Abstract: The present disclosure relates to methods for inactivating a Zika virus which can be used in vaccines and immunogenic compositions. The present disclosure also relates to a method for determining the completeness of inactivation of an arbovirus preparation and to a method for determining the residual formaldehyde content in a pharmaceutical composition comprising an inactivated virus.

Abstract: The present disclosure relates to methods for inactivating a Zika virus which can be used in vaccines and immunogenic compositions. The present disclosure also relates to a method for determining the completeness of inactivation of an arbovirus preparation and to a method for determining the residual formaldehyde content in a pharmaceutical composition comprising an inactivated virus.

Abstract: A fuel injection device has a valve body, a drive portion, a nozzle needle, and a control valve body. The valve body defines a control chamber, a valve chamber and a low pressure communication passage. The nozzle needle is displaced due to a fuel pressure variation in the control chamber to open/close an injection port. When the control valve body sits on an upper seat surface, a low pressure communication passage is closed so that the valve chamber is fluidly disconnected from the low pressure chamber. The control valve body defines a gap restriction on the upper seat surface. A flow passage area of a sub orifice provided to the low pressure communication passage is smaller than a flow passage area of the gap restriction.

Abstract: A fuel injection device has a valve body, a drive portion, a nozzle needle, and a control valve body. The valve body defines a control chamber, a valve chamber and a low pressure communication passage. The nozzle needle is displaced due to a fuel pressure variation in the control chamber to open/close an injection port. When the control valve body sits on an upper seat surface, a low pressure communication passage is closed so that the valve chamber is fluidly disconnected from the low pressure chamber. The control valve body defines a gap restriction on the upper seat surface. A flow passage area of a sub orifice provided to the low pressure communication passage is smaller than a flow passage area of the gap restriction.

Abstract: A supply pump includes a housing, a tappet, a guide groove, and a stopper pin. The housing includes a cylindrical sliding wall. The tappet is configured to be reciprocated along the sliding wall. The guide groove is provided for one of the housing and the tappet. One end of the guide groove includes a tapered surface. The stopper pin is provided for the other one of the housing and the tappet. The stopper pin is fitted into the guide groove to stop rotation of the tappet relative to the housing. When the tappet is displaced abnormally in an upper direction, the tapered surface is pressed on an end of the stopper pin to be engaged with the stopper pin.