Patents by Inventor Nanthakumar Subramaniam

Nanthakumar Subramaniam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vitamin D receptor/SMAD genomic circuit gates fibrotic response
    Patent number: 10238667
    Abstract: The present disclosure provides compositions that include a nanoparticle and a compound that increases the biological activity of the vitamin D receptor (VDR) (e.g., a VDR agonist), and methods of using such compounds to increase retention or storage of vitamin A, vitamin D, and/or lipids by a cell, such as an epithelial or stellate cell. Such methods can be used to treat or prevent fibrosis.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: March 26, 2019
    Assignees: Salk Institute for Biological Studies, The University of Sydney
    Inventors: Ning Ding, Michael Downes, Christopher Liddle, Ronald M. Evans, Nanthakumar Subramaniam
  • Use of vitamin D receptor agonists, ligands, and precursors to treat pancreatic fibrosis
    Patent number: 8318708
    Abstract: This application relates to methods of treating and ameliorating fibrosis, such as fibrosis of the pancreas. In particular, the application relates to methods of using a vitamin D receptor agonist (such as vitamin D, vitamin D analogs, vitamin D precursors, and vitamin D receptor agonists precursors) for the treatment of pancreatic fibrosis.
    Type: Grant
    Filed: May 3, 2010
    Date of Patent: November 27, 2012
    Assignees: Salk Institute for Biological Studies, University of Sydney
    Inventors: Ronald M. Evans, Michael Downes, Christopher Liddle, Nanthakumar Subramaniam, Caroline Flora Samer
  • USE OF VITAMIN D RECEPTOR AGONISTS AND PRECURSORS TO TREAT FIBROSIS
    Publication number: 20110014126
    Abstract: This application relates to methods of treating, preventing, and ameliorating fibrosis, such as fibrosis of the liver. In particular, the application relates to methods of using a vitamin D receptor agonist (such as vitamin D, vitamin D analogs, vitamin D precursors, and vitamin D receptor agonists precursors) for the treatment of liver fibrosis. Also disclosed are methods for screening for agents that treat, prevent, and ameliorate fibrosis.
    Type: Application
    Filed: May 3, 2010
    Publication date: January 20, 2011
    Inventors: Ronald M. Evans, Michael Downes, Christopher Liddle, Nanthakumar Subramaniam, Caroline Flora Samer
  • Muscle transcription factors
    Publication number: 20050032696
    Abstract: Methods are provided for regulating muscle type by regulating the function of MusTRD polypeptides. Also provided are novel isoforms of the MusTRD gene.
    Type: Application
    Filed: May 21, 2004
    Publication date: February 10, 2005
    Inventors: Edna Hardeman, Nanthakumar Subramaniam, Kim Guven, Enoch Ern Tay, Patsie Polly, Laura Issa