Patents by Inventor Naohiro Inohara

Naohiro Inohara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR INTESTINAL INFLAMMATION
    Publication number: 20230364162
    Abstract: Provided herein are compositions and methods for the management of intestinal inflammation. In particular, compositions comprising modified adherent-invasive E. coli (AIEC) are administered to human and/or animal subjects to treat, prevent or decrease susceptibility to intestinal inflammation.
    Type: Application
    Filed: September 28, 2021
    Publication date: November 16, 2023
    Inventors: Masashi Ohno, Gabriel Nunez, Naohiro Inohara, Mizuho Hasegawa
  • Modulators Of NOD1 Signaling
    Publication number: 20090035851
    Abstract: The present invention relates to intracellular signaling molecules, in particular the Nod1 protein. The present invention provides methods of identifying modulators of Nod1 signaling. The present invention further provides methods of altering Nod1 signaling.
    Type: Application
    Filed: March 31, 2008
    Publication date: February 5, 2009
    Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, OSAKA UNIVERSITY
    Inventors: Naohiro Inohara, Koichi Fukase, Yukari Fujimoto
  • Modulators Of NOD2 Signalling
    Publication number: 20080280367
    Abstract: The present invention relates to intracellular signaling molecules, in particular the Nod2 protein and nucleic acids encoding the Nod2 protein. The present invention provides methods of identifying modulators of Nod2 signaling. In particular, the present invention additionally provides methods of screening immune modulators such as adjuvants using Nod2. The present invention further provides methods of altering Nod2 signaling.
    Type: Application
    Filed: March 26, 2008
    Publication date: November 13, 2008
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Gabriel Nunez, Naohiro Inohara, Yasunori Ogura
  • Modulators of Nod2 signaling
    Patent number: 7375086
    Abstract: The present invention relates to intracellular signaling molecules, in particular the Nod2 protein and nucleic acids encoding the Nod2 protein. The present invention provides methods of identifying modulators of Nod2 signaling. In particular, the present invention additionally provides methods of screening immune modulators such as adjuvants using Nod2. The present invention further provides methods of altering Nod2 signaling.
    Type: Grant
    Filed: January 12, 2006
    Date of Patent: May 20, 2008
    Assignee: The Regents of the University of Michigan
    Inventors: Gabriel Nuñez, Naohiro Inohara, Yasunori Ogura
  • Method of screening modulators of Nod1 signaling
    Patent number: 7244557
    Abstract: The present invention relates to intracellular signaling molecules, in particular the Nod1 protein. The present invention provides methods of identifying modulators of Nod1 signaling. The present invention further provides methods of altering Nod1 signaling.
    Type: Grant
    Filed: May 14, 2004
    Date of Patent: July 17, 2007
    Assignee: Regents of the University of Michigan
    Inventors: Gabriel Nuñez, Naohiro Inohara
  • RICK3 nucleic acids and proteins
    Patent number: 7176019
    Abstract: The present invention related to methods and compositions for modulating cellular signaling. In particular, the present invention relates to PKK and RICK3 proteins. The present invention further relates the to use of PKK and RICK3 proteins in modulating NF-?B signaling. The present invention thus provides novel targets for drug screening and therapeutics.
    Type: Grant
    Filed: December 22, 2005
    Date of Patent: February 13, 2007
    Assignee: The Regents of the University of Michigan
    Inventors: Gabriel Nuñez, Naohiro Inohara, Akihiro Muto
  • NOD nucleic acids and polypeptides
    Publication number: 20060292590
    Abstract: The present invention relates to the NOD proteins and nucleic acids encoding the NOD proteins. The present invention further provides assays for the detection of NOD polymorphisms and mutations associated with disease states, as well as methods of screening for ligands and modulators of NOD proteins.
