Patents by Inventor Nandini Nagraj
Nandini Nagraj has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10989709Abstract: A method of recovering a target from a sample is provided. The method of recovering the target follows different steps. The steps include providing a binding element, wherein the binding elements are immobilized on a solid support, adding the sample comprising the target to the binding element to form a binding element-target complex; washing the binding element-target complex; and eluting the target from the binding element-target complex. The system for reversible detection of target in a range from 2 to 1,000,000 bind/release cycles is also provided.Type: GrantFiled: March 22, 2017Date of Patent: April 27, 2021Assignee: CYTIVA SWEDEN ABInventors: Radislav Alexandrovich Potyrailo, Andrew David Pris, Nandini Nagraj, Anthony John Murray
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Patent number: 10359419Abstract: A method of recovering a target from a sample is provided. The method comprises the adding a substrate coupled binding element to the sample comprising the target to form a substrate coupled binding element-target complex; precipitating the complex by changing one or more environmental conditions of the substrate and recovering the target and the substrate coupled binding-element under mild conditions.Type: GrantFiled: October 2, 2013Date of Patent: July 23, 2019Assignee: General Electric CompanyInventors: Anthony John Murray, Radislav Alexandrovich Potyrailo, Andrew David Pris, Nandini Nagraj
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Patent number: 10244778Abstract: A method for monitoring cooking in an oven appliance includes drawing cooking vapors or gases from a cooking chamber to a fluid analysis assembly of the oven appliance during a gas or vapor analysis cooking cycle, determining a cooking status of the food item within the cooking chamber with the controller of the oven appliance based upon a response pattern of a plurality of fluid sensors of the fluid analysis assembly to the cooking vapors or gases during the gas or vapor analysis cooking cycle, and activating an alert with the controller of the oven appliance when the cooking status of the food item within the cooking chamber is a particular cooking status.Type: GrantFiled: November 5, 2015Date of Patent: April 2, 2019Assignee: Haier US Appliance Solutions, Inc.Inventors: James Lee Armstrong, Stanton Earl Weaver, Jr., Sabrina Marie Hannah, Nandini Nagraj, Manuel Alfredo Palacios
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Patent number: 10001415Abstract: The subject matter of the present disclosure generally relates to a sensor assembly having a first component configured to melt when a temperature of the sensor assembly reaches a first value below a minimum value of a predetermined temperature range, a second component configured to melt when the temperature of the sensor assembly reaches a second value above a maximum value of the predetermined temperature range, and a third component configured to monitor a volume of fluid disposed in a vessel when the temperature of the sensor assembly is within the predetermined temperature range.Type: GrantFiled: August 11, 2015Date of Patent: June 19, 2018Assignee: General Electric CompanyInventors: Nandini Nagraj, Timothy Mark Sivavec, Yongjae Lee, Daniel Paik
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Patent number: 9828599Abstract: Methods for selecting a binding-element are provided. The method comprised of different steps. A first mixture is formed using at least one target molecule and a plurality of oligomers, followed by incubating the first mixture to form a second mixture comprising at least one target-bound oligomer and at least one target-unbound oligomer. Then a first accelerator is added to cleave the target-unbound oligomer and the target-bound oligomer is separated from the target molecule. This is followed by addition of a second accelerator for ligation, and a third accelerator for amplification followed by sequencing and post sequence analysis to select the binding-element.Type: GrantFiled: September 18, 2013Date of Patent: November 28, 2017Assignee: General Electric CompanyInventors: Nandini Nagraj, Radislav Alexandrovich Potyrailo, Andrew David Pris, John Richard Nelson
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Publication number: 20170267716Abstract: Provided herein are aptamer-polymer conjugates which are responsive to environmental stimuli and are useful in selective purification of untagged target polypeptides.Type: ApplicationFiled: March 16, 2016Publication date: September 21, 2017Inventors: Anthony John Murray, Andrew David Pris, Erik Leeming Kvam, Nandini Nagraj, Eugene Pauling Boden, Ernest William Kovacs, Louisa Ruth Carr, Rui Chen, Tiberiu Mircea Siclovan, Kelly Scott Chichak
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Publication number: 20170191992Abstract: A method of recovering a target from a sample is provided. The method of recovering the target follows different steps. The steps include providing a binding element, wherein the binding elements are immobilized on a solid support, adding the sample comprising the target to the binding element to form a binding element-target complex; washing the binding element-target complex; and eluting the target from the binding element-target complex. The system for reversible detection of target in a range from 2 to 1,000,000 bind/release cycles is also provided.Type: ApplicationFiled: March 22, 2017Publication date: July 6, 2017Inventors: Radislav Alexandrovich Potyrailo, Andrew David Pris, Nandini Nagraj, Anthony John Murray
