Patents by Inventor Naohisa Ninomiya
Naohisa Ninomiya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5621003Abstract: A maillard reaction inhibitor comprising, as the principal component, an eight-structural polymer of 3-oxygermylpropionic acid represented by the following stereostructure (I): ##STR1## wherein R represents --CH.sub.2 CH.sub.2 COOH, and m is a weight average polymerization degree calculated on the basis of the weight average molecular weight of propagermanium propyl ester and is 137.+-.84 (137 on average with a standard deviation of .+-.3.sigma.); and having the following minimum constitutional unit:(O.sub.1/2).sub.3 GeCH.sub.2 CH.sub.2 COOHand the following empirical formula:C.sub.6 H.sub.10 Ge.sub.2 O.sub.7,a method for inhibiting the Maillard reaction, and a method for preventing and treating diseases caused by Maillard reaction such as diabetes and concurrent diseases thereof.Type: GrantFiled: August 15, 1995Date of Patent: April 15, 1997Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.Inventors: Kiichi Sawai, Takahiko Mitani, Naohisa Ninomiya, Yoshiro Ishiwata
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Patent number: 5560925Abstract: Wart of human being is prevented or cured by administration of a pharmaceutical composition containing an eight structural polymer of 2-oxygermylpropionic acid having an empirical formula of C.sub.6 H.sub.10 Ge.sub.2 O.sub.7, a minimum constitutional unit of (O.sub.1/2).sub.3 GeCH.sub.2 CH.sub.2 COOH and the following stereostructure: ##STR1## wherein R stands for --CH.sub.2 CH.sub.2 COOH and m is an integer of 137.+-.84.Type: GrantFiled: October 3, 1994Date of Patent: October 1, 1996Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.Inventors: Kiichi Sawai, Takahiko Mitani, Naohisa Ninomiya, Yoshiro Ishiwata
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Patent number: 5532272Abstract: A novel, eight structural polymer of 2-oxygermylpropionic acid having an empirical formula of C.sub.6 H.sub.10 Ge.sub.2 O.sub.7, a minimum constitutional unit of (O.sub.1/2).sub.3 GeCH.sub.2 CH.sub.2 COOH and the following stereostructure: ##STR1## wherein R stands for --CH.sub.2 CH.sub.2 COOH and m is an integer of 137.+-.84. A pharmaceutical composition containing the novel polymer is useful for preventing symptoms of an immune disease such as hepatitis or for curing such a disease.Type: GrantFiled: May 20, 1994Date of Patent: July 2, 1996Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.Inventors: Kiichi Sawai, Takahiko Mitani, Naohisa Ninomiya, Yoshirou Ishiwata
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Patent number: 5260056Abstract: An organic germanium compound to be effectively used for curing AIDS or making AIDS asymtomatic in various forms is expressed by the following rational formula: ##STR1## wherein n is an integer of 1 or 2 or more, is in the form of a white acicular or needle crystal, shows a solubility of 1.570/100 ml in water at 25.degree. C. and exhibits a melting (decomposition) point of 240.degree. C.Type: GrantFiled: January 14, 1991Date of Patent: November 9, 1993Assignee: Sanwa Kagaku Kenkyusho Co. Ltd.Inventors: Kiichi Sawai, Masayasu Kurono, Takahiko Mitani, Naohisa Ninomiya, Yoshiro Ishiwata, Syoji Yokochi, Kyoichi Asano, Kaneo Yamada, Masashi Taki, Takashi Meguro, Mikio Minamitani, Takao Matumoto, Yuichi Shiokawa
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Patent number: 5240700Abstract: A composition for inhibiting the degeneration of cells including liver cells by drugs and relieving the toxicity of drugs to internal organs including the liver contains as an essential component a 3-oxygermylpropionic acid polymer which is represented by:[(O.sub.1/2).sub.3 GeCH.sub.2 CH.sub.2 COOH].sub.nwherein n is an integer of at least 1, takes the form of a white acicular crystal and has a melting point of about 230.degree. C. at which it decomposes or coagulates. The present composition may be used with a carrier hydroxypropylcellulose in an amount of 0.005 to 50% by weight relative to 0.005 to 5% by weight of the 3-oxygermylpropionic acid polymer.Type: GrantFiled: May 7, 1992Date of Patent: August 31, 1993Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.Inventors: Kiichi Sawai, Masayasu Kurono, Kazumasa Nakano, Kyoichi Asano, Takahiko Mitani, Naohisa Ninomiya, Bunkichi Kato
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Patent number: 5211956Abstract: Pharmaceutical compositions for oral administration used for the treatment and prevention of hyperlipemia, obesity and obesity-related diseases contain phytic acid or its salt as a pharmaceutically effective component.Type: GrantFiled: May 3, 1989Date of Patent: May 18, 1993Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.Inventors: Kiichi Sawai, Masayasu Kurono, Hiromoto Asai, Takahiko Mitani, Naohisa Ninomiya
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Patent number: 5166388Abstract: A stabilized composition of phytic acid is obtained by the steps of:heating and drying rice bran de-fatted by pressing;adding acidic water of pH 3 to 5 to the dried rice bran, stirring the solution and completing the stirring before the pH of the solution reaches 5.7; andheating the thus obtained liquid extract to solidify protein components, followed by the removal of the solid matters by filtration. This composition is advantageously used for removing uraroma and body odor.Type: GrantFiled: July 6, 1990Date of Patent: November 24, 1992Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.Inventors: Kiichi Sawai, Masayasu Kurono, Hiromoto Asai, Takahiko Mitani, Naohisa Ninomiya
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Patent number: 5118503Abstract: Composition obtained from a rice bran, which comprises a filtrate of lactic fermented and aged material of the rice bran, the filtrate being an odorless pale yellow solution, having a salty taste, and solubility with water and alcohols, or a powderized substance of the filtrate, a process for the preparation of the composition, and use of the composition as a deodorant.Type: GrantFiled: June 1, 1989Date of Patent: June 2, 1992Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.Inventors: Kiichi Sawai, Masayasu Kurono, Hiromoto Asai, Takahiko Mitani, Naohisa Ninomiya, Eiji Furukawa
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Patent number: 5089265Abstract: A stabilized phytic acid composition is provided, which comprises phytic acid or its salt and at least one stabilizer selected from the group consisting of a product obtained by the lactic fermentation and ripening of rice bran, a water-soluble polymer capable of forming a film and an additive capable of absorbing water.Type: GrantFiled: October 24, 1989Date of Patent: February 18, 1992Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.Inventors: Kiichi Sawai, Masayasu Kurono, Hiromoto Asai, Takahiko Mitani, Naohisa Ninomiya
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Patent number: 5059594Abstract: A novel composition contains phytic acid and ferric ions as main ingredients and carboxylic acid ions as a dissolution accelerator, and may further include at least one or more or two additives selected from the group consisting of a carboxylic acid or its salt, saccharides, an amino acid or its salt and an organic phosphoric acid or its salt.Type: GrantFiled: March 22, 1990Date of Patent: October 22, 1991Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.Inventors: Kiichi Sawai, Masayasu Kurono, Hiromoto Asai, Takahiko Mitani, Naohisa Ninomiya, Tomoo Suzuki
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Patent number: 5041429Abstract: Phytic acid or at least one of its salts is used as an effective component for cell activators in a hypoxic state, circulatory ameliorators, dementia remedies and edible compositions.Type: GrantFiled: May 22, 1989Date of Patent: August 20, 1991