Patents by Inventor Naohiko Hirota

Naohiko Hirota has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240076275
    Abstract: Provided is a crystal of a specific oxazole compound that has specific inhibitory activity against PDE4, and that shows excellent stability. Specifically, provided is a crystal of an oxazole compound represented by formula (5) wherein the crystal has peaks at diffraction angles)2?(°) of 9.6±0.2, 19.1±0.2, and 21.2±0.2 in an X-ray powder diffraction pattern measured using CuK? characteristic X-rays.
    Type: Application
    Filed: October 31, 2023
    Publication date: March 7, 2024
    Applicant: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Naohiko Kanai, Takayuki Yasutomi, Ryosuke Hirota
  • Publication number: 20180271046
    Abstract: A barley plant including a mutant LOX-1 protein and that is deficient in lipoxygenase activity.
    Type: Application
    Filed: May 15, 2018
    Publication date: September 27, 2018
    Applicant: SAPPORO BREWERIES LIMITED
    Inventors: Naohiko HIROTA, Takafumi KANEKO, Hisao KURODA, Hirotaka KANEDA, Kiyoshi TAKOI, Kazuyoshi TAKEDA
  • Publication number: 20170295738
    Abstract: A barley plant including a mutant LOX-1 protein and that is deficient in lipoxygenase activity.
    Type: Application
    Filed: October 14, 2015
    Publication date: October 19, 2017
    Applicant: SAPPORO BREWERIES LIMITED
    Inventors: Naohiko HIROTA, Takafumi Kaneko, Hisao Kuroda, Hirotaka Kaneda, Kiyoshi Takoi, Kazuyoshi Takeda
  • Patent number: 9497919
    Abstract: A barley plant including a mutant LOX-1 protein and that is deficient in lipoxygenase activity.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: November 22, 2016
    Assignee: SAPPORO BREWERIES LIMITED
    Inventors: Naohiko Hirota, Takafumi Kaneko, Hisao Kuroda, Hirotaka Kaneda, Kiyoshi Takoi, Kazuyoshi Takeda
  • Publication number: 20150257354
    Abstract: A barley plant including a mutant LOX-1 protein and that is deficient in lipoxygenase activity
    Type: Application
    Filed: March 19, 2015
    Publication date: September 17, 2015
    Applicant: SAPPORO BREWERIES LIMITED
    Inventors: NAOHIKO HIROTA, TAKAFUMI KANEKO, HISAO KURODA, HIROTAKA KANEDA, KIYOSHI TAKOI, KAZUYOSHI TAKEDA
  • Patent number: 7897850
    Abstract: A selection method for barley lipoxygenase-1 deficient barley, comprising a step of distinguishing the barley lipoxygenase-1 deficient barley by whether or not the guanine at the splicing donor site of the 5th intron of the barley lipoxygenase-1 gene is mutated to a different base; and a method for production of malt alcoholic beverages using a material for malt alcoholic beverages derived from barley obtained by the selection method.
    Type: Grant
    Filed: March 25, 2004
    Date of Patent: March 1, 2011
    Assignee: Sapporo Breweries Limited
    Inventors: Naohiko Hirota, Takafumi Kaneko, Hisao Kuroda, Hirotaka Kaneda, Kiyoshi Takoi, Kazuyoshi Takeda
  • Publication number: 20090285932
    Abstract: A selection method for barley lipoxygenase-1 deficient barley, comprising a step of distinguishing the barley lipoxygenase-1 deficient barley by whether or not the guanine at the splicing donor site of the 5th intron of the barley lipoxygenase-1 gene is mutated to a different base; and a method for production of malt alcoholic beverages using a material for malt alcoholic beverages derived from barley obtained by the selection method.
    Type: Application
    Filed: July 20, 2009
    Publication date: November 19, 2009
    Applicant: SAPPORO BREWERIES LIMITED
    Inventors: Naohiko HIROTA, Takafumi Kaneko, Hisao Kuroda, Hirotaka Kaneda, Kiyoshi Takoi, Kazuyoshi Takeda
  • Publication number: 20080193593
    Abstract: A selection method for barley lipoxygenase-1 deficient barley, comprising a step of distinguishing the barley lipoxygenase-1 deficient barley by whether or not the guanine at the splicing donor site of the 5th intron of the barley lipoxygenase-1 gene is mutated to a different base; and a method for production of malt alcoholic beverages using a material for malt alcoholic beverages derived from barley obtained by the selection method.
    Type: Application
    Filed: March 25, 2004
    Publication date: August 14, 2008
    Inventors: Naohiko Hirota, Takafumi Kaneko, Hisao Kuroda, Hirotaka Kaneda, Kiyoshi Takoi, Kazuyoshi Takeda
  • Patent number: 7074986
    Abstract: In barley, the formation of D-hordein constituting gel protein is to be reduced. This reduction in the formation of D-hordein causes a reduction of gel protein because D-hordein fraction decreases in the gel protein; and in addition, it brings about the transformation (reduction) of proteins other than D-hordein which constitute the gel protein from the gel protein. Therefore, by introducing into barley D-hordein expression suppressing vector 1 capable of suppressing the D-hordein formation and transforming the barley therewith, it is possible to attain the reduction of gel protein based on the reduction in the D-hordein formation.
    Type: Grant
    Filed: August 16, 2000
    Date of Patent: July 11, 2006
    Assignee: Sapporo Breweries Limited
    Inventors: Naohiko Hirota, Makoto Kihara, Kazutoshi Ito
  • Patent number: 5955649
    Abstract: The present invention provides new gene expression regulatory DNA. This gene expression regulatory DNA comprises a promotor region derived from the barley D-hordein gene enabling the expression of a desired gene, and a regulatory region for regulating the expression of said gene based on said promoter region. This regulatory region consists at least of an activating region to activate the expression of said gene and a suppressing region to suppress the same.Use of this gene expression regulatory DNA enables controlling as desired the expression of gene within a plant cell such as barley.
    Type: Grant
    Filed: July 23, 1997
    Date of Patent: September 21, 1999
    Assignee: Sapporo Breweries Ltd.
    Inventors: Naohiko Hirota, Makoto Kihara, Hisao Kuroda, Kazutoshi Ito
  • Patent number: 5773688
    Abstract: cDNA derived from the ARF gene that is actively expressed in barley seeds, roots and callus, but is highly suppressed or almost not expressed at all in leaves, was cloned. Next, the upstream region of the ARF gene was cloned, its promoter activity was verified, and a gene expression vector using the expression region of this gene was produced.
    Type: Grant
    Filed: April 7, 1995
    Date of Patent: June 30, 1998
    Assignee: Sapporo Breweries Limited
    Inventors: Hisao Kuroda, Naohiko Hirota, Kazutoshi Ito