Abstract: A probe for optical measurement is provided with an optical fiber, a ferrule in which an optical fiber is inserted such that one end of the optical fiber is exposed from one end of the ferrule and the other end side of the optical fiber is exposed from the other end of the ferrule, a cylindrical body sleeve having non-flexibility in which at least a part of the other end side of the ferrule is inserted, the body sleeve covering a part of the other end side of the optical fiber, and an optical fiber fixture filled in a gap between the optical fiber and the body sleeve and composed of a member formed by solidification of a material having fluidity.

Abstract: A probe for optical measurement is provided with an optical fiber, a ferrule in which an optical fiber is inserted such that one end of the optical fiber is exposed from one end of the ferrule and the other end side of the optical fiber is exposed from the other end of the ferrule, a cylindrical body sleeve having non-flexibility in which at least a part of the other end side of the ferrule is inserted, the body sleeve covering a part of the other end side of the optical fiber, and an optical fiber fixture filled in a gap between the optical fiber and the body sleeve and composed of a member formed by solidification of a material having fluidity.

Abstract: A head-up display apparatus is provided with an image emission mechanism that emits image display light, and a combiner arranged in front of an eye (or eyes) of a pilot to introduce the image display light to the eye(s) of the pilot. The head-up display apparatus is equipped with a light guide including first and second plane arranged in parallel planes, an incidence plane including a first reflector and an emission plane including a second reflector disposed between the first and second planes. The light guide is configured to reflect image display light from the emission mechanism to the combiner.

Abstract: A head-up display apparatus is provided with an image emission mechanism that emits image display light, and a combiner arranged in front of an eye (or eyes) of a pilot to introduce the image display light to the eye(s) of the pilot. The head-up display apparatus is equipped with a light guide including first and second plane arranged in parallel planes, an incidence plane including a first reflector and an emission plane including a second reflector disposed between the first and second planes. The light guide is configured to reflect image display light from the emission mechanism to the combiner.

Abstract: A head-mounted display (HMD) that enables a wearer to favorably view and recognize images even in a very bright environment, has a HMD in which image display light emitted from a display element is guided to an eye of an observer via a visor, whereby a virtual image of an observed subject is formed in front of the observer. In the HMD, light source devices are a first light source, outputting light of a high intensity, and a second light source, outputting light of a. low intensity. The light source devices have a switch to switch between the first and second light sources. The display element, the visor and the second light source are attached to a mount, worn on the head of the observer. The first light source is installed in a moveable body with the observer, and is connected to the mount via light transmission paths.

Abstract: A probe set comprising a detection probe and a counter probe, wherein the detection probe comprises an oligonucleotide which comprises a nucleotide sequence containing the mutation site on the target nucleic acid and also containing a nucleotide of interest in the mutation site or a nucleotide sequence complementary to the aforementioned nucleotide sequence, has a fluorescent substance added to the 5?-terminal and a quenching substance added to the 3?-terminal, and has, introduced therein, such a modification that the melting temperature of the probe becomes 3° C. or more higher than that of the counter probe, and wherein the counter probe comprises an oligonucleotide which comprises a nucleotide sequence containing a mutation site and also containing a nucleotide that is different from the nucleotide of interest in the mutation site or a nucleotide sequence complementary to the aforementioned nucleotide sequence.

Abstract: A head-mounted display (HMD) that enables a wearer to favorably view and recognize images even in a very bright environment, has a HMD in which image display light emitted from a display element is guided to an eye of an observer via a visor, whereby a virtual image of an observed subject is formed in front of the observer. In the HMD, light source devices are a first light source, outputting light of a high intensity, and a second light source, outputting light of a. low intensity. The light source devices have a switch to switch between the first and second light sources. The display element, the visor and the second light source are attached to a mount, worn on the head of the observer. The first light source is installed in a moveable body with the observer, and is connected to the mount via light transmission paths.

Abstract: A magnetic disk glass substrate manufacturing method includes a step of polishing a surface of a glass substrate to a mirror surface, a gas heating process step of causing a heated atmosphere and the glass substrate to contact each other so as to heat the glass substrate at a temperature T0, a step of causing a chemically strengthening salt melted exceeding a freezing temperature TF and the glass substrate to contact each other so as to chemically strengthen the glass substrate at a temperature T1, a gas cooling process step of causing a gas coolant and the glass substrate to contact each other so as to cool the glass substrate to a temperature T2, and a liquid cooling process step of causing a liquid coolant and the glass substrate to contact each other so as to cool the glass substrate to a temperature T3, the above-mentioned steps being included in this order, wherein the temperature T2 is set to a temperature less than the freezing temperature TF of the chemical strengthening salt in a gas cooling process

Abstract: Chemical strengthening treatment is performed by first providing a granular chemical strengthening salt so as to prevent spread in atmosphere at the time of introduction of chemical strengthening salt in a treating vessel, introducing the chemical strengthening salt in a treating vessel, melting the chemical strengthening salt into molten chemical strengthening salt and bringing a glass disc into contact with the molten chemical strengthening salt. The granular chemical strengthening salt is, for example, one obtained by forming of a powdery chemical strengthening salt material into grains. A chemically strengthened glass substrate for magnetic disk can be obtained through the process of carrying out chemical strengthening treatment of magnetic disk glass substrates. A magnetic disk can be obtained by forming at least a magnetic layer on the chemically strengthened glass substrate for magnetic disk.

