Patents by Inventor Naoaki Murao

Naoaki Murao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptide-compound cyclization method
    Patent number: 11891457
    Abstract: An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.
    Type: Grant
    Filed: September 3, 2020
    Date of Patent: February 6, 2024
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Shiori Kariyuki, Takeo Iida, Miki Kojima, Ryuichi Takeyama, Mikimasa Tanada, Tetsuo Kojima, Hitoshi Iikura, Atsushi Matsuo, Takuya Shiraishi, Takashi Emura, Kazuhiko Nakano, Koji Takano, Kousuke Asou, Takuya Torizawa, Ryusuke Takano, Nozomi Hisada, Naoaki Murao, Atsushi Ohta, Kaori Kimura, Yusuke Yamagishi, Tatsuya Kato
  • PEPTIDE-COMPOUND CYCLIZATION METHOD
    Publication number: 20210061860
    Abstract: An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.
    Type: Application
    Filed: September 3, 2020
    Publication date: March 4, 2021
    Applicant: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Shiori KARIYUKI, Takeo Ilda, Miki Kojima, Ryuichi Takeyama, Mikimasa Tanada, Tetsuo Kojima, Hitoshi Ilkura, Atsushi Matsuo, Takuya Shiraishi, Takashi Emura, Kazuhiko Nakano, Koji Takano, Kousuke Asou, Takuya Torizawa, Ryusuke Takano, Nozomi Hisada, Naoaki Murao, Atsushi Ohta, Kaori Kimura, Yusuke Yamagishi, Tatsuya Kato
  • PEPTIDE-COMPOUND CYCLIZATION METHOD
    Publication number: 20160311858
    Abstract: An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.
    Type: Application
    Filed: May 27, 2016
    Publication date: October 27, 2016
    Applicant: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Shiori Kariyuki, Takeo Iida, Miki Kojima, Ryuichi Takeyama, Mikimasa Tanada, Tetsuo Kojima, Hitoshi Iikura, Atsushi Matsuo, Takuya Shiraishi, Takashi Emura, Kazuhiko Nakano, Koji Takano, Kousuke Asou, Takuya Torizawa, Ryusuke Takano, Nozomi Hisada, Naoaki Murao, Atsushi Ohta, Kaori Kimura, Yusuke Yamagishi, Tatsuya Kato
  • Peptide-compound cyclization method
    Patent number: 9409952
    Abstract: An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: August 9, 2016
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Shiori Kariyuki, Takeo Iida, Miki Kojima, Ryuichi Takeyama, Mikimasa Tanada, Tetsuo Kojima, Hitoshi Iikura, Atsushi Matsuo, Takuya Shiraishi, Takashi Emura, Kazuhiko Nakano, Koji Takano, Kousuke Asou, Takuya Torizawa, Ryusuke Takano, Nozomi Hisada, Naoaki Murao, Atsushi Ohta, Kaori Kimura, Yusuke Yamagishi, Tatsuya Kato
  • PEPTIDE-COMPOUND CYCLIZATION METHOD
    Publication number: 20150080549
    Abstract: An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.
    Type: Application
    Filed: December 28, 2012
    Publication date: March 19, 2015
    Inventors: Shiori Kariyuki, Takeo Iida, Miki Kojima, Ryuichi Takeyama, Mikimasa Tanada, Tetsuo Kojima, Hitoshi Iikura, Atsushi Matsuo, Takuya Shiraishi, Takashi Emura, Kazuhiko Nakano, Koji Takano, Kousuke Asou, Takuya Torizawa, Ryusuke Takano, Nozomi Hisada, Naoaki Murao, Atsushi Ohta, Kaori Kimura, Yusuke Yamagishi, Tatsuya Kato
  • Ferrocene compound and use thereof
    Patent number: 7019146
    Abstract: The present invention provides a novel ferrocene compound; a reagent containing the compound; a high-sensitivity method of measuring a vitamin D compound using the reagent; etc. Specifically, a ferrocene compound represented by the following formula (1): is reacted with a vitamin D compound and the combined compound of these compounds is subjected to LC/ESI-MS/MS. Thus, the VD compound can be measured with higher sensitivity than in conventional techniques. The ferrocene compound of the present invention is extremely useful as a derivatization agent when a VD compound is measured by LC/ESI-MS/MS. The obtained compound wherein the ferrocene compound and the VD compound have been combined with each other, is useful as, e.g., a labeled compound, when the VD compound is measured by LC/ESI-MS/MS.
    Type: Grant
    Filed: June 27, 2003
    Date of Patent: March 28, 2006
    Assignee: Chugai Seiyaku Kabushiki Kaisya
    Inventors: Masaki Ishigai, Naoaki Murao, Nobuo Sekiguchi, Tadakatsu Takahashi