Patents by Inventor Nancy M. Holloway
Nancy M. Holloway has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10196603Abstract: A method of manufacturing and/or using a scaffold assembly for stem cell culture and tissue engineering applications is disclosed. The scaffold at least partially mimics a native biological environment by providing biochemical, topographical, mechanical and electrical cues by using an electroactive material. The assembly includes at least one layer of substantially aligned, electrospun polymer fiber having an operative connection for individual voltage application. A method of cell tissue engineering and/or stem cell differentiation that uses the assembly seeded with a sample of cells suspended in cell culture media, incubates and applies voltage to one or more layers, and thus produces cells and/or a tissue construct.Type: GrantFiled: August 3, 2017Date of Patent: February 5, 2019Assignee: The United States of America as represented by the Administrator of NASAInventors: Lisa A. Scott Carnell, Emilie J. Siochi, Nancy M. Holloway, Kam W. Leong, Karina Kulangara
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Publication number: 20170355954Abstract: A method of manufacturing and/or using a scaffold assembly for stem cell culture and tissue engineering applications is disclosed. The scaffold at least partially mimics a native biological environment by providing biochemical, topographical, mechanical and electrical cues by using an electroactive material. The assembly includes at least one layer of substantially aligned, electrospun polymer fiber having an operative connection for individual voltage application. A method of cell tissue engineering and/or stem cell differentiation that uses the assembly seeded with a sample of cells suspended in cell culture media, incubates and applies voltage to one or more layers, and thus produces cells and/or a tissue construct.Type: ApplicationFiled: August 3, 2017Publication date: December 14, 2017Inventors: Lisa A. Scott Carnell, Emilie J. Siochi, Nancy M. Holloway, Kam W. Leong, Karina Kulangara
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Patent number: 9758761Abstract: A method of manufacturing and/or using a scaffold assembly for stem cell culture and tissue engineering applications is disclosed. The scaffold at least partially mimics a native biological environment by providing biochemical, topographical, mechanical and electrical cues by using an electroactive material. The assembly includes at least one layer of substantially aligned, electrospun polymer fiber having an operative connection for individual voltage application. A method of cell tissue engineering and/or stem cell differentiation that uses the assembly seeded with a sample of cells suspended in cell culture media, incubates and applies voltage to one or more layers, and thus produces cells and/or a tissue construct.Type: GrantFiled: April 13, 2015Date of Patent: September 12, 2017Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space AdministrationInventors: Lisa A. Scott Carnell, Emilie J. Siochi, Nancy M. Holloway, Kam W. Leong, Karina Kulangara
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Publication number: 20150218510Abstract: A method of manufacturing and/or using a scaffold assembly for stem cell culture and tissue engineering applications is disclosed. The scaffold at least partially mimics a native biological environment by providing biochemical, topographical, mechanical and electrical cues by using an electroactive material. The assembly includes at least one layer of substantially aligned, electrospun polymer fiber having an operative connection for individual voltage application. A method of cell tissue engineering and/or stem cell differentiation that uses the assembly seeded with a sample of cells suspended in cell culture media, incubates and applies voltage to one or more layers, and thus produces cells and/or a tissue construct.Type: ApplicationFiled: April 13, 2015Publication date: August 6, 2015Inventors: Lisa A. Scott Carnell, Emilie J. Siochi, Nancy M. Holloway, Kam W. Leong, Karina Kulangara
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Patent number: 9005604Abstract: A scaffold assembly and related methods of manufacturing and/or using the scaffold for stem cell culture and tissue engineering applications are disclosed which at least partially mimic a native biological environment by providing biochemical, topographical, mechanical and electrical cues by using an electroactive material. The assembly includes at least one layer of substantially aligned, electrospun polymer fiber having an operative connection for individual voltage application. A method of cell tissue engineering and/or stem cell differentiation uses the assembly seeded with a sample of cells suspended in cell culture media, incubates and applies voltage to one or more layers, and thus produces cells and/or a tissue construct.Type: GrantFiled: December 15, 2010Date of Patent: April 14, 2015Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space AdministrationInventors: Lisa A. Scott-Carnell, Emilie J. Siochi, Nancy M. Holloway, Kam W. Leong, Karina Kulangara