Abstract: Chemical strengthening treatment is performed by first providing a granular chemical strengthening salt so as to prevent spread in atmosphere at the time of introduction of chemical strengthening salt in a treating vessel, introducing the chemical strengthening salt in a treating vessel, melting the chemical strengthening salt into molten chemical strengthening salt and bringing a glass disc into contact with the molten chemical strengthening salt. The granular chemical strengthening salt is, for example, one obtained by forming of a powdery chemical strengthening salt material into grains. A chemically strengthened glass substrate for magnetic disk can be obtained through the process of carrying out chemical strengthening treatment of magnetic disk glass substrates. A magnetic disk can be obtained by forming at least a magnetic layer on the chemically strengthened glass substrate for magnetic disk.

Abstract: A magnetic disk glass substrate manufacturing method includes a step of polishing a surface of a glass substrate to a mirror surface, a gas heating process step of causing a heated atmosphere and the glass substrate to contact each other so as to heat the glass substrate at a temperature T0, a step of causing a chemically strengthening salt melted exceeding a freezing temperature TF and the glass substrate to contact each other so as to chemically strengthen the glass substrate at a temperature T1, a gas cooling process step of causing a gas coolant and the glass substrate to contact each other so as to cool the glass substrate to a temperature T2, and a liquid cooling process step of causing a liquid coolant and the glass substrate to contact each other so as to cool the glass substrate to a temperature T3, the above-mentioned steps being included in this order, wherein the temperature T2 is set to a temperature less than the freezing temperature TF of the chemical strengthening salt in a gas cooling process

Abstract: A principal surface of a glass disk is mirror-polished. Then, the glass disk is subjected to a chemical treatment so as to remove a polishing-affected layer on the principal surface of the mirror-polished glass disk. Thereafter, a texture is formed on the principal surface of the glass disk by a tape. Thus, a glass substrate for a magnetic disk is obtained.

Abstract: 2-amino-6-arylthiopurinephosphonate used in the antiviral agent of the present invention has no toxicity such as bone marrow cell growth inhibition or mutagenicity, and has a high antiviral activity, oral absorbency and safety. Furthermore, the compound of the present invention is effective for a mutant virus which is known to exhibit resistance to the conventional antiviral agents. Therefore, the present invention can provide a useful antiviral agent which leads to the establishment of a method for treating hepatitis B, which is a medically important object.

Abstract: A compound represented by the following general formula (I) which has an antiviral activity: wherein R1 represents hydrogen atom, C1-C6 alkyl group, or C7-C10 aralkyl group; R2 represents C1-C6 alkyl group, C7-C10 aralkyl group, or phenyl group; R3 and R4 independently represent hydrogen atom, C1-C6 alkyl group, acyloxymethyl group, acylthioethyl group, or ethyl gorup substituted with at least one halogen atom; R5 represents hydrogen atom, C1-C4 alkyl gorup, C1-C4 hydroxyalkyl group, C1-C4 alkyl group substituted with at least one halogen atom; and X represents carbon atom or nitrogen atom.

Abstract: A phosphonate nucleotide compound represented by formula (I): (wherein R1 is a C1-C6 alkyl group or the like, R2 is a hydrogen atom, a C1-C4 alkyl group substituted by one or more halogen atoms or the like, R3 is a hydrogen atom, a C1-C4 alkyl group substituted by one or more halogen atoms or the like, R4 is a hydrogen atom, a C1-C4 alkyl group substituted by one or more halogen atoms and X is a carbon atom or a nitrogen atom), a salt thereof, a hydrate thereof or a solvate thereof, as well as a medicament containing the same. It is useful as an antiviral agent for human immunodeficiency virus, herpes simplex virus, hepatitis B virus or the like and as an antitumor agent.

Abstract: A phosphonate nucleotide compound having antiviral activity and is useful for an orally available and highly safe antiviral agent, which is represented by the following formula (I): ##STR1## wherein R.sup.1 represents hydrogen, a C.sub.1 -C.sub.6 alkoxy, a halogen-substituted C.sub.1 -C.sub.4 alkoxy, halogen, amino, or nitro; R.sup.2 and R.sup.3 independently represent hydrogen, a C.sub.1 -C.sub.22 alkyl, an acyloxymethy, an acylthioethyl, or a halogen-substituted ethyl; R.sup.4 represents hydrogen, a C.sub.1 -C.sub.4 alkyl, a C.sub.1 -C.sub.4 hydroxyalkyl, or a halogen-substituted C.sub.1 -C.sub.4 alkyl; and X represents carbon or nitrogen.