Abstract: A contact lens comprising one or more microchannels for transport of liquid through the lens is provided. The contact lens can be made by contacting a curable composition with a microfiber that is insoluble in the curable composition; curing the curable composition to provide a polymeric lens body with the microfiber embedded therein; and contacting the polymeric lens body with a solvent to dissolve the microfiber.

Abstract: The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration of treatment, such as no more than 12 weeks. In one aspect, the treatment comprises administering at least two direct acting antiviral agents to a subject with HCV infection, wherein the treatment lasts for 12 weeks and does not include administration of either interferon or ribavirin, and said at least two direct acting antiviral agents comprise (a) Compound 1 or a pharmaceutically acceptable salt thereof and (b) Compound 2 or a pharmaceutically acceptable salt thereof.

Abstract: A women's shoe includes a sole, a heel and a base strap secured to opposite sides of the shoe and positioned to extend across of the wearer's foot. Strap covers are provided in various colors, materials, shapes and decorative surface patterns. The strap covers are each removably attachable to the base straps, in covering relation thereto, and are selectively interchangeable to provide a variety of different styles and appearances, thereby allowing the same shoe to be worn with many different outfits. The shoes are provided in different sizes, heel shapes and heights to further enhance the versatility of style and appearance, ranging from formal to casual.