Patents by Inventor Nancy Sullivan

Nancy Sullivan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Neutralizing antibodies to ebola virus glycoprotein and their use
    Patent number: 11976109
    Abstract: Antibodies and antigen binding fragments that specifically bind to ebolavirus glycoprotein and neutralize ebolavirus infection are disclosed. Nucleic acids encoding these antibodies, vectors, and host cells are also provided. The disclosed antibodies, antigen binding fragments, nucleic acids and vectors can be used, for example, to inhibit an ebolavirus infection in a subject.
    Type: Grant
    Filed: December 31, 2018
    Date of Patent: May 7, 2024
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Nancy Sullivan, Kendra Leigh, John Misasi, Alberto Cagigi
  • Electrical coupling of pulse transit time (PTT) measurement system to heart for blood pressure measurement
    Patent number: 11918324
    Abstract: A pulse transit time is measured non-invasively and used to calculate a blood pressure value. A method of determining one or more blood pressure values includes propagating an alternating drive current through a thorax of a subject via electrodes located on a wrist-worn device. Resulting voltage levels of the subject are sensed by the wrist-worn device. The voltage levels are processed to detect when a volume of blood is ejected from the left ventricle. Output from a pulse arrival sensor coupled to the wrist-worn device is processed to detect when a blood pressure pulse generated by ejection of the volume of blood from the left ventricle arrives at the wrist. A pulse transit time (PTT) for transit of the blood pressure pulse from the left ventricle to the wrist is calculated. One or more blood pressure values for the subject are determined based on the PTT.
    Type: Grant
    Filed: August 11, 2020
    Date of Patent: March 5, 2024
    Assignee: Apple Inc.
    Inventors: Thomas J. Sullivan, Wren Nancy Dougherty, Richard C. Kimoto, Erno Klaassen, Ravi K. Narasimhan, Stephen J. Waydo, Todd K. Whitehurst, Derek Park-Shing Young, Santiago Quijano, Zijing Zeng
  • NEUTRALIZING ANTIBODIES TO EBOLA VIRUS GLYCOPROTEIN AND THEIR USE
    Publication number: 20210079067
    Abstract: Antibodies and antigen binding fragments that specifically bind to ebolavirus glycoprotein and neutralize ebolavirus infection are disclosed. Nucleic acids encoding these antibodies, vectors, and host cells are also provided. The disclosed antibodies, antigen binding fragments, nucleic acids and vectors can be used, for example, to inhibit an ebolavirus infection in a subject.
    Type: Application
    Filed: December 31, 2018
    Publication date: March 18, 2021
    Applicant: The U.S.A., as represented by the Secretary, Department of Health and Human Services
    Inventors: Nancy Sullivan, Kendra Leigh, John Misasi, Alberto Cagigi
  • Neutralizing antibodies to Ebola virus glycoprotein and their use
    Patent number: 10273288
    Abstract: Neutralizing antibodies and antigen binding fragments that specifically bind to Ebola virus glycoprotein are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting Ebola virus using the antibodies and antigen binding fragments are disclosed. The antibodies, antigen binding fragments, nucleic acids, and vectors, can be used, for example, to prevent and/or treat Ebola virus infection in a subject.
    Type: Grant
    Filed: November 14, 2018
    Date of Patent: April 30, 2019
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Institute for Research in Biomedicine, The United States of America, as represented by the Secretary of the Army, Humabs Biomed SA
    Inventors: Nancy Sullivan, Sabue Mulangu, Davide Corti, Antonio Lanzavecchia, Barney Graham, Jean-Jacques Muyembe-Tamfun, John Trefry, Julie Ledgerwood, Daphne Stanley
  • NEUTRALIZING ANTIBODIES TO EBOLA VIRUS GLYCOPROTEIN AND THEIR USE
    Publication number: 20190071489
    Abstract: Neutralizing antibodies and antigen binding fragments that specifically bind to Ebola virus glycoprotein are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting Ebola virus using the antibodies and antigen binding fragments are disclosed. The antibodies, antigen binding fragments, nucleic acids, and vectors, can be used, for example, to prevent and/or treat Ebola virus infection in a subject.
