Abstract: According to various embodiments, a light microscope is provided.

Abstract: An optical measurement method for high-speed acquisition of integral transformed time domain optical signals is presented. A circuit network is used to generate a modulation signal and a reference signal from a broadband signal such as a pseudo random bit sequence. The integral transformed measurements are obtained by cross correlating the time dependent response to the modulated illumination with the reference signal.

Abstract: An optical measurement method for high-speed acquisition of integral transformed time domain optical signals is presented. A circuit network is used to generate a modulation signal and a reference signal from a broadband signal such as a pseudo random bit sequence. The integral transformed measurements are obtained by cross correlating the time dependent response to the modulated illumination with the reference signal.

Abstract: A fluorescence focal modulation microscopy system and method is disclosed for high resolution molecular imaging of thick biological tissues with single photon excited fluorescence. Optical sectioning and diffraction limited spatial resolution are retained for imaging inside a multiple-scattering medium by the use of focal modulation, a technique for suppressing the background fluorescence signal excited by the scattered light. The focal modulation microscopy system has a spatial phase modulator inserted in the excitation light path, which varies the spatial distribution of coherent excitation light around the focal volume periodically at a preset frequency. A fluorescence focal modulation image is formed on a display with the demodulated fluorescence, while a confocal image is available simultaneously.

Abstract: A high speed, high duty cycle, linear, optical scanning device suitable for optical coherence tomography, optical coherence microscopy and confocal microscopy is presented. For the microscopy applications stable, periodic scanning is achieved by using a rotary mirror array, having a rotational symmetry and mirrors tilted at a small angle with respect to the rotational plane. The rotary mirror array is rotated at a constant speed. For the tomography application periodic modulation of the optical path-length of the reference beam is controlled by the rotation of the rotary mirror array.

Abstract: A high speed, high duty cycle, linear, optical scanning device suitable for optical coherence tomography, optical coherence microscopy and confocal microscopy is presented. For the microscopy applications stable, periodic scanning is achieved by using a rotary mirror array, having a rotational symmetry and mirrors tilted at a small angle with respect to the rotational plane. The rotary mirror array is rotated at a constant speed. For the tomography application periodic modulation of the optical path-length of the reference beam is controlled by the rotation of the rotary mirror array.