Patents by Inventor Nandini Krishnamurthy

Nandini Krishnamurthy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • EXPRESSION MODULATING ELEMENTS AND USE THEREOF
    Publication number: 20240110197
    Abstract: The disclosure relates to gene expression modulation elements from plants and their use in modulating the expression of one or more heterologous nucleic acid fragments in plants. The disclosure further discloses compositions, polynucleotide constructs, transformed host cells, plants and seeds containing the expression modulating elements, and methods for preparing and using the same.
    Type: Application
    Filed: July 17, 2023
    Publication date: April 4, 2024
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: SHANE E ABBITT, MARY J FRANK, THOMAS W GREENE, NANDINI KRISHNAMURTHY, ANDREW RUPIPER
  • Expression modulating elements and use thereof
    Patent number: 11814637
    Abstract: The disclosure relates to gene expression modulation elements from plants and their use in modulating the expression of one or more heterologous nucleic acid fragments in plants. The disclosure further discloses compositions, polynucleotide constructs, transformed host cells, plants and seeds containing the expression modulating elements, and methods for preparing and using the same.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: November 14, 2023
    Inventors: Shane E Abbitt, Mary J Frank, Thomas W Greene, Nandini Krishnamurthy, Andrew Rupiper
  • Rationally-designed mutations to the thrA gene for enhanced lysine production in
    Patent number: 11787841
    Abstract: The present disclosure relates to various different types of mutations in the thrA gene in E. coli leading to enhanced lysine production for, e.g., supplements and nutraceuticals.
    Type: Grant
    Filed: May 12, 2021
    Date of Patent: October 17, 2023
    Assignee: Inscripta, Inc.
    Inventors: Eric Abbate, Katherine Krouse, Richard Fox, Daniel Held, Michael Clay, Nandini Krishnamurthy
  • MULTIPLE DISEASE RESISTANCE GENES AND GENOMIC STACKS THEREOF
    Publication number: 20230295650
    Abstract: The field is molecular biology, and more specifically, methods for chromosomal engineering of multiple native genes, such as disease resistance genes in a genomic locus using site-specific editing to produce plants. Also described herein are methods of generating heterologous genomic locus in a plant that comprises a plurality of intraspecies polynucleotide sequences.
    Type: Application
    Filed: August 17, 2021
    Publication date: September 21, 2023
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: MARY J. FRANK, HUIRONG GAO, JEFFREY HABBEN, SABRINA HUMBERT, NANDINI KRISHNAMURTHY, MICHAEL LASSNER, BAILIN LI, ROBERT B. MEELEY, LEANDRO DANIEL PERUGINI, GIRMA TABOR, PETRA J. WOLTERS
  • NOVEL PLANT TERMINATOR SEQUENCES
    Publication number: 20220119831
    Abstract: This invention relates to gene expression regulatory sequences, specifically transcription terminator sequences. Plant transcription terminator sequences are described herein. Methods for identifying novel plant transcription terminator sequences that can terminate transcription in one orientation or in a bidirectional manner and methods of using these terminator sequences to generate transgenic plants are described herein.
    Type: Application
    Filed: January 4, 2022
    Publication date: April 21, 2022
    Applicant: E.I. DU PONT DE NEMOURS AND COMPANY
    Inventors: PRIYANKA BHYRI, NANDINI KRISHNAMURTHY, ESWAR NARAYANAN, AJIT NOTT, RINKU RANJAN SARANGI
  • MULTIPLE DISEASE RESISTANCE GENES AND GENOMIC STACKS THEREOF
    Publication number: 20220056470
    Abstract: The field is molecular biology, and more specifically, methods for chromosomal engineering of multiple native genes, such as disease resistance genes in a genomic locus using site-specific editing to produce plants. Also described herein are methods of generating heterologous genomic locus in a plant that comprises a plurality of intraspecies polynucleotide sequences.
    Type: Application
    Filed: August 17, 2021
    Publication date: February 24, 2022
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: MARY J FRANK, HUIRONG GAO, JEFFREY HABBEN, SABRINA HUMBERT, NANDINI KRISHNAMURTHY, MICHAEL LASSNER, BAILIN LI, ROBERT B MEELEY, LEANDRO DANIEL PERUGINI, GIRMA M TABOR, PETRA J WOLTERS
  • Plant terminator sequences
    Patent number: 11248233
    Abstract: This invention relates to gene expression regulatory sequences, specifically transcription terminator sequences. Plant transcription terminator sequences are described herein. Methods for identifying novel plant transcription terminator sequences that can terminate transcription in one orientation or in a bidirectional manner and methods of using these terminator sequences to generate transgenic plants are described herein.
