Patents by Inventor Nao YAMAZAKI

Nao YAMAZAKI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240302353
    Abstract: An object of the present invention is to provide a cell culture device capable of reproducing, in vitro, a growth and proliferation environment of an anaerobic bacterium in a living body; a kit for cell culture; and a cell culture method. According to the present invention, there is provided a cell culture device including a plate having a concave portion for accommodating a culture medium, a cell accommodating container having a gas permeable membrane, a first member for holding the cell accommodating container, and a second member having a structure for regulating a gas concentration in an upper space of the cell accommodating container, in which, in a case where a cell sheet is formed on an upper surface of the gas permeable membrane, a space above the gas permeable membrane is in a sealed state in which gas does not pass through.
    Type: Application
    Filed: May 17, 2024
    Publication date: September 12, 2024
    Applicant: FUJIFILM Corporation
    Inventors: Nao YAMAZAKI, Keiji SHIGESADA, Akira WAKABAYASHI, Shinji MIMA, Yuki IMAKURA
  • Publication number: 20240279613
    Abstract: An object of the present invention is to provide a method of producing an enteroendocrine cell by using an intestinal stem cell induced from a pluripotent stem cell, a method of analyzing a disease mechanism, an evaluation method for a test substance, a screening method for a therapeutic drug for a digestive system disease, an enteroendocrine cell derived from a pluripotent stem cell, a culture medium or a culture medium kit, and a kit for producing an enteroendocrine cell. According to the present invention, there is provided a method of producing an enteroendocrine cell, the method including an intestinal stem cell or an intestinal epithelial cell, which is induced from a pluripotent stem cell, by using a culture medium that substantially does not contain a ligand of an epidermal growth factor but contains a cAMP activator and a DNA methyltransferase inhibitor.
    Type: Application
    Filed: April 24, 2024
    Publication date: August 22, 2024
    Applicant: FUJIFILM Corporation
    Inventors: Nao YAMAZAKI, Shinji MIMA, Yuki IMAKURA
  • Publication number: 20230126568
    Abstract: An object of the present invention is to provide a method of producing an intestinal epithelial cell, which has a large number of cells per area and a high accuracy of kinetic prediction for a CYP3A4 substrate drug such as midazolam, by inducing the differentiation of a pluripotent stem cell, as well as the intestinal epithelial cell, a cell sheet, an evaluation method for a test substance, a screening kit for a test substance, and a cell preparation.
    Type: Application
    Filed: December 23, 2022
    Publication date: April 27, 2023
    Applicant: FUJIFILM Corporation
    Inventors: Yuki IMAKURA, Shinji MIMA, Izumi OGURA, Nao YAMAZAKI
  • Publication number: 20220267704
    Abstract: An object of the present invention is to provide a transportation instrument and a transportation method that enable transportation by using a cell culture container as it is. Further, an object of the present invention is to provide a transportation instrument and a transportation method that enable supply of oxygen required for respiration of cells. Further, an object of the present invention is to provide a transportation instrument and a transportation method that enable suppression of migration of a culture medium into and out of cells caused by the influence of an increase in internal pressure with respect to the temperature during transportation.
    Type: Application
    Filed: May 11, 2022
    Publication date: August 25, 2022
    Applicant: FUJIFILM Corporation
    Inventors: Izumi OGURA, Keiji SHIGESADA, Shinji MIMA, Yuki IMAKURA, Shun GOTO, Nao YAMAZAKI
  • Publication number: 20200362302
    Abstract: An object of the present invention is to provide a method for producing a pluripotent stem cell that can efficiently differentiate into a target differentiated cell. According to the present invention, a method for producing a cell is provided, the method including a first step of obtaining an undifferentiated cell which is obtained by introducing a reprogramming factor into a somatic cell and has a relatively low ability to differentiate into a specific differentiated cell; and a second step of treating the cell while maintaining an undifferentiated state of the cell to obtain a cell having a relatively high ability to differentiate into the specific differentiated cell.
    Type: Application
    Filed: July 31, 2020
    Publication date: November 19, 2020
    Applicant: FUJIFILM Corporation
    Inventors: Nao YAMAZAKI, Yuta MURAKAMI, Masaki HOSOYA, Taichi MURAGUCHI