Patents by Inventor Nancy Lane
Nancy Lane has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210395302Abstract: The present invention provides compounds and pharmaceutical compositions of peptidomimetic ligands. The peptidomimetic ligands can be conjugated with phosphonate drugs. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of osteoporosis and for the promotion of bone growth due to their specificity for the ?4?1 integrin on mesenchymal stem cells and for the surface of bone.Type: ApplicationFiled: January 11, 2021Publication date: December 23, 2021Applicant: The Regents of the University of CaliforniaInventors: Wei YAO, Ruiwu LIU, Kit S. LAM, Wenwu XIAO, Nancy LANE
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Publication number: 20210261612Abstract: The present invention provides compounds and pharmaceutical compositions of a peptidomimetic ligand, e.g. LLP2A, conjugated with a bisphosphonate drug, e.g. Alendronate. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of osteoporosis and for the promotion of bone growth due to their specificity for the ?4?1 integrin on mesenchymal stem cells and for the surface of bone.Type: ApplicationFiled: August 19, 2020Publication date: August 26, 2021Applicant: The Regents of the University of CaliforniaInventors: Kit S. Lam, Ruiwu Liu, Wei Yao, Nancy Lane
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Publication number: 20210205338Abstract: Methods of treating osteonecrosis in a subject are provided. In some embodiments, the method comprises administering to a subject having or suspected of having osteonecrosis a pharmaceutical composition comprising a conjugate of an LLP2A peptidomimetic ligand and a bisphosphonate drug. In some embodiments, the pharmaceutical composition comprises a conjugate of LLP2A and alendronate (LLP2A-Ale). In some embodiments, the method further comprises administering exogenous mesenchymal stem cells.Type: ApplicationFiled: August 18, 2020Publication date: July 8, 2021Applicant: The Regents of the University of CaliforniaInventors: Nancy Lane, Wei Yao
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Publication number: 20200369723Abstract: The present invention provides compounds and pharmaceutical compositions of a peptidomimetic ligand, e.g. LLP2A, conjugated with a bisphosphonate drug, e.g. Alendronate. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of osteoporosis and for the promotion of bone growth due to their specificity for the ?4?1 integrin on mesenchymal stem cells and for the surface of bone.Type: ApplicationFiled: December 2, 2019Publication date: November 26, 2020Applicant: The Regents of the University of CaliforniaInventors: Kit S. Lam, Ruiwu Liu, Wei Yao, Nancy Lane
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Patent number: 10703966Abstract: A chromic luminescent composition and method for fabricating the composition are disclosed. The chromic luminescent composition comprises at least one or more non-luminescent materials and one or more luminescent materials. The one or more non-luminescent materials having absorption spectra that at least partially overlap with the spectrum of incident electromagnetic radiation. The one or more luminescent materials convert at least a portion of energy of incident electromagnetic radiation to a lower energy wavelength. The one or more non-luminescent materials and the one or more luminescent materials are selected such that, when subsequently exposed to incident electromagnetic radiation, color and brightness are substantially modulated through absorption and emission as a function of incident electromagnetic radiation. Also disclosed are a chromic luminescent textile and a method for fabricating the textile.Type: GrantFiled: October 14, 2016Date of Patent: July 7, 2020Assignee: BAMBU VAULT LLCInventors: Satish Agrawal, Louis Cincotta, Edward D. Kingsley, Nancy Lane
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Patent number: 10494401Abstract: The present invention provides compounds and pharmaceutical compositions of a peptidomimetic ligand, e.g. LLP2A, conjugated with a bisphosphonate drug, e.g. Alendronate. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of osteoporosis and for the promotion of bone growth due to their specificity for the ?4?1 integrin on mesenchymal stem cells and for the surface of bone.Type: GrantFiled: December 21, 2016Date of Patent: December 3, 2019Assignee: The Regents of the University of CaliforniaInventors: Kit S. Lam, Ruiwu Liu, Wei Yao, Nancy Lane
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Publication number: 20190076448Abstract: Methods of treating osteonecrosis in a subject are provided. In some embodiments, the method comprises administering to a subject having or suspected of having osteonecrosis a pharmaceutical composition comprising a conjugate of an LLP2A peptidomimetic ligand and a bisphosphonate drug. In some embodiments, the pharmaceutical composition comprises a conjugate of LLP2A and alendronate (LLP2A-Ale). In some embodiments, the method further comprises administering exogenous mesenchymal stem cells.Type: ApplicationFiled: July 13, 2018Publication date: March 14, 2019Applicant: The Regents of the University of CaliforniaInventors: Nancy Lane, Wei Yao
