Patents by Inventor Nao Yoneki

Nao Yoneki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polymer derivative of macrolide immunosuppressant
    Patent number: 10945997
    Abstract: An object of the invention is to obtain a preparation which shows enhanced effectiveness and safety compared to tacrolimus, has the concentration in blood maintained at a constant level without individual differences, whereby the control of the amount of administration depending on the blood kinetics (blood trough concentration) becomes unnecessary. The present invention relates to a polymeric derivative of tacrolimus, in which a polyethylene glycol segment and an alcoholic hydroxy group of tacrolimus are bonded to side-chain carboxy groups of a polyaspartic acid derivative.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: March 16, 2021
    Assignee: Nippon Kayaku Kabushiki Kaisha
    Inventors: Nao Yoneki, Akihiro Sekiguchi, Kana Mizunuma, Yuki Kobayashi, Junpei Konno, Kan Saiga, Keiichirou Yamamoto
  • Polymer Derivative Of Macrolide Immunosuppressant
    Publication number: 20200155518
    Abstract: An object of the invention is to obtain a preparation which shows enhanced effectiveness and safety compared to tacrolimus, has the concentration in blood maintained at a constant level without individual differences, whereby the control of the amount of administration depending on the blood kinetics (blood trough concentration) becomes unnecessary. The present invention relates to a polymeric derivative of tacrolimus, in which a polyethylene glycol segment and an alcoholic hydroxy group of tacrolimus are bonded to side-chain carboxy groups of a polyaspartic acid derivative.
    Type: Application
    Filed: December 19, 2016
    Publication date: May 21, 2020
    Inventors: Nao Yoneki, Akihiro Sekiguchi, Kana Mizunuma, Yuki Kobayashi, Junpei Konno, Kan Saiga, Keiichirou Yamamoto
  • Polymeric Derivative Of Macrolide Immunosuppressant
    Publication number: 20180334540
    Abstract: A problem of the present invention is to obtain a preparation which shows markedly enhanced effectiveness and safety by exhibiting high accumulability at diseased areas and having the blood concentration maintained at a constant level without individual differences, and for which the control of the dosage depending on the blood kinetics (blood trough concentration) becomes unnecessary. The invention relates to a polymeric derivative of tacrolimus including a copolymer of a polyethylene glycol segment and a polymeric moiety, in which a carboxy group in a side chain of the copolymer is bonded to an alcoholic hydroxy group of tacrolimus.
    Type: Application
    Filed: November 10, 2016
    Publication date: November 22, 2018
    Inventors: Akihiro Sekiguchi, Kana Mizunuma, Keiichirou Yamamoto, Nao Yoneki, Tomohiro Hayashi, Kan Saiga, Junpei Konno, Yuki Kobayashi, Takamichi Sato, Naoko Igo, Kimiko Fuchigami