Patents by Inventor Nancy Schoenbrunner

Nancy Schoenbrunner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA polymerases and related methods
    Patent number: 9102924
    Abstract: Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. The mutant polymerases overcome the inhibitory effects by an intercalating dye. Therefore, the mutant polymerases are useful in a variety of disclosed methods in combination with an intercalating dye. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases.
    Type: Grant
    Filed: April 16, 2009
    Date of Patent: August 11, 2015
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Keith A. Bauer, Ellen Fiss, David H. Gelfand, Edward S. Smith, Shawn Suko, Olga Budker, Nancy Schoenbrunner, Susanne Stoffel, Thomas Myers
  • METHOD OF DETERMINING THE FRACTION OF FETAL DNA IN MATERNAL BLOOD USING HLA MARKERS
    Publication number: 20150203914
    Abstract: The invention comprises a method of determining the fraction of fetal DNA in maternal blood or plasma using HLA locus wherein the maternal and fetal HLA alleles are detected and quantified by clonal or digital methods.
    Type: Application
    Filed: May 9, 2014
    Publication date: July 23, 2015
    Applicant: Roche Molecular Systems
    Inventors: Henry Erlich, Bryan Hoglund, Cherie Holcomb, Priscilla Moonsamy, Nick Newton, Melinda Rastrou, Nancy Schoenbrunner, Alison Tsan
  • Method For Coding Of Multiple PCR Reactions For Assay Recognition
    Publication number: 20150176060
    Abstract: The present invention provides for methods and compositions that use fluorescent dyes for the identification of reagents and solutions that are used to perform PCR assays.
    Type: Application
    Filed: December 8, 2014
    Publication date: June 25, 2015
    Inventors: Amar Gupta, Nancy Schoenbrunner, Kevin Janssen, Nicolas Newton
  • METHOD FOR SCREENING REAGENTS USED IN PCR ASSAYS
    Publication number: 20150176061
    Abstract: The present invention relates to methods for screening of reagents used in the performance of polymerase chain reaction (PCR) assays. The invention has applications for genotyping, pathogen detection and in vitro diagnostics.
    Type: Application
    Filed: December 11, 2014
    Publication date: June 25, 2015
    Inventors: Concordio Anacleto, Nancy Schoenbrunner
  • Methods for the Enrichment of Mutated Nucleic Acid from a Mixture
    Publication number: 20150147760
    Abstract: The detection of the presence of rare somatic mutations from a biological sample is often challenging due to the simultaneous presence of a vast excess of wild-type DNA. The present invention describes methods that would allow the enrichment of mutant DNA by depleting amplifiable wild-type DNA.
    Type: Application
    Filed: November 19, 2014
    Publication date: May 28, 2015
    Inventors: Amar Gupta, Nancy Schoenbrunner, Kevin Janssen
  • NON-INVASIVE EARLY DETECTION OF SOLID ORGAN TRANSPLANT REJECTION BY QUANTITATIVE ANALYSIS OF MIXTURES BY DEEP SEQUENCING OF HLA GENE AMPLICONS USING NEXT GENERATION SYSTEMS
    Publication number: 20140336056
    Abstract: The invention is a method of detecting or assessing solid organ graft (transplant) rejection by detecting donor-specific HLA alleles in a blood sample of a graft (transplant) recipient. The invention further comprises a method of detecting the presence of maternal cells in a blood sample of an offspring.
    Type: Application
    Filed: May 8, 2014
    Publication date: November 13, 2014
    Applicants: Roche Molecular Systems, The Scripps Research Institute
    Inventors: Henry Erlich, Bryan Hoglund, Cherie Holcomb, Priscilla Moonsamy, Nick Newton, Melinda Rastrou, Nancy Schoenbrunner, Alison Tsan, Daniel Salomon
  • Compounds and Methods for the Enrichment of Mutated Nucleic Acid from a Mixture
    Publication number: 20140308664
    Abstract: The detection of the presence of rare somatic mutations from a biological sample is often challenging due to the simultaneous presence of a vast excess of wild-type DNA. The present invention describes novel compounds and methods that would allow the enrichment of mutant DNA by depleting amplifiable wild-type DNA.
    Type: Application
    Filed: December 6, 2013
    Publication date: October 16, 2014
    Applicant: Roche Molecular Systems, Inc.