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Publication number: 20170174722Abstract: The present invention provides compounds and pharmaceutical compositions of a peptidomimetic ligand, e.g. LLP2A, conjugated with a bisphosphonate drug, e.g. Alendronate. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of osteoporosis and for the promotion of bone growth due to their specificity for the ?4?1 integrin on mesenchymal stem cells and for the surface of bone.Type: ApplicationFiled: December 21, 2016Publication date: June 22, 2017Applicant: The Regents of the University of CaliforniaInventors: Kit S. Lam, Ruiwu Liu, Wei Yao, Nancy Lane
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Patent number: 9561256Abstract: The present invention provides compounds and pharmaceutical compositions of a peptidomimetic ligand, e.g. LLP2A, conjugated with a bisphosphonate drug, e.g. Alendronate. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of osteoporosis and for the promotion of bone growth due to their specificity for the ?4?1 integrin on mesenchymal stem cells and for the surface of bone.Type: GrantFiled: July 22, 2015Date of Patent: February 7, 2017Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Kit S. Lam, Ruiwu Liu, Wei Yao, Nancy Lane
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Publication number: 20170029695Abstract: A chromic luminescent composition and method for fabricating the composition are disclosed. The chromic luminescent composition comprises at least one or more non-luminescent materials and one or more luminescent materials. The one or more non-luminescent materials having absorption spectra that at least partially overlap with the spectrum of incident electromagnetic radiation. The one or more luminescent materials convert at least a portion of energy of incident electromagnetic radiation to a lower energy wavelength. The one or more non-luminescent materials and the one or more luminescent materials are selected such that, when subsequently exposed to incident electromagnetic radiation, color and brightness are substantially modulated through absorption and emission as a function of incident electromagnetic radiation. Also disclosed are a chromic luminescent textile and a method for fabricating the textile.Type: ApplicationFiled: October 14, 2016Publication date: February 2, 2017Applicant: PERFORMANCE INDICATOR, LLCInventors: Satish Agrawal, Louis Cincotta, Edward D. Kingsley, Nancy Lane
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Patent number: 9493699Abstract: A chromic luminescent composition and method for fabricating the composition are disclosed. The chromic luminescent composition comprises at least one or more non-luminescent materials and one or more luminescent materials. The one or more non-luminescent materials having absorption spectra that at least partially overlap with the spectrum of incident electromagnetic radiation. The one or more luminescent materials convert at least a portion of energy of incident electromagnetic radiation to a lower energy wavelength. The one or more non-luminescent materials and the one or more luminescent materials are selected such that, when subsequently exposed to incident electromagnetic radiation, color and brightness are substantially modulated through absorption and emission as a function of incident electromagnetic radiation. Also disclosed are a chromic luminescent textile and a method for fabricating the textile.Type: GrantFiled: December 19, 2013Date of Patent: November 15, 2016Assignee: PERFORMANCE INDICATOR, LLCInventors: Satish Agrawal, Louis Cincotta, Edward D. Kingsley, Nancy Lane
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Patent number: 9469807Abstract: A chromic luminescent composition and method for fabricating the composition are disclosed. The chromic luminescent composition comprises at least one or more non-luminescent materials and one or more luminescent materials. The one or more non-luminescent materials having absorption spectra that at least partially overlap with the spectrum of incident electromagnetic radiation. The one or more luminescent materials convert at least a portion of energy of incident electromagnetic radiation to a lower energy wavelength. The one or more non-luminescent materials and the one or more luminescent materials are selected such that, when subsequently exposed to incident electromagnetic radiation, color and brightness are substantially modulated through absorption and emission as a function of incident electromagnetic radiation. Also disclosed are a chromic luminescent textile and a method for fabricating the textile.Type: GrantFiled: May 30, 2012Date of Patent: October 18, 2016Assignee: PERFORMANCE INDICATOR, LLCInventors: Satish Agrawal, Louis Cincotta, Edward D. Kingsley, Nancy Lane
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Publication number: 20160074461Abstract: The present invention provides compounds and pharmaceutical compositions of a peptidomimetic ligand, e.g. LLP2A, conjugated with a bisphosphonate drug, e.g. Alendronate. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of osteoporosis and for the promotion of bone growth due to their specificity for the ?4?1 integrin on mesenchymal stem cells and for the surface of bone.Type: ApplicationFiled: July 22, 2015Publication date: March 17, 2016Inventors: Kit S. Lam, Ruiwu Liu, Wei Yao, Nancy Lane
