Abstract: The present invention relates to the viscosity reduction and stability enhancement of biotherapeutics in biomanufacturing and formulation. The method of viscosity reduction and stability enhancement comprises combining a biotherapeutic with a performance-enhancing excipient chosen from bis acetyl arginine, bis acetyl lysine, bis acetyl histidine, bis acetyl serine, bis acetyl proline, bis acetyl tryptophan, propionyl arginine, propionyl lysine, propionyl histidine, propionyl serine, propionyl proline, propionyl tryptophan, and mixtures thereof.

Abstract: The present invention provides a membrane rupture solution comprising: one or more purified non-ionic detergents, wherein at least one of the detergents has a surface activity property that is suitable for viral vector/protein stabilization against shear stress, and, optionally, a scavenger.

Abstract: Separation of a variety of analytes that are polar, nonpolar and ionic using functionalized polymeric media is disclosed. Preformed rigid particles of highly crosslinked homopolymer of polyvinylidene compounds are functionalized using the residual vinyl groups onto which monovinyl compounds are covalently bonded through polymerization. The functionalization imparts desirable surface properties for separation applications such as liquid chromatography and solid phase extraction.