Patents by Inventor Nani Van Gerven

Nani Van Gerven has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220162264
    Abstract: The present invention relates to novel protein pores and their uses in analyte detection and characterisation. The invention particularly relates to an isolated pore complex formed by a CsgG-like pore and a modified CsgF peptide, or a homologue or mutant thereof, thereby incorporating an additional channel constriction or reader head in the nanopore. The invention further relates to a transmembrane pore complex and methods for production of the pore complex and for use in molecular sensing and nucleic acid sequencing applications.
    Type: Application
    Filed: March 18, 2021
    Publication date: May 26, 2022
    Applicants: Oxford Nanopore Technologies Limited, VIB VZW, Vrije Universiteit Brussel
    Inventors: Han Remaut, Sander Van Der Verren, Nani Van Gerven, Lakmal Jayasinghe, Elizabeth Jayne Wallace, Pratik Raj Singh, Richard George Hambley, Michael Jordan, John Joseph Kilgour
  • Publication number: 20220056517
    Abstract: A system for characterising a target polynucleotide, the system comprising a membrane and a pore complex; wherein the pore complex comprises: (i) a nanopore located in the membrane, and (ii) an auxiliary protein or peptide attached to the nanopore; wherein the nanopore and the auxiliary protein or peptide together form a continuous channel across the membrane, the channel comprising a first constriction region and a second constriction region; wherein the first constriction region is formed by a portion of the nanopore, and wherein the second constriction region is formed by at least a portion of the auxiliary protein or peptide.
    Type: Application
    Filed: November 7, 2019
    Publication date: February 24, 2022
    Applicants: Oxford Nanopore Technologies Limited, VIB VZW, Vrije Universiteit Brussel
    Inventors: Han Remaut, Sander Van Der Verren, Nani Van Gerven, Lakmal Nishantha Jayasinghe, Elizabeth Jayne Wallace, Pratik Raj Singh, Richard George Hambley, Michael Robert Jordan, John Joseph Kilgour, Andrew John Heron
  • Publication number: 20220024985
    Abstract: The present invention relates to novel protein pores and their uses in analyte detection and characterisation. The invention particularly relates to an isolated pore complex formed by a CsgG-like pore and a modified CsgF peptide, or a homologue or mutant thereof, thereby incorporating an additional channel constriction or reader head in the nanopore. The invention further relates to a transmembrane pore complex and methods for production of the pore complex and for use in molecular sensing and nucleic acid sequencing applications.
    Type: Application
    Filed: July 2, 2018
    Publication date: January 27, 2022
    Applicants: Oxford Nanopore Technologies Limited, VIB VZW, Vrije Universiteit Brussel
    Inventors: Han Remaut, Sander Egbert Van Der Verren, Nani Van Gerven, Lakmal Nishantha Jayasinghe, Elizabeth Jayne Wallace, Pratik Raj Singh, Richard George Hambley, Michael Robert Jordan, John Joseph Kilgour
  • Publication number: 20210284696
    Abstract: The present invention relates to novel protein pores and their uses in analyte detection and characterisation. The invention particularly relates to an isolated pore complex formed by a CsgG-like pore and a modified CsgF peptide, or a homologue or mutant thereof, thereby incorporating an additional channel constriction or reader head in the nanopore. The invention further relates to a transmembrane pore complex and methods for production of the pore complex and for use in molecular sensing and nucleic acid sequencing applications.
    Type: Application
    Filed: March 18, 2021
    Publication date: September 16, 2021
    Applicants: Oxford Nanopore Technologies Limited, VIB VZW, Vrije Universiteit Brussel
    Inventors: Han Remaut, Sander Van Der Verren, Nani Van Gerven, Lakmal Jayasinghe, Elizabeth Jayne Wallace, Pratik Raj Singh, Richard George Hambley, Michael Jordan, John Joseph Kilgour
  • Publication number: 20210147486
    Abstract: The present invention relates to novel protein pores and their uses in analyte detection and characterisation. The invention particularly relates to an isolated pore complex formed by a CsgG-like pore and a modified CsgF peptide, or a homologue or mutant thereof, thereby incorporating an additional channel constriction or reader head in the nanopore. The invention further relates to a transmembrane pore complex and methods for production of the pore complex and for use in molecular sensing and nucleic acid sequencing applications.
    Type: Application
    Filed: July 2, 2018
    Publication date: May 20, 2021
    Applicants: Oxford Nanopore Technologies Limited, VIB VZW, Vrije Universiteit Brussel
    Inventors: Han Remaut, Sander Egbert Van Der Verren, Nani Van Gerven, Lakmal Nishantha Jayasinghe, Elizabeth Jayne Wallace, Pratik Raj Singh, Richard George Hambley, Michael Robert Jordan, John Joseph Kilgour
  • Publication number: 20160326220
    Abstract: This disclosure relates to the display of proteins and peptides on cellular or non-biotic surfaces in the form of multivalent filamentous polymers. In particular, the disclosure provides for tools and methods for the secretion and functional display of chimeric polypeptides on the surface of cells, in particular, bacterial cells, as well as on foreign substrates, both biological and synthetic. Further envisaged are biotechnological applications using the same.
    Type: Application
    Filed: December 24, 2014
    Publication date: November 10, 2016
    Inventors: Han Remaut, Nani Van Gerven