    Type: Application
    Filed: January 26, 2006
    Publication date: December 28, 2006
    Inventors: Naohiro Inohara, Gabriel Nunez
  • Modulators of Nod1 signaling
    Publication number: 20060258580
    Abstract: The present invention relates to intracellular signaling molecules, in particular the Nod1 protein. The present invention provides methods of identifying modulators of Nod1 signaling. The present invention further provides methods of altering Nod1 signaling.
    Type: Application
    Filed: October 13, 2005
    Publication date: November 16, 2006
    Applicants: Regents of the University of Michigan, Osaka University
    Inventors: Naohiro Inohara, Koichi Fukase, Yukari Fujimoto
  • Modulators of Nod2 signaling
    Publication number: 20060160118
    Abstract: The present invention relates to intracellular signaling molecules, in particular the Nod2 protein and nucleic acids encoding the Nod2 protein. The present invention provides methods of identifying modulators of Nod2 signaling. In particular, the present invention additionally provides methods of screening immune modulators such as adjuvants using Nod2. The present invention further provides methods of altering Nod2 signaling.
    Type: Application
    Filed: January 12, 2006
    Publication date: July 20, 2006
    Inventors: Gabriel Nunez, Naohiro Inohara, Yasunori Ogura
  • Nod2 nucleic acids and proteins
    Patent number: 7060493
    Abstract: The present invention relates to intracellular signalling molecules, in particular the Nod2 protein and nucleic acids encoding the Nod2 protein. The present invention provides isolated nucleotide sequence encoding Nod2, isolated Nod2 peptides, antibodies that specifically bind Nod2, methods for the detection of Nod2, and methods for screening compounds for the ability to alter Nod2 associated signal transduction.
    Type: Grant
    Filed: November 9, 2004
    Date of Patent: June 13, 2006
    Assignee: Regents of the University of Michigan
    Inventors: Gabriel Nunez, Naohiro Inohara, Yasunori Ogura
  • Modulators on Nod2 signaling
    Patent number: 7060442
    Abstract: The present invention relates to intracellular signaling molecules, in particular the Nod2 protein and nucleic acids encoding the Nod2 protein. The present invention provides methods of identifying modulators of Nod2 signaling. In particular, the present invention additionally provides methods of screening immune modulators such as adjuvants using Nod2. The present invention further provides methods of altering Nod2 signaling.
    Type: Grant
    Filed: December 9, 2002
    Date of Patent: June 13, 2006
    Assignee: Regents of the University of Michigan
    Inventors: Gabriel Nuñez, Naohiro Inohara, Yasunori Ogura
  • RICK3 nucleic acids and proteins
    Publication number: 20060105413
    Abstract: The present invention related to methods and compositions for modulating cellular signaling. In particular, the present invention relates to PKK and RICK3 proteins. The present invention further relates the to use of PKK and RICK3 proteins in modulating NF-?B signaling. The present invention thus provides novel targets for drug screening and therapeutics.
    Type: Application
    Filed: December 22, 2005
    Publication date: May 18, 2006
    Inventors: Gabriel Nunez, Naohiro Inohara, Akihiro Muto
  • NOD nucleic acids and polypeptides
    Patent number: 7041491
    Abstract: The present invention relates to the NOD proteins and nucleic acids encoding the NOD proteins. The present invention further provides assays for the detection of NOD polymorphisms and mutations associated with disease states, as well as methods of screening for ligands and modulators of NOD proteins.
    Type: Grant
    Filed: March 5, 2004
    Date of Patent: May 9, 2006
    Assignee: Regents of the University of Michigan
    Inventors: Naohiro Inohara, Gabriel Nuñez
  • NOD2 nucleic acids and proteins
    Publication number: 20050239105
    Abstract: The present invention relates to intracellular signalling molecules, in particular the Nod2 protein and nucleic acids encoding the Nod2 protein. The present invention provides isolated nucleotide sequence encoding Nod2, isolated Nod2 peptides, antibodies that specifically bind Nod2, methods for the detection of Nod2, and methods for screening compounds for the ability to alter Nod2 associated signal transduction.
