Patents by Inventor Nancy Marcus

Nancy Marcus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods to treat &agr;1-antitrypsin deficiency
    Patent number: 6656912
    Abstract: Inhibitors of glucosidase, especially those related to castanospermine, are effective in preventing or ameliorating conditions such as liver damage and emphysema that are present in individuals who produce a mutant form of antitrypsin, &agr;1-ATZ. Also effective in the method of the invention are imino sugars and their reduced forms in general as well as phenylbutyric acid. These compounds enhance the secretion of the mutant form, which retains substantial biological activity, and do not impair its degradation in the endoplasmic reticulum.
    Type: Grant
    Filed: January 22, 2001
    Date of Patent: December 2, 2003
    Assignee: Washington University in St. Louis
    Inventors: David H. Perlmutter, Nancy Marcus
  • Methods to treat alpha1-antitrypsin deficiency
    Publication number: 20020006909
    Abstract: Inhibitors of glucosidase, especially those related to castanospermine, are effective in preventing or ameliorating conditions such as liver damage and emphysema that are present in individuals who produce a mutant form of antitrypsin, &agr;1-ATZ. Also effective in the method of the invention are imino sugars and their reduced forms in general as well as phenylbutyric acid. These compounds enhance the secretion of the mutant form, which retains substantial biological activity, and do not impair its degradation in the endoplasmic reticulum.
    Type: Application
    Filed: January 22, 2001
    Publication date: January 17, 2002
    Inventors: David H. Perlmutter, Nancy Marcus