periods on the order of months. The cultures may be used to produce hepatocyte products, evaluate-metabolism of an agent, propagate Hepatitis C virus and test agents as inhibitors of this virus. Thus, the culture system disclosed herein makes long term functional cultivation of human hepatocytes feasible.
    Type: Grant
    Filed: March 31, 2008
    Date of Patent: August 18, 2009
    Inventors: Paul M. Silber, Nancy L. Cowger, Ana P. Miller, Lanika A. Brown, Albert P. Li
  • Hepatocyte Bioreactor System For Long Term Culture of Functional Hepatocyte Spheroids
    Publication number: 20080286759
    Abstract: A rotating wall vessel is used as a culture vessel and bioreactor for the cultivation of hepatocytes in the form of spheroids to generate a culture with many properties of the intact liver. These properties include enzyme activity comparable to fresh cells and long-term maintenance of viability and cellular function for periods on the order of months. The cultures may be used to produce hepatocyte products, evaluate metabolism of an agent, propagate Hepatitis C virus and test agents as inhibitors of this virus. Thus, the culture system disclosed herein makes long term functional cultivation of human hepatocytes feasible.
    Type: Application
    Filed: July 21, 2008
    Publication date: November 20, 2008
    Applicant: In Vitro Technologies, Inc.
    Inventors: Lanika A. Brown, Paul M. Silber, Nancy L. Cowger, Ana P. Miller, Albert P. Li
  • Hepatocyte Bioreactor System For Long Term Culture of Functional Hepatocyte Spheroids
    Publication number: 20080274535
    Abstract: A rotating wall vessel is used as a culture vessel and bioreactor for the cultivation of hepatocytes in the form of spheroids to generate a culture with many properties of the intact liver. These properties include enzyme activity comparable to fresh cells and long-term maintenance of viability and cellular function for periods on the order of months. The cultures may be used to produce hepatocyte products, evaluate-metabolism of an agent, propagate Hepatitis C virus and test agents as inhibitors of this virus. Thus, the culture system disclosed herein makes long term functional cultivation of human hepatocytes feasible.
    Type: Application
    Filed: March 31, 2008
    Publication date: November 6, 2008
    Applicant: In Vitro Technologies, Inc.
    Inventors: Paul M. Silber, Nancy L. Cowger, Ana P. Miller, Lanika A. Brown, Albert P. Li
  • Hepatocyte bioreactor system for long term culture of functional hepatocyte spheroids
    Patent number: 7351584
    Abstract: A rotating wall vessel is used as a culture vessel and bioreactor for the cultivation of hepatocytes in the form of spheroids to generate a culture with many properties of the intact liver. These properties include enzyme activity comparable to fresh cells and long-term maintenance of viability and cellular function for periods on the order of months. The cultures may be used to produce hepatocyte products, evaluate metabolism of an agent, propagate Hepatitis C virus and test agents as inhibitors of this virus. Thus, the culture system disclosed herein makes long term functional cultivation of human hepatocytes feasible.
    Type: Grant
    Filed: February 26, 2003
    Date of Patent: April 1, 2008
    Assignee: In Vitro Technologies, Inc.
    Inventors: Paul M. Silber, Nancy L. Cowger, Ana P. Miller, Lanika A. Brown, Albert P. Li