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Patent number: 9119884Abstract: The present invention provides compounds and pharmaceutical compositions of a peptidomimetic ligand, e.g. LLP2A, conjugated with a bisphosphonate drug, e.g. Alendronate. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of osteoporosis and for the promotion of bone growth due to their specificity for the ?4?1 integrin on mesenchymal stem cells and for the surface of bone.Type: GrantFiled: January 19, 2012Date of Patent: September 1, 2015Assignee: The Regents of the University of CaliforniaInventors: Kit S. Lam, Ruiwu Liu, Wei Yao, Nancy Lane
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Patent number: 8846184Abstract: A chromic luminescent object comprising one or more chromic luminescent compositions incorporated into or onto one or more portions of the object, in which the one or more chromic luminescent compositions are selected such that, when subsequently exposed to incident electromagnetic radiation, at least brightness of the one or more portions of the object is substantially modulated through absorption and emission as a function of incident electromagnetic radiation is disclosed. Also disclosed are methods for fabricating the chromic luminescent object.Type: GrantFiled: March 14, 2013Date of Patent: September 30, 2014Assignee: Performance IndicatorInventors: Satish Agrawal, Louis Cincotta, Edward D. Kingsley, Nancy Lane
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Publication number: 20140103258Abstract: A chromic luminescent composition and method for fabricating the composition are disclosed. The chromic luminescent composition comprises at least one or more non-luminescent materials and one or more luminescent materials. The one or more non-luminescent materials having absorption spectra that at least partially overlap with the spectrum of incident electromagnetic radiation. The one or more luminescent materials convert at least a portion of energy of incident electromagnetic radiation to a lower energy wavelength. The one or more non-luminescent materials and the one or more luminescent materials are selected such that, when subsequently exposed to incident electromagnetic radiation, color and brightness are substantially modulated through absorption and emission as a function of incident electromagnetic radiation. Also disclosed are a chromic luminescent textile and a method for fabricating the textile.Type: ApplicationFiled: December 19, 2013Publication date: April 17, 2014Inventors: Satish Agrawal, Louis Cincotta, Edward D. Kingsley, Nancy Lane
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Publication number: 20140056855Abstract: The present invention provides compounds and pharmaceutical compositions of a peptidomimetic ligand, e.g. LLP2A, conjugated with a bisphosphonate drug, e.g. Alendronate. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of osteoporosis and for the promotion of bone growth due to their specificity for the ?4?1 integrin on mesenchymal stem cells and for the surface of bone.Type: ApplicationFiled: January 19, 2012Publication date: February 27, 2014Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Kit S. Lam, Ruiwu Liu, Wei Yao, Nancy Lane
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Publication number: 20130288075Abstract: A chromic luminescent object comprising one or more chromic luminescent compositions incorporated into or onto one or more portions of the object, in which the one or more chromic luminescent compositions are selected such that, when subsequently exposed to incident electromagnetic radiation, at least brightness of the one or more portions of the object is substantially modulated through absorption and emission as a function of incident electromagnetic radiation is disclosed. Also disclosed are methods for fabricating the chromic luminescent object.Type: ApplicationFiled: March 14, 2013Publication date: October 31, 2013Applicant: PERFORMANCE INDICATOR, LLCInventors: Satish Agrawal, Louis Cincotta, Edward D. Kingsley, Nancy Lane
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Publication number: 20130288022Abstract: A chromic luminescent composition and method for fabricating the composition are disclosed. The chromic luminescent composition comprises at least one or more non-luminescent materials and one or more luminescent materials. The one or more non-luminescent materials having absorption spectra that at least partially overlap with the spectrum of incident electromagnetic radiation. The one or more luminescent materials convert at least a portion of energy of incident electromagnetic radiation to a lower energy wavelength. The one or more non-luminescent materials and the one or more luminescent materials are selected such that, when subsequently exposed to incident electromagnetic radiation, color and brightness are substantially modulated through absorption and emission as a function of incident electromagnetic radiation. Also disclosed are a chromic luminescent textile and a method for fabricating the textile.Type: ApplicationFiled: May 30, 2012Publication date: October 31, 2013Applicant: PERFORMANCE INDICATOR, LLCInventors: Satish Agrawal, Louis Cincotta, Edward D. Kingsley, Nancy Lane