    Inventors: Amar Gupta, Nancy Schoenbrunner
  • Labeled Oligonucleotide Probes Used for Nucleic Acid Sequence Analysis
    Publication number: 20140178877
    Abstract: The present invention is directed to methods for generating a labeled oligonucleotide probe that contains a fluorescent rhodamine-derived dye for use in PCR reactions to detect a target nucleic acid.
    Type: Application
    Filed: December 6, 2013
    Publication date: June 26, 2014
    Applicant: Roche Molecular Systems, Inc.
    Inventors: Concordio Anacleto, Teodorica Bugawan, Nancy Schoenbrunner
  • Primers with Modified Phosphate and Base in Allele-Specific PCR
    Publication number: 20140170650
    Abstract: The present invention includes a method of allele-specific amplification, utilizing an allele-specific oligonucleotide, at least partially complementary to more than one variant of the target sequence, but having at least one selective nucleotide complementary to only one variant of the target sequence and incorporating both a nucleotide with a base covalently modified at the exocyclic amino group and a modified phosphate.
    Type: Application
    Filed: November 27, 2013
    Publication date: June 19, 2014
    Applicant: Roche Molecular Systems, Inc.
    Inventors: Stefanie Froehner, Dieter Heindl, Dirk Kessler, Nancy Schoenbrunner, Alison Tsan
  • HEV Assay
    Publication number: 20130280697
    Abstract: A method of simultaneously amplifying genotypes 1, 2, 3 and/or 4 of HEV is disclosed comprising amplifying the genotypes 1, 2, 3 and/or 4 of HEV with one single none-degenerate forward primer partially overlapping the 5?UTR region of HEV and at least one reverse primer. Also disclosed are related methods comprising a probe, and kits for the detection of genotypes 1, 2, 3 and/or 4 of HEV.
    Type: Application
    Filed: April 17, 2013
    Publication date: October 24, 2013
    Applicant: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Hermann Leying, Thomas W. Myers, Nicolas Newton, Eberhard Russmann, Joseph San Filippo, Nancy Schoenbrunner, Heike Wilts, Xiaoning Wu, Karen K. Y. Young, Dirk Zimmermann
  • GENERIC PCR
    Publication number: 20120190008
    Abstract: The present invention provides a method for the amplification of at least a first and a second target nucleic acid that may be present in a fluid sample. The invention further provides a kit and an analytical system for carrying out said amplification.
    Type: Application
    Filed: July 27, 2011
    Publication date: July 26, 2012
    Applicant: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Meike Eickhoff, Niclas Hitziger, Anke Mussmann, Thomas W. Myers, Christopher Newhouse, Nicolas Newton, John Niemiec, Nancy Schoenbrunner, Edward S. Smith, Stephen G. Will, Heike Wilts, Dirk Zimmermann
  • Methods and Compositions for Detecting Mutation in the Human Epidermal Growth Factor Receptor Gene
    Publication number: 20120164641
    Abstract: The invention comprises reagents and methods for detecting cancer-causing mutations in the human EGFR gene. Further, a method of detecting the mutations and a method of treatment are disclosed.
    Type: Application
    Filed: December 13, 2011
    Publication date: June 28, 2012
    Applicant: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Keith Bauer, Nancy Schoenbrunner, Alison Tsan
  • DNA POLYMERASES AND RELATED METHODS
    Publication number: 20090280539
    Abstract: Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. The mutant polymerases overcome the inhibitory effects by an intercalating dye. Therefore, the mutant polymerases are useful in a variety of disclosed methods in combination with an intercalating dye. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases.
    Type: Application
    Filed: April 16, 2009
    Publication date: November 12, 2009
    Applicant: Roche Molecular Systems, Inc.
    Inventors: Keith A. Bauer, Ellen Fiss, David H. Gelfand, Edward S. Smith, Shawn Suko, Olga Budker, Nancy Schoenbrunner, Susanne Stoffel
  • SENP1 as a marker for cancer
    Publication number: 20060014171
    Abstract: The present invention provides methods of detecting cancer cells by detecting the quantity of SENP1 and/or telomerase in a sample.
    Type: Application
    Filed: May 2, 2005
    Publication date: January 19, 2006
    Applicant: Roche Molecular Systems, Inc.
    Inventors: Cherie Holcomb, Russell Higuchi, Nancy Schoenbrunner