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Patent number: 7993567Abstract: A method and system are provided for aligning fibers in an electrospinning process. A jet of a fiberizable material is directed towards an uncharged collector from a dispensing location that is spaced apart from the collector. While the fiberizable material is directed towards the collector, an elliptical electric field is generated via the electrically charged dispenser and an oppositely-charged control location. The field spans between the dispensing location and the control location that is within line-of-sight of the dispensing location, and impinges upon at least a portion of the collector. Various combinations of numbers and geometries of dispensers, collectors, and electrodes can be used.Type: GrantFiled: June 2, 2008Date of Patent: August 9, 2011Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space AdministrationInventors: Lisa A. Scott-Carnell, Ralph M Stephens, Nancy M. Holloway, Caroline Rhim, Laura Niklason, Robert L. Clark, Emilie J. Siochi
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Publication number: 20110142806Abstract: A scaffold assembly and related methods of manufacturing and/or using the scaffold for stem cell culture and tissue engineering applications are disclosed which at least partially mimic a native biological environment by providing biochemical, topographical, mechanical and electrical cues by using an electroactive material. The assembly includes at least one layer of substantially aligned, electrospun polymer fiber having an operative connection for individual voltage application. A method of cell tissue engineering and/or stem cell differentiation uses the assembly seeded with a sample of cells suspended in cell culture media, incubates and applies voltage to one or more layers, and thus produces cells and/or a tissue construct.Type: ApplicationFiled: December 15, 2010Publication date: June 16, 2011Applicant: USA as represented by the Administrator of the National Aeronautics and Space AdmInventors: Lisa A. Scott-Carnell, Emilie J. Siochi, Nancy M. Holloway, Kam W. Leong, Karina Kulangara
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Patent number: 7935414Abstract: An electroactive material comprises multiple layers of electroactive composite with each layer having unique dielectric, electrical and mechanical properties that define an electromechanical operation thereof when affected by an external stimulus. For example, each layer can be (i) a 2-phase composite made from a polymer with polarizable moieties and an effective amount of carbon nanotubes incorporated in the polymer for a predetermined electomechanical operation, or (ii) a 3-phase composite having the elements of the 2-phase composite and further including a third component of micro-sized to nano-sized particles of an electroactive ceramic incorporated in the polymer matrix.Type: GrantFiled: March 18, 2009Date of Patent: May 3, 2011Assignee: United States of America as represented by the Administrator of the National Aeronautics and Space AdministrationInventors: Zoubeida Ounaies, Cheol Park, Joycelyn S. Harrison, Nancy M. Holloway, Gregory K. Draughon
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Publication number: 20100068485Abstract: An electroactive material comprises multiple layers of electroactive composite with each layer having unique dielectric, electrical and mechanical properties that define an electromechanical operation thereof when affected by an external stimulus. For example, each layer can be (i) a 2-phase composite made from a polymer with polarizable moieties and an effective amount of carbon nanotubes incorporated in the polymer for a predetermined electomechanical operation, or (ii) a 3-phase composite having the elements of the 2-phase composite and further including a third component of micro-sized to nano-sized particles of an electroactive ceramic incorporated in the polymer matrix.Type: ApplicationFiled: March 18, 2009Publication date: March 18, 2010Applicant: USA as represented by the Administrator of the National Aeronautics Space AdministrationInventors: Zoubeida OUNAIES, Cheol PARK, Joycelyn S. HARRISON, Nancy M. HOLLOWAY, Gregory K. DRAUGHON
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Patent number: 7527751Abstract: An electroactive sensing or actuating material comprises a composite made from a polymer with polarizable moieties and an effective amount of carbon nanotubes incorporated in the polymer for a predetermined electromechanical operation of the composite when such composite is affected by an external stimulus. In another embodiment, the composite comprises a third component of micro-sized to nano-sized particles of an electroactive ceramic that is also incorporated in the polymer matrix. The method for making the three-phase composite comprises either incorporating the carbon nanotubes in the polymer matrix before incorporation of the particles of ceramic or mixing the carbon nanotubes and particles of ceramic together in a solution before incorporation in the polymer matrix.Type: GrantFiled: April 25, 2008Date of Patent: May 5, 2009Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space AdministrationInventors: Zoubeida Ounaies, Cheol Park, Joycelyn S. Harrison, Nancy M. Holloway, Gregory K. Draughon