    Type: Application
    Filed: November 14, 2018
    Publication date: March 7, 2019
    Applicants: The U.S.A., as represented by the Secretary, Department of Health and Human Services, Institute for Research in Biomedicine, The Government of the United States, as represented by the Secretary of the Army, Humabs BioMed SA
    Inventors: Nancy Sullivan, Sabue Malangu, Davide Corti, Antonio Lanzavecchia, Barney Graham, Jean-Jacques Muyembe-Tamfun, John Trefry, Julie Ledgerwood, Daphne Stanley
  • Neutralizing antibodies to Ebola virus glycoprotein and their use
    Patent number: 10160795
    Abstract: Neutralizing antibodies and antigen binding fragments that specifically bind to Ebola virus glycoprotein are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting Ebola virus using the antibodies and antigen binding fragments are disclosed. The antibodies, antigen binding fragments, nucleic acids, and vectors, can be used, for example, to prevent and/or treat Ebola virus infection in a subject.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: December 25, 2018
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Institute for Research in Biomedicine, The United States of America as represented by the Secretary of the Army, Humabs BioMed SA
    Inventors: Nancy Sullivan, Sabue Mulangu, Davide Corti, Antonio Lanzavecchia, Barney Graham, Jean-Jacques Muyembe-Tamfun, John Trefry, Julie Ledgerwood, Daphne Stanley
  • NEUTRALIZING ANTIBODIES TO EBOLA VIRUS GLYCOPROTEIN AND THEIR USE
    Publication number: 20180291088
    Abstract: Neutralizing antibodies and antigen binding fragments that specifically bind to Ebola virus glycoprotein are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting Ebola virususing the antibodies and antigen binding fragments are disclosed. The antibodies, antigen binding fragments, nucleic acids, and vectors, can be used, for example, to prevent and/or treat Ebola virusinfection in a subject.
    Type: Application
    Filed: November 13, 2015
    Publication date: October 11, 2018
    Applicants: The U.S.A., as represented by the Secretary, Department of Health and Human Services, Institute for Research in Biomedicine, The Government of the United States as represented by the Secretary of the Army, Humabs BioMed SA
    Inventors: Nancy Sullivan, Sabue Mulangu, Davide Corti, Antonio Lanzavecchia, Barney Graham, Jean-Jacques Muyembe-Tamfun, John Trefry, Julie Ledgerwood, Daphne Stanley
  • Nucleic acids encoding modified Ebola virus glycoproteins with diminished cytotoxicity while retaining native antigenic structures
    Patent number: 9012618
    Abstract: The invention is related to a nucleic acid molecule comprising a polynucleotide encoding a modified filovirus glycoprotein (GP) having at least one amino acid change located in a relatively conserved region of said GP that decreases in vitro cytotoxicity and retains immunogenicity when compared to in vitro cytotoxicity and immunogenicity of a wild type filovirus GP, and related modified filovirus GPs, plasmid DNAs, recombinant viruses, adenoviruses, pharmaceutical compositions, vaccine compositions, antibodies that are specifically reactive with the modified filovirus GPs, and related methods of making and using the same.
    Type: Grant
    Filed: January 13, 2012
    Date of Patent: April 21, 2015
    Assignee: The United States of America as Represented by the Secretary of the Department of Health and Human Services
    Inventors: Nancy Sullivan, Bimal Chakrabarti, Zhi-Yong Yang, Maria Grazia Pau, Jaap Goudsmit, Gary Nabel
  • APPARATUS FOR REMOVING ICE AND SNOW FROM THE ROOF OF A VEHICLE
    Publication number: 20120193338
    Abstract: An electrical apparatus for removing ice and snow from the exterior top surface of the roof of a vehicle comprises at least one electrical heating element disposed against, and in direct contact with, the interior bottom surface of the roof. The heating element may be installed by the vehicle manufacturer or may be retrofit, and in the case of an automobile having a roof liner, the heating element is disposed below and in contact with the roof, but above the liner. Current to the heating element may be controlled by the vehicle's rear window defogger switch, through a relay.