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Patent number: 9678030Abstract: A sensor for detecting gaseous agents has a transducer, which includes an electrical resonant circuit that forms an antenna. The sensor further includes a sensing material that is disposed on at least a portion of the transducer. The sensing material is configured to simultaneously exhibit a capacitance response and a resistance response in the presence of a gaseous agent. The sensor may be reversible, battery free, and may require no electrical contact with a sensor reader.Type: GrantFiled: December 30, 2014Date of Patent: June 13, 2017Assignee: General Electricity CompanyInventors: Radislav Alexandrovich Potyrailo, Zhexiong Tang, Brandon Bartling, Nandini Nagraj, Vadim Bromberg
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Publication number: 20170130967Abstract: The present subject matter provides an oven appliance with a fluid analysis assembly fluidly mounted to a duct. The fluid analysis assembly includes a casing and a sensor array. A fluid inlet of the casing extends between the duct and a dilution chamber of the casing. An ambient inlet of the casing is contiguous with ambient air about the casing and the dilution chamber. The sensor array includes a plurality of fluid sensors positioned at the dilution chamber of the casing.Type: ApplicationFiled: November 5, 2015Publication date: May 11, 2017Inventors: Stanton Earl Weaver, JR., Gary Dwayne Mandrusiak, Nandini Nagraj
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Publication number: 20170130968Abstract: A method for monitoring cooking in an oven appliance includes drawing cooking vapors or gases from a cooking chamber to a fluid analysis assembly and exposing a plurality of fluid sensors of the fluid analysis assembly to the cooking vapors or gases. The method also includes establishing a response pattern of the plurality of fluid sensors with a machine or statistical learning model(s) and determining a cooking status of the food item within the cooking chamber based upon the response pattern of the plurality of fluid sensors.Type: ApplicationFiled: November 10, 2015Publication date: May 11, 2017Inventors: Nandini Nagraj, Stanton Earl Weaver, JR., Zhexiong Tang, Manuel Alfredo Palacios, Igor Tokarev, Matthew Vaughan Schulmerich
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Publication number: 20170127700Abstract: A method for monitoring cooking in an oven appliance includes drawing cooking vapors or gases from a cooking chamber to a fluid analysis assembly of the oven appliance during a gas or vapor analysis cooking cycle, determining a cooking status of the food item within the cooking chamber with the controller of the oven appliance based upon a response pattern of a plurality of fluid sensors of the fluid analysis assembly to the cooking vapors or gases during the gas or vapor analysis cooking cycle, and activating an alert with the controller of the oven appliance when the cooking status of the food item within the cooking chamber is a particular cooking status.Type: ApplicationFiled: November 5, 2015Publication date: May 11, 2017Inventors: James Lee Armstrong, Stanton Earl Weaver, JR., Sabrina Marie Hannah, Nandini Nagraj, Manuel Alfredo Palacios
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Patent number: 9638653Abstract: Methods and sensors for selective fluid sensing are provided. Each sensor includes a resonant inductor-capacitor-resistor (LCR) sensor that is coated with a sensing material. In order to collect data, an impedance spectrum is acquired over a relatively narrow frequency range, such as the resonant frequency range of the LCR circuit. A multivariate signature may be calculated from the acquired spectrum to discern the presence of certain fluids and/or fluid mixtures. The presence of fluids is detected by measuring the changes in dielectric, dimensional, resistance, charge transfer, and other changes in the properties of the materials employed by observing the changes in the resonant electronic properties of the circuit. By using a mathematical procedure, such as principal components analysis (PCA) and others, multiple fluids and mixtures can be detected in the presence of one another, even in a high humidity environment or an environment wherein one or more fluids has a substantially higher concentration (e.g.Type: GrantFiled: May 12, 2015Date of Patent: May 2, 2017Assignee: General Electricity CompanyInventors: Radislav Alexandrovich Potyrailo, Cheryl Margaret Surman, Andrew Arthur Paul Burns, Nandini Nagraj
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Publication number: 20170043095Abstract: The subject matter of the present disclosure generally relates to a sensor assembly having a first component configured to melt when a temperature of the sensor assembly reaches a first value below a minimum value of a predetermined temperature range, a second component configured to melt when the temperature of the sensor assembly reaches a second value above a maximum value of the predetermined temperature range, and a third component configured to monitor a volume of fluid disposed in a vessel when the temperature of the sensor assembly is within the predetermined temperature range.Type: ApplicationFiled: August 11, 2015Publication date: February 16, 2017Inventors: Nandini Nagraj, Timothy Mark Sivavec, Yongjae Lee, Daniel Paik
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Patent number: 9494541Abstract: Methods and sensors for selective fluid sensing are provided. A gas dosimeter includes a housing configured with an opening to admit an analyte. The gas dosimeter also includes a multivariate sensor disposed in the housing. The sensor is configured to determine a concentration of the analyte over time. In addition, the multivariate sensor includes an irreversible sensing material. Electrical properties of the irreversible sensing material are configured to change irreversibly upon exposure to the analyte.Type: GrantFiled: July 5, 2012Date of Patent: November 15, 2016Assignee: General Electricity CompanyInventors: Radislav Alexandrovich Potyrailo, Hubert Tunchiao Lam, Zhexiong Tang, Nandini Nagraj