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Publication number: 20090108503Abstract: A method and system are provided for aligning fibers in an electrospinning process. A jet of a fiberizable material is directed towards an uncharged collector from a dispensing location that is spaced apart from the collector. While the fiberizable material is directed towards the collector, an elliptical electric field is generated via the electrically charged dispenser and an oppositely-charged control location. The field spans between the dispensing location and the control location that is within line-of-sight of the dispensing location, and impinges upon at least a portion of the collector. Various combinations of numbers and geometries of dispensers, collectors, and electrodes can be used.Type: ApplicationFiled: June 2, 2008Publication date: April 30, 2009Applicant: USA as represented by the Administrator of the National Aeronautics and Space AdministrationInventors: Lisa A. Scott-Carnell, Ralph M. Stephens, Nancy M. Holloway, Caroline Rhim, Laura Niklason, Robert L. Clark, Emilie J. Siochi
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Patent number: 7507472Abstract: An electroactive material comprises multiple layers of electroactive composite with each layer having unique dielectric, electrical and mechanical properties that define an electromechanical operation thereof when affected by an external stimulus. For example, each layer can be (i) a 2-phase composite made from a polymer with polarizable moieties and an effective amount of carbon nanotubes incorporated in the polymer for a predetermined electomechanical operation, or (ii) a 3-phase composite having the elements of the 2-phase composite and further including a third component of micro-sized to nano-sized particles of an electroactive ceramic incorporated in the polymer matrix.Type: GrantFiled: March 9, 2005Date of Patent: March 24, 2009Assignee: The United States of America as represented by the Administator of National Aeronatics and Space AdminstrationInventors: Zoubeida Ounaies, Cheol Park, Joycelyn S. Harrison, Nancy M. Holloway, Gregory K. Draughon
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Sensing/Actuating Materials Made From Carbon Nanotube Polymer Composites and Methods for Making Same
Publication number: 20080287589Abstract: An electroactive sensing or actuating material comprises a composite made from a polymer with polarizable moieties and an effective amount of carbon nanotubes incorporated in the polymer for a predetermined electromechanical operation of the composite when such composite is affected by an external stimulus. In another embodiment, the composite comprises a third component of micro-sized to nano-sized particles of an electroactive ceramic that is also incorporated in the polymer matrix. The method for making the three-phase composite comprises either incorporating the carbon nanotubes in the polymer matrix before incorporation of the particles of ceramic or mixing the carbon nanotubes and particles of ceramic together in a solution before incorporation in the polymer matrix.Type: ApplicationFiled: April 25, 2008Publication date: November 20, 2008Applicants: Space AdministrationInventors: Zoubeida Ounaies, Cheol Park, Joycelyn S. Harrison, Nancy M. Holloway, Gregory K. Draughon -
Sensing/actuating materials made from carbon nanotube polymer composites and methods for making same
Patent number: 7402264Abstract: An electroactive sensing or actuating material comprises a composite made from a polymer with polarizable moieties and an effective amount of carbon nanotubes incorporated in the polymer for a predetermined electomechanical operation of the composite when such composite is affected by an external stimulus. In another embodiment, the composite comprises a third component of micro-sized to nano-sized particles of an electroactive ceramic that is also incorporated in the polymer matrix. The method for making the three-phase composite comprises either incorporating the carbon nanotubes in the polymer matrix before incorporation of the particles of ceramic or mixing the carbon nanotubes and particles of ceramic together in a solution before incorporation in the polymer matrix.Type: GrantFiled: March 3, 2005Date of Patent: July 22, 2008Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space AdministrationInventors: Zoubeida Ounaies, Cheol Park, Joycelyn S. Harrison, Nancy M. Holloway, Gregory K. Draughon -
Patent number: 6247369Abstract: A miniature, multi-channel, electronically scanned pressure measuring device uses electrostatically bonded silicon dies in a multi-element array. These dies are bonded at specific sites on a glass, pre-patterned substrate. Thermal data is multiplexed and recorded on each individual pressure measuring diaphragm. The device functions in a cryogenic environment without the need of heaters to keep the sensor at constant temperatures.Type: GrantFiled: January 13, 1999Date of Patent: June 19, 2001Assignee: The United States of America as represented by the Administrator of the National Aeronautics of Space AdministrationInventors: John J. Chapman, Purnell Hopson, Jr., Nancy M. Holloway