Patents by Inventor Nanying Bian

Nanying Bian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of reducing level of one or more impurities in a sample during protein purification
    Patent number: 11634457
    Abstract: The present invention provides novel and improved protein purification processes which incorporate certain types of carbonaceous materials and result in effective and selective removal of certain undesirable impurities without adversely affecting the yield of the desired protein product.
    Type: Grant
    Filed: March 20, 2019
    Date of Patent: April 25, 2023
    Assignee: EMD Millipore Corporation
    Inventors: Nanying Bian, Christopher Gillespie, Matthew T. Stone, Mikhail Kozlov, Jie Chen, Martin Siwak
  • CAUSTIC STABLE CHROMATOGRAPHY LIGANDS
    Publication number: 20210388036
    Abstract: The present invention relates to chromatography ligands having improved caustic stability, e.g., ligands based on immunoglobulin-binding proteins such as, Staphylococcal protein A, as well as methods of making and using such ligands.
    Type: Application
    Filed: July 29, 2021
    Publication date: December 16, 2021
    Inventors: Nanying Bian, Neil Soice, Shari Spector, Kara Levine
  • Caustic stable chromatography ligands
    Patent number: 11084851
    Abstract: The present invention relates to chromatography ligands having improved caustic stability, e.g., ligands based on immunoglobulin-binding proteins such as, Staphylococcal protein A, as well as methods of making and using such ligands.
    Type: Grant
    Filed: August 27, 2018
    Date of Patent: August 10, 2021
    Assignee: EMD MILLIPORE CORPORATION
    Inventors: Nanying Bian, Neil Soice, Shari Spector, Kara Levine
  • Methods of cleaning a protein A based affinity chromatography column
    Patent number: 11014129
    Abstract: The present invention provides methods for cleaning a Protein A chromatography column employing a media comprising a Protein A ligand derived from the C domain of Staphylococcus aureus, such that the column can be cleaned using both acidic and alkaline solutions.
    Type: Grant
    Filed: June 19, 2014
    Date of Patent: May 25, 2021
    Assignee: EMD Millipore Corporation
    Inventors: Nanying Bian, Sapna Mehtani, John Dana Hubbard
  • NOVEL AFFINITY CHROMATOGRAPHY MEDIA FOR REMOVAL OF ANTI-A AND/OR ANTI-B ANTIBODIES
    Publication number: 20210047430
    Abstract: Embodiments described herein relate to novel chromatography media for removing anti-A and/or anti-B antibodies from a sample, as well as methods of using the same. The media described herein have several advantages over previously described media including, acid and alkaline stability.
    Type: Application
    Filed: November 4, 2020
    Publication date: February 18, 2021
    Inventors: Nanying Bian, Chia-Yun Sun, Melissa Holstein, Kristen Cotoni, Matthew T. Stone, Santosh Rahane
  • Methods of evaluating quality of a chromatography media which binds anti-A or anti-B antibodies
    Patent number: 10697982
    Abstract: Embodiments described herein relate to methods of evaluating quality of a chromatography media for removal of anti-A or anti-B antibodies from a sample, where the methods employ use of purified monoclonal IgM-A and IgM-B antibodies.
    Type: Grant
    Filed: August 2, 2016
    Date of Patent: June 30, 2020
    Assignee: Merck Patent GmbH
    Inventors: Matthew T. Stone, Nanying Bian, Santosh Rahane
  • Methods of evaluating quality of media suitable for removing anti-A or anti-B antibodies
    Patent number: 10697983
    Abstract: Embodiments described herein relate to methods of evaluating quality of a chromatography media for removal of anti-A or anti-B antibodies from a sample, where the methods employ use of purified Lectins.
    Type: Grant
    Filed: August 2, 2016
    Date of Patent: June 30, 2020
    Assignee: Merck Patent GmbH
    Inventors: Santosh Rahane, Matthew Turiano, Nanying Bian, Matthew T. Stone
  • Methods of increasing protein purity using protein A based chromatography
    Patent number: 10472389
    Abstract: The present invention provides methods for increasing purity of an Fc-containing protein by removing protein aggregates during the Protein A chromatography step used during the purification of the Fc-containing protein.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: November 12, 2019
    Assignee: EMD Millipore Corporation
    Inventors: Nanying Bian, Melissa Holstein
  • METHODS OF REDUCING LEVEL OF ONE OR MORE IMPURITIES IN A SAMPLE DURING PROTEIN PURIFICATION
    Publication number: 20190218250
    Abstract: The present invention provides novel and improved protein purification processes which incorporate certain types of carbonaceous materials and result in effective and selective removal of certain undesirable impurities without adversely affecting the yield of the desired protein product.
    Type: Application
    Filed: March 20, 2019
    Publication date: July 18, 2019
    Inventors: Nanying Bian, Christopher Gillespie, Matthew T. Stone, Mikhail Kozlov, Jie Chen, Martin Siwak
  • Methods of reducing level of one or more impurities in a sample during protein purification
    Patent number: 10287314
    Abstract: The present invention provides novel and improved protein purification processes which incorporate certain types of carbonaceous materials and result in effective and selective removal of certain undesirable impurities without adversely effecting the yield of the desired protein product.