    Type: Application
    Filed: January 27, 2012
    Publication date: August 2, 2012
    Inventors: Nancy A. Sullivan, Nicholas Minicucci, JR., Frank Holtham, JR., Donald R. Phillips
  • OPTIMIZED VACCINES TO PROVIDE PROTECTION AGAINST EBOLA AND OTHER VIRUSES
    Publication number: 20120156239
    Abstract: The invention is related to a nucleic acid molecule comprising a polynucleotide encoding a modified filovirus glycoprotein (GP) having at least one amino acid change located in a relatively conserved region of said GP that decreases in vitro cytotoxicity and retains immunogenicity when compared to in vitro cytotoxicity and immunogenicity of a wild type filovirus GP, and related modified filovirus GPs, plasmid DNAs, recombinant viruses, adenoviruses, pharmaceutical compositions, vaccine compositions, antibodies that are specifically reactive with the modified filovirus GPs, and related methods of making and using the same.
    Type: Application
    Filed: January 13, 2012
    Publication date: June 21, 2012
    Inventors: Nancy Sullivan, Bimal Chakrabarti, Zhi-Yong Yang, Maria Grazia Pau, Jaap Goudsmit, Gary Nabel
  • Development of a preventive vaccine for filovirus infection in primates
    Patent number: 8124592
    Abstract: The present invention relates generally to viral vaccines and, more specifically, to filovirus vaccines and methods of eliciting an immune response against a filovirus or disease caused by infection with filovirus.
    Type: Grant
    Filed: November 4, 2009
    Date of Patent: February 28, 2012
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Gary J. Nabel, Zhi-yong Yang, Nancy Sullivan, Anthony Sanchez
  • Development of a preventive vaccine for filovirus infection in primates
    Patent number: 8106027
    Abstract: The present invention relates generally to viral vaccines and, more specifically, to filovirus vaccines and methods of eliciting an immune response against a filovirus or disease caused by infection with filovirus.
    Type: Grant
    Filed: November 4, 2009
    Date of Patent: January 31, 2012
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Gary J. Nabel, Zhi-yong Yang, Nancy Sullivan, Anthony Sanchez
  • Development of a preventive vaccine for filovirus infection in primates
    Patent number: 8106026
    Abstract: The present invention relates generally to viral vaccines and, more specifically, to filovirus vaccines and methods of eliciting an immune response against a filovirus or disease caused by infection with filovirus.
    Type: Grant
    Filed: November 4, 2009
    Date of Patent: January 31, 2012
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Gary J. Nabel, Zhi-yong Yang, Nancy Sullivan, Anthony Sanchez
  • Recombinant expression vectors comprising a human codon-optimized marburg virus (MARV) angola glycoprotein gene insert and method of immunization employing said vector
    Patent number: 8101739
    Abstract: The invention is related to a nucleic acid molecule comprising a polynucleotide encoding a modified filovirus glycoprotein (GP) having at least one amino acid change located in a relatively conserved region of said GP that decreases in vitro cytotoxicity and retains immunogenicity when compared to in vitro cytotoxicity and immunogenicity of a wild type filovirus GP, and related modified filovirus GPs, plasmid DNAs, recombinant viruses, adenoviruses, pharmaceutical compositions, vaccine compositions, antibodies that are specifically reactive with the modified filovirus GPs, and related methods of making and using the same.
