Patents by Inventor Nanette H. Bishopric

Nanette H. Bishopric has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tissue specific hypoxia regulated constructs
    Patent number: 6218179
    Abstract: Methods and compositions relating to chimeric genes containing (i) a tissue-specific promoter and (ii) a hypoxia response enhancer element, both of which are operably linked to a selected gene, such as a reporter gene, therapeutic gene (e.g., bcl-2, NOS, catalase and SOD), or deleterious gene are disclosed. Expression of the selected gene is enhanced in the target tissue under hypoxia conditions, such as conditions encountered during episodes of ischemia and reperfusion. The methods and compositions may be used as therapeutics and/or diagnostics.
    Type: Grant
    Filed: June 23, 1997
    Date of Patent: April 17, 2001
    Assignee: SRI International
    Inventors: Keith A. Webster, Nanette H. Bishopric, Brian Murphy, Keith R. Laderoute, Christopher J. Green
  • Matrix substrate for a viable body tissue-derived prosthesis and method for making the same
    Patent number: 5855620
    Abstract: Disclosed is a process for treating body tissues such as vascular structures to remove barriers to recellularization before and after implantation in a human host. The body tissue, for example a heart valve, is subjected to a hypotonic/hypertonic treatment, then treated with enzymes to provide a collagen- and elastin-containing matrix suitable for recellularization.
    Type: Grant
    Filed: October 30, 1996
    Date of Patent: January 5, 1999
    Assignee: St. Jude Medical, Inc.
    Inventors: Nanette H. Bishopric, Linda Dousman, Yung-mae M. Yao
  • Tissue specific hypoxia regulated therapeutic constructs
    Patent number: 5834306
    Abstract: Methods and compositions relating to chimeric genes containing (i) a tissue-specific promoter and (ii) a hypoxia response enhancer element, both of which are operably linked to a selected gene, such as a reporter gene, therapeutic gene (e.g., bcl-2, NOS, catalase and SOD), or deleterious gene are disclosed. Expression of the selected gene is enhanced in the target tissue under hypoxic conditions, such as conditions encountered during episodes of ischemia and reperfusion. The methods and compositions may be used as therapeutics and/or diagnostics.
    Type: Grant
    Filed: December 23, 1994
    Date of Patent: November 10, 1998
    Assignee: SRI International
    Inventors: Keith A. Webster, Nanette H. Bishopric