    Type: Grant
    Filed: June 23, 2015
    Date of Patent: May 14, 2019
    Assignee: EMD Millipore Corporation
    Inventors: Nanying Bian, Christopher Gillespie, Matthew T. Stone, Mikhail Kozlov, Jie Chen, Martin Siwak
  • Surface modification of porous base supports
    Patent number: 10166527
    Abstract: The present invention relates to new separation materials with improved binding capacity, its manufacturing, and application, especially for binding protein A.
    Type: Grant
    Filed: October 2, 2013
    Date of Patent: January 1, 2019
    Assignee: MERCK PATENT GMBH
    Inventors: Santosh Rahane, Nanying Bian, Daniel Scheid
  • CAUSTIC STABLE CHROMATOGRAPHY LIGANDS
    Publication number: 20180362595
    Abstract: The present invention relates to chromatography ligands having improved caustic stability, e.g., ligands based on immunoglobulin-binding proteins such as, Staphylococcal protein A, as well as methods of making and using such ligands.
    Type: Application
    Filed: August 27, 2018
    Publication date: December 20, 2018
    Inventors: Nanying Bian, Neil Soice, Shari Spector, Kara Levine
  • Caustic stable chromatography ligands
    Patent number: 10072050
    Abstract: The present invention relates to chromatography ligands having improved caustic stability, e.g., ligands based on immunoglobulin-binding proteins such as, Staphylococcal protein A, as well as methods of making and using such ligands.
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: September 11, 2018
    Assignee: EMD Millipore Corporation
    Inventors: Nanying Bian, Neil Soice, Shari Spector, Kara Levine
  • METHODS OF EVALUATING QUALITY OF MEDIA SUITABLE FOR REMOVING ANTI-A OR ANTI-B ANTIBODIES
    Publication number: 20170067915
    Abstract: Embodiments described herein relate to methods of evaluating quality of a chromatography media for removal of anti-A or anti-B antibodies from a sample, where the methods employ use of purified Lectins.
    Type: Application
    Filed: August 2, 2016
    Publication date: March 9, 2017
    Inventors: Santosh Rahane, Matthew Turiano, Nanying Bian, Matthew T. Stone
  • NOVEL AFFINITY CHROMATOGRAPHY MEDIA FOR REMOVAL OF ANTI-A AND/OR ANTI-B ANTIBODIES
    Publication number: 20170066839
    Abstract: Embodiments described herein relate to novel chromatography media for removing anti-A and/or anti-B antibodies from a sample, as well as methods of using the same. The media described herein have several advantages over previously described media including, acid and alkaline stability.
    Type: Application
    Filed: August 2, 2016
    Publication date: March 9, 2017
    Inventors: Nanying Bian, Chia-Yun Sun, Melissa Holstein, Kristen Cotoni, Matthew T. Stone, Santosh Rahane
  • METHODS OF EVALUATING QUALITY OF A CHROMATOGRAPHY MEDIA WHICH BINDS ANTI-A OR ANTI-B ANTIBODIES
    Publication number: 20170067914
    Abstract: Embodiments described herein relate to methods of evaluating quality of a chromatography media for removal of anti-A or anti-B antibodies from a sample, where the methods employ use of purified monoclonal IgM-A and IgM-B antibodies.
    Type: Application
    Filed: August 2, 2016
    Publication date: March 9, 2017
    Inventors: Matthew T. Stone, Nanying Bian, Santosh Rahane
  • Media for affinity chromatography
    Patent number: 9587009
    Abstract: The invention relates generally to solid supports for chromatography. In specific embodiments the invention provides for solid supports suitable for affinity chromatography along with methods, systems and kits which use the same.
    Type: Grant
    Filed: July 7, 2014
    Date of Patent: March 7, 2017
    Assignee: EMD Millipore Corporation
    Inventors: Nanying Bian, Senthil Ramaswamy, Neil Soice, Chen Wang, Yuan Wong
  • PROTEIN A CHROMATOGRAPHY
    Publication number: 20160193633
    Abstract: The present invention provides methods for cleaning a Protein A chromatography column employing a media comprising a Protein A ligand derived from the C domain of Staphylococcus aureus, such that the column can be cleaned using both acidic and alkaline solutions.
    Type: Application
    Filed: June 19, 2014
    Publication date: July 7, 2016
    Inventors: Nanying Bian, Sapna Mehtani, John Dana Hubbard
  • Chromatography matrices including novel protein a based ligands
    Patent number: 9376474
    Abstract: The present invention relates to chromatography matrices including ligands based on one or more domains of immunoglobulin-binding proteins such as, Staphylococcus aureus Protein A (SpA), as well as methods of using the same.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: June 28, 2016
    Assignee: EMD Millipore Corporation
    Inventors: Shari Spector, Robert Smith, Joe Orlando, Nanying Bian
  • CHROMATOGRAPHY MATRICES INCLUDING NOVEL STAPHYLOCOCCUS AUREUS PROTEIN A BASED LIGANDS
    Publication number: 20160168194
    Abstract: The present invention relates to chromatography matrices including ligands based on one or more domains of immunoglobulin-binding proteins such as, Staphylococcus aureus Protein A (SpA), as well as methods of using the same.
    Type: Application
    Filed: December 16, 2015
    Publication date: June 16, 2016
    Inventors: Shari Spector, Robert Smith, Joe Orlando, Nanying Bian