    Type: Application
    Filed: November 9, 2004
    Publication date: October 27, 2005
    Inventors: Gabriel Nunez, Naohiro Inohara, Yasunori Ogura
  • Nod2 nucleic acids and proteins
    Patent number: 6858391
    Abstract: The present invention relates to intracellular signalling molecules, in particular the Nod2 protein and nucleic acids encoding the Nod2 protein. The present invention provides isolated nucleotide sequence encoding Nod2, isolated Nod2 peptides, antibodies that specifically bind Nod2, methods for the detection of Nod2, and methods for screening compounds for the ability to alter Nod2 associated signal transduction. The present invention also provides Nod2 variant alleles. The present invention further provides methods of identifying individuals at increased risk of developing Crohn's disease.
    Type: Grant
    Filed: October 26, 2001
    Date of Patent: February 22, 2005
    Assignee: Regents of the University of Michigan
    Inventors: Gabriel Nunez, Naohiro Inohara, Yasunori Ogura, Judy Cho, Dan L. Nicolae, Denise Bonen
  • Modulators of Nod1 signaling
    Publication number: 20050009065
    Abstract: The present invention relates to intracellular signaling molecules, in particular the Nod1 protein. The present invention provides methods of identifying modulators of Nod1 signaling. The present invention further provides methods of altering Nod1 signaling.
    Type: Application
    Filed: May 14, 2004
    Publication date: January 13, 2005
    Applicant: The Regents of the University of Michigan
    Inventors: Gabriel Nunez, Naohiro Inohara
  • Nod2 nucleic acids and proteins
    Patent number: 6835815
    Abstract: The present invention relates to intracellular signalling molecules, in particular the Nod2 protein and nucleic acids encoding the Nod2 protein. The present invention provides isolated nucleotide sequence encoding Nod2, isolated Nod2 peptides, antibodies that specifically bind Nod2, methods for the detection of Nod2, and methods for screening compounds for the ability to alter Nod2 associated signal transduction.
    Type: Grant
    Filed: October 26, 2001
    Date of Patent: December 28, 2004
    Assignee: Regents of the University of Michigan
    Inventors: Gabriel Nunez, Naohiro Inohara, Yasunori Ogura
  • NOD nucleic acids and polypeptides
    Publication number: 20040253615
    Abstract: The present invention relates to the NOD proteins and nucleic acids encoding the NOD proteins. The present invention further provides assays for the detection of NOD polymorphisms and mutations associated with disease states, as well as methods of screening for ligands and modulators of NOD proteins.
    Type: Application
    Filed: March 5, 2004
    Publication date: December 16, 2004
    Inventors: Naohiro Inohara, Gabriel Nunez
  • Methods and compositions for regulating cellular signaling
    Publication number: 20030199462
    Abstract: The present invention related to methods and compositions for modulating cellular signaling. In particular, the present invention relates to PKK and RICK3 proteins. The present invention further relates the to use of PKK and RICK3 proteins in modulating NF-&kgr;B signaling. The present invention thus provides novel targets for drug screening and therapeutics.
    Type: Application
    Filed: April 23, 2002
    Publication date: October 23, 2003
    Inventors: Gabriel Nunez, Naohiro Inohara, Akihiro Muto
  • Modulators on Nod2 signaling
    Publication number: 20030175762
    Abstract: The present invention relates to intracellular signaling molecules, in particular the Nod2 protein and nucleic acids encoding the Nod2 protein. The present invention provides methods of identifying modulators of Nod2 signaling. In particular, the present invention additionally provides methods of screening immune modulators such as adjuvants using Nod2. The present invention further provides methods of altering Nod2 signaling.
    Type: Application
    Filed: December 9, 2002
    Publication date: September 18, 2003
    Applicant: The Regents of the University of Michigan
    Inventors: Gabriel Nunez, Naohiro Inohara, Yasunori Ogura