    Type: Grant
    Filed: September 27, 2005
    Date of Patent: January 24, 2012
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Nancy Sullivan, Bimal Chakrabarti, Zhi-Yong Yang, Maria Grazia Pau, Jaap Goudsmit, Gary Nabel
  • DEVELOPMENT OF A PREVENTIVE VACCINE FOR FILOVIRUS INFECTION IN PRIMATES
    Publication number: 20100303857
    Abstract: The present invention relates generally to viral vaccines and, more specifically, to filovirus vaccines and methods of eliciting an immune response against a filovirus or disease caused by infection with filovirus.
    Type: Application
    Filed: November 4, 2009
    Publication date: December 2, 2010
    Applicant: Health and Human Services, the Government of the U.S.A. as Represented by the Secretary, Department
    Inventors: Gary J. Nabel, Zhi-yong Yang, Nancy Sullivan, Anthony Sanchez
  • DEVELOPMENT OF A PREVENTIVE VACCINE FOR FILOVIRUS INFECTION IN PRIMATES
    Publication number: 20100297171
    Abstract: The present invention relates generally to viral vaccines and, more specifically, to filovirus vaccines and methods of eliciting an immune response against a filovirus or disease caused by infection with filovirus.
    Type: Application
    Filed: November 4, 2009
    Publication date: November 25, 2010
    Applicants: Health and Human Services, the Government of the United States of America as Represented by the Sec, Secretary, Department of
    Inventors: Gary J. Nabel, Zhi-yong Yang, Nancy Sullivan, Anthony Sanchez
  • DEVELOPMENT OF A PREVENTIVE VACCINE FOR FILOVIRUS INFECTION IN PRIMATES
    Publication number: 20100298414
    Abstract: The present invention relates generally to viral vaccines and, more specifically, to filovirus vaccines and methods of eliciting an immune response against a filovirus or disease caused by infection with filovirus.
    Type: Application
    Filed: November 4, 2009
    Publication date: November 25, 2010
    Applicants: the Secretary, Department of
    Inventors: Gary J. Nabel, Zhi-yong Yang, Nancy Sullivan, Anthony Sanchez
  • Development of a preventive vaccine for filovirus infection in primates
    Patent number: 7635688
    Abstract: The present invention relates generally to viral vaccines and, more particularly, to filovirus vaccines and methods of eliciting an immune response against a filovirus or disease caused by infection with filovirus.
    Type: Grant
    Filed: September 24, 2002
    Date of Patent: December 22, 2009
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Gary J. Nabel, Zhi-yong Yang, Nancy Sullivan, Anthony Sanchez
  • Optimzed vaccines to provide protection against ebola and other viruses
    Publication number: 20090232841
    Abstract: The invention is related to a nucleic acid molecule comprising a polynucleotide encoding a modified filovirus glycoprotein (GP) having at least one amino acid change located in a relatively conserved region of said GP that decreases in vitro cytotoxicity and retains immunogenicity when compared to in vitro cytotoxicity and immunogenicity of a wild type filovirus GP, and related modified filovirus GPs, plasmid DNAs, recombinant viruses, adenoviruses, pharmaceutical compositions, vaccine compositions, antibodies that are specifically reactive with the modified filovirus GPs, and related methods of making and using the same.
    Type: Application
    Filed: September 27, 2005
    Publication date: September 17, 2009
    Inventors: Nancy Sullivan, Bimal Chakrabarti, Zhi-Yong Yang
  • Moveable counterbalanced stand alone flag pole
    Publication number: 20080098951
    Abstract: A moveable counterbalanced stand alone flag pole providing transportability and an increase of flag display locations includes a counterbalanced pole assembly having a lower portion, a mid-portion and an upper portion, such that a flag attached to the upper portion can freely wave, a ground tip on the end of the lower portion allowing the lower portion to be removably secured, and a washer in which the lower portion of the pole assembly fits whereby the pole assembly can rotate while the ground tip remains stationary.
    Type: Application
    Filed: October 25, 2006
    Publication date: May 1, 2008
    Inventor: Nancy Sullivan