    Type: Grant
    Filed: July 11, 2018
    Date of Patent: February 15, 2022
    Inventors: Priyanka Bhyri, Nandini Krishnamurthy, Eswar Narayanan, Ajit Nott, Rinku Ranjan Sarangi
  • NUCLEIC ACID-GUIDED NUCLEASE OF NICKASE FUSION EDITING OF METHYLATED NUCLEOTIDES
    Publication number: 20220002725
    Abstract: The present disclosure relates to compositions, methods, modules and automated, integrated instrumentation to enable nucleic acid-guided nuclease or nickase fusion editing in cells and correlating the edits to the resulting cellular nucleic acid profile. In some embodiments, methylated bases in a repair template are substituted for unmethylated bases in the cellular target genome and in some embodiments, unmethylated bases are substituted for methylated bases in the cellular target genome.
    Type: Application
    Filed: June 30, 2021
    Publication date: January 6, 2022
    Inventors: Stephen Tanner, Michael Graige, Nandini Krishnamurthy, Craig Struble
  • NUCLEIC ACID WATERMARKS TO ASSESS AND IMPROVE NUCLEIC ACID-GUIDED NUCLEASE OR NICKASE FUSION EDITING
    Publication number: 20220002755
    Abstract: The present disclosure relates to compositions, methods, modules and automated integrated instrumentation to make auxiliary or ancillary edits—in addition to intended edits and immunizing edits—in cellular genomic nucleic acids in order to assess and improve nucleic acid-guided nuclease or nickase fusion editing.
    Type: Application
    Filed: June 30, 2021
    Publication date: January 6, 2022
    Inventors: Stephen Tanner, Michael Graige, Craig Struble, Nandini Krishnamurthy, Andrea Halweg-Edwards, Bryan Leland, Simon Cawley, Joshua Shorenstein, Timothy Shaver
  • RATIONALLY-DESIGNED MUTATIONS TO THE THRA GENE FOR ENHANCED LYSINE PRODUCTION IN E. COLI
    Publication number: 20210363481
    Abstract: The present disclosure relates to various different types of mutations in the thrA gene in E. coli leading to enhanced lysine production for, e.g., supplements and nutraceuticals.
    Type: Application
    Filed: May 12, 2021
    Publication date: November 25, 2021
    Inventors: Eric Abbate, Katherine Krouse, Richard Fox, Daniel Held, Michael Clay, Nandini Krishnamurthy
  • EXPRESSION MODULATING ELEMENTS AND USE THEREOF
    Publication number: 20210324401
    Abstract: The disclosure relates to gene expression modulation elements from plants and their use in modulating the expression of one or more heterologous nucleic acid fragments in plants. The disclosure further discloses compositions, polynucleotide constructs, transformed host cells, plants and seeds containing the expression modulating elements, and methods for preparing and using the same.
    Type: Application
    Filed: March 30, 2018
    Publication date: October 21, 2021
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: SHANE E ABBITT, MARY J FRANK, THOMAS W GREENE, NANDINI KRISHNAMURTHY, ANDREW RUPIPER
  • GENOME-WIDE RATIONALLY-DESIGNED MUTATIONS LEADING TO ENHANCED LYSINE PRODUCTION IN E. COLI
    Publication number: 20210317402
    Abstract: The present disclosure relates to various different types of variants in E. coli coding and noncoding regions leading to enhanced lysine production for, e.g., supplements and nutraceuticals.
    Type: Application
    Filed: June 23, 2021
    Publication date: October 14, 2021
    Inventors: Eric Abbate, Katherine Krouse, Nandini Krishnamurthy, Richard Fox, Daniel Held, Michael Clay, Krishna Yerramsetty
  • Genome-wide rationally-designed mutations leading to enhanced lysine production in
    Patent number: 11078458
    Abstract: The present disclosure relates to various different types of variants in E. coli coding and noncoding regions leading to enhanced lysine production for, e.g., supplements and nutraceuticals.
    Type: Grant
    Filed: January 26, 2021
    Date of Patent: August 3, 2021
    Assignee: Inscripta, Inc.
    Inventors: Richard Fox, Daniel Held, Eric Abbate, Michael Clay, Katherine Krouse, Nandini Krishnamurthy, Krishna Yerramsetty
  • GENOME-WIDE RATIONALLY-DESIGNED MUTATIONS LEADING TO ENHANCED LYSINE PRODUCTION IN E. COLI
    Publication number: 20210155894
    Abstract: The present disclosure relates to various different types of variants in E. coli coding and noncoding regions leading to enhanced lysine production for, e.g., supplements and nutraceuticals.
