Abstract: The present invention relates to implantable medical devices, such as stents, that comprise a composition for controlled delivery of flavonoids or a derivative thereof. The flavonoids are aimed at preventing or reducing secondary complications which can occur following implantation of the device such as e.g. occlusive and catastrophic vascular phenomena. The invention further relates to the inclusion of additional therapeutic agents in the system that may have antiproliferative, antimitotic, antimicrobial, anticoagulant, fibrinolytic, anti-inflammatory, immunosurpressive, and anti-angiogenic activities. The composition comprising the flavanoids and optional further therapeutic agents may be used in methods for treating or preventing narrowing or obstruction of the body passageway. In particular the devices and compositions of the invention are useful in methods for treating or preventing restenosis, e.g.

Abstract: A composition comprising at least one polymer covalently bonded to heparin, and at least one pharmaceutically active agent other than heparin dispersed within the at least one polymer.

Abstract: An implantable medical device, comprising a polymer coated on at least a portion of the medical device, and a pharmaceutically active agent covalently bonded to the polymer.

Abstract: A composition comprising a first polymer having pores, nanoparticles dispersed within the pores of the first polymer, the nanoparticles comprising a second polymer and at least one pharmaceutically active agent dispersed in the second polymer, and heparin covalently bonded to at least one of the first and second polymer.

Abstract: An implantable medical device comprising an expandable balloon having an outer surface, a polymer coated on at least a portion of the outer surface of the balloon, and a pharmaceutically active agent dispersed within the polymer.

Abstract: A pharmaceutical or medicinal preparation which comprises a mixture of the following five herbs: Boerhavia Diffusa, Picorrhiza Kurroa, Tephrosia Purpurea, Curcuma Longa and Trigonella Foenum-Graecum, or a mixture of the active ingredients that have been extracted from those herbs. The herbal formulation of the invention is effective for the treatment of hepatic and splenic disorders, thalassemias, Wilson's Disease, hematological malignancies, and as an adjuvant to cancer therapy.

Abstract: A pharmaceutical or medicinal preparation comprising a mixture of arsenic trioxide (As2O3) and the herbs Aloe Vera (Aloe Barbedensis), Withania Somnifera, Glycine Max, Rubia Cordifolia and Acacia Catechu, or a mixture of the active ingredients that have been extracted from those herbs. The herbo-mineral formulation of the invention is effective for the treatment of cancer, in particular refractory leukemias, lymphomas, myelodysplastic syndrome and aplastic anemias.