Patents by Inventor Nancy Ratner

Nancy Ratner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and Compositions for the Treatment of RAS Associated Disorders
    Publication number: 20130345268
    Abstract: The instant disclosure relates to compositions that may be useful as therapeutic agents for the treatment of disorders associated or caused by Ras deregulation or dysregulation, for example, disorders associated with alterations in the NF1 gene such as neurofibromatosis type I, fungal infections such as those caused by Candida albicans, and proliferative disorders such as glioblastoma.
    Type: Application
    Filed: August 20, 2013
    Publication date: December 26, 2013
    Applicants: The Trustees of Dartmouth College, Children's Hospital Medical Center
    Inventors: Nancy Ratner, Yolanda Sanchez, Gunnar Johansson, William Seibel
  • Methods and Compositions for the Treatment of RAS Associated Disorders
    Publication number: 20120302581
    Abstract: The instant disclosure relates to compositions that may be useful as therapeutic agents for the treatment of disorders associated or caused by Ras deregulation or dysregulation, for example, disorders associated with alterations in the NF1 gene such as neurofibromatosis type I, fungal infections such as those caused by Candida albicans, and proliferative disorders such as glioblastoma.
    Type: Application
    Filed: August 12, 2011
    Publication date: November 29, 2012
    Inventors: Nancy Ratner, Yolanda Sanchez, Gunnar Johansson, William Seibel
  • Compositions for Identifying Novel Compositions for the Treatment of Disease and Methods of Using Same
    Publication number: 20100209931
    Abstract: Disclosed herein are compositions useful for identification of potential therapeutic agents for the treatment of a disorder associated with RAS deregulation or dysregulation. The compositions may be a yeast cell having one or more mutations in an IRA gene or an ERG gene. Also disclosed are methods of using these compositions.
    Type: Application
    Filed: February 15, 2010
    Publication date: August 19, 2010
    Inventors: YOLANDA SANCHEZ, NANCY RATNER, MATTHEW DUNCAN WOOD
  • Immunohistochemical assay for ras activity
    Publication number: 20030170751
    Abstract: The present invention generally relates to methods for diagnosis and prognosis of cancers and more particularly to methods of detecting activated ras oncogene in cells and tissues. This method makes use of a fusion protein construct comprising the ras oncogene binding domain (“RBD”) of the raf protein which is linked to GST. This forms a “raf-GST” construct that binds to the ras oncogene only when ras is activated, i.e., in the ras-GTP state.
    Type: Application
    Filed: May 11, 2000
    Publication date: September 11, 2003
    Inventors: Lawrence S. Sherman, Nancy Ratner
  • Compounds useful in the treatment of neurofibromatosis
    Patent number: 6160015
    Abstract: The present invention relates to compositions useful in the treatment of benign proliferative disorder neurofibromatosis comprising a farnesyl protein transferase inhibitor. Further contained in this invention are methods of treating benign proliferative disorder neurofibromatosis in a mammal, which methods comprise administering to said mammal, a farnesyl protein transferase inhibitor.
    Type: Grant
    Filed: July 27, 1999
    Date of Patent: December 12, 2000
    Assignee: University of Cincinnati
    Inventor: Nancy Ratner