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Publication number: 20160223484Abstract: Methods and sensors for selective fluid sensing are provided. Each sensor includes a resonant inductor-capacitor-resistor (LCR) sensor that is coated with a sensing material. In order to collect data, an impedance spectrum is acquired over a relatively narrow frequency range, such as the resonant frequency range of the LCR circuit. A multivariate signature may be calculated from the acquired spectrum to discern the presence of certain fluids and/or fluid mixtures. The presence of fluids is detected by measuring the changes in dielectric, dimensional, resistance, charge transfer, and other changes in the properties of the materials employed by observing the changes in the resonant electronic properties of the circuit. By using a mathematical procedure, such as principal components analysis (PCA) and others, multiple fluids and mixtures can be detected in the presence of one another, even in a high humidity environment or an environment wherein one or more fluids has a substantially higher concentration (e.g.Type: ApplicationFiled: May 12, 2015Publication date: August 4, 2016Inventors: Radislav Alexandrovich Potyrailo, Cheryl Margaret Surman, Andrew Arthur Paul Burns, Nandini Nagraj
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Publication number: 20160187280Abstract: A sensor for detecting gaseous agents has a transducer, which includes an electrical resonant circuit that forms an antenna. The sensor further includes a sensing material that is disposed on at least a portion of the transducer. The sensing material is configured to simultaneously exhibit a capacitance response and a resistance response in the presence of a gaseous agent. The sensor may be reversible, battery free, and may require no electrical contact with a sensor reader.Type: ApplicationFiled: December 30, 2014Publication date: June 30, 2016Inventors: Radislav Alexandrovich Potyralio, Zhexiong Tang, Brandon Bartling, Nandini Nagraj, Vadim Bromberg
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Publication number: 20160033140Abstract: An oven appliance with a sensor for sensing gases in the cooking chamber is provided. One or more features and methods are provided for detecting the gas levels in the cooking chamber to determine if the cooking chamber is clean or unclean. Features for initiating and terminating an oven cleaning cycle are also provided.Type: ApplicationFiled: July 30, 2014Publication date: February 4, 2016Inventors: Stanton Earl Weaver, JR., Nandini Nagraj, William Guy Morris, Todd-Michael Striker, Zhexiong Tang, Manuel Alfredo Palacios
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Patent number: 9037418Abstract: Methods and sensors for selective fluid sensing are provided. Each sensor includes a resonant inductor-capacitor-resistor (LCR) sensor that is coated with a sensing material. In order to collect data, an impedance spectrum is acquired over a relatively narrow frequency range, such as the resonant frequency range of the LCR circuit. A multivariate signature may be calculated from the acquired spectrum to discern the presence of certain fluids and/or fluid mixtures. The presence of fluids is detected by measuring the changes in dielectric, dimensional, resistance, charge transfer, and other changes in the properties of the materials employed by observing the changes in the resonant electronic properties of the circuit. By using a mathematical procedure, such as principal components analysis (PCA) and others, multiple fluids and mixtures can be detected in the presence of one another, even in a high humidity environment or an environment wherein one or more fluids has a substantially higher concentration (e.g.Type: GrantFiled: September 19, 2013Date of Patent: May 19, 2015Assignee: General Electric CompanyInventors: Radislav Alexandrovich Potyrailo, Cheryl Margaret Surman, Andrew Arthur Paul Burns, Nandini Nagraj
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Publication number: 20150093820Abstract: A method of recovering a target from a sample is provided. The method comprises the adding a substrate coupled binding element to the sample comprising the target to form a substrate coupled binding element-target complex; precipitating the complex by changing one or more environmental conditions of the substrate and recovering the target and the substrate coupled binding-element under mild conditions.Type: ApplicationFiled: October 2, 2013Publication date: April 2, 2015Applicant: General Electric CompanyInventors: Anthony John Murray, Radislav Alexandrovich Potyrailo, Andrew David Pris, Nandini Nagraj
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Publication number: 20150093839Abstract: A method of recovering a target from a sample is provided. The method of recovering the target follows different steps. The steps include providing a binding element, wherein the binding elements are immobilized on a solid support, adding the sample comprising the target to the binding element to form a binding element-target complex; washing the binding element-target complex; and eluting the target from the binding element-target complex. The system for reversible detection of target in a range from 2 to 1,000,000 bind/release cycles is also provided.Type: ApplicationFiled: October 2, 2013Publication date: April 2, 2015Applicant: General Electric CompanyInventors: Radislav Alexandrovich Potyrailo, Andrew David Pris, Nandini Nagraj, Anthony John Murray