    Type: Application
    Filed: January 26, 2021
    Publication date: May 27, 2021
    Inventors: Richard Fox, Daniel Held, Eric Abbate, Michael Clay, Katherine Krouse, Nandini Krishnamurthy, Krishna Yerramsetty
  • Genome-wide rationally-designed mutations leading to enhanced lysine production in
    Patent number: 10920189
    Abstract: The present disclosure relates to various different types of variants in E. coli coding and noncoding regions leading to enhanced lysine production for, e.g., supplements and nutraceuticals.
    Type: Grant
    Filed: June 18, 2020
    Date of Patent: February 16, 2021
    Assignee: Inscripta, Inc.
    Inventors: Richard Fox, Daniel Held, Eric Abbate, Michael Clay, Katherine Krouse, Nandini Krishnamurthy, Krishna Yerramsetty
  • GENOME-WIDE RATIONALLY-DESIGNED MUTATIONS LEADING TO ENHANCED LYSINE PRODUCTION IN E. COLI
    Publication number: 20200399586
    Abstract: The present disclosure relates to various different types of variants in E. coli coding and noncoding regions leading to enhanced lysine production for, e.g., supplements and nutraceuticals.
    Type: Application
    Filed: June 18, 2020
    Publication date: December 24, 2020
    Inventors: Richard Fox, Daniel Held, Eric Abbate, Michael Clay, Katherine Krouse, Nandini Krishnamurthy, Krishna Yerramsetty
  • METHODS FOR IDENTIFICATION OF NOVEL GENES FOR MODULATING PLANT AGRONOMIC TRAITS
    Publication number: 20180363069
    Abstract: Methods and compositions for identifying novel genes useful for modulating desired agronomic traits in plants are presented herein. The present disclosure relates to methods for identifying line-specific and cluster-specific genes from plants that show perturbation of expression in response to perturbation of expression of a primary gene, and the perturbation of expression of the line-specific or cluster-specific gene confers alterations in agronomic characteristics upon the plant.
    Type: Application
    Filed: December 16, 2016
    Publication date: December 20, 2018
    Applicants: PIONEER HI-BRED INTERNATIONAL, INC., E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: SONAL BAKIWALA, DEBASIS DAN, KRUPA DESHMUKH, MARY J. FRANK, NANDINI KRISHNAMURTHY, BINDU ANDREUZZA, ROBERT WAYNE WILLIAMS, SANGEETA AGARWAL
  • NOVEL PLANT TERMINATOR SEQUENCES
    Publication number: 20180312857
    Abstract: This invention relates to gene expression regulatory sequences, specifically transcription terminator sequences. Plant transcription terminator sequences are described herein. Methods for identifying novel plant transcription terminator sequences that can terminate transcription in one orientation or in a bidirectional manner and methods of using these terminator sequences to generate transgenic plants are described herein.
    Type: Application
    Filed: July 11, 2018
    Publication date: November 1, 2018
    Applicant: E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: Priyanka Bhyri, Nandini Krishnamurthy, Eswar Narayanan, Ajit Nott, Rinku Ranjan Sarangi
  • Plant terminator sequences
    Patent number: 10059953
    Abstract: This invention relates to gene expression regulatory sequences, specifically transcription terminator sequences. Plant transcription terminator sequences are described herein. Methods for identifying novel plant transcription terminator sequences that can terminate transcription in one orientation or in a bidirectional manner and methods of using these terminator sequences to generate transgenic plants are described herein.
    Type: Grant
    Filed: July 13, 2012
    Date of Patent: August 28, 2018
    Assignee: E I DU PONT DE NEMOURS AND COMPANY
    Inventors: Priyanka Bhyri, Nandini Krishnamurthy, Eswar Narayanan, Ajit Nott, Rinku Ranjan Sarangi
  • NOVEL PLANT TERMINATOR SEQUENCES
    Publication number: 20140130205
    Abstract: This invention relates to gene expression regulatory sequences, specifically transcription terminator sequences. Plant transcription terminator sequences are described herein. Methods for identifying novel plant transcription terminator sequences that can terminate transcription in one orientation or in a bidirectional manner and methods of using these terminator sequences to generate transgenic plants are described herein.
    Type: Application
    Filed: July 13, 2012
    Publication date: May 8, 2014
    Applicant: E I DU PONT DE NEMOURS AND COMPANY
    Inventors: Priyanka Bhyri, Nandini Krishnamurthy, Eswar Narayanan, Ajit Nott, Rinku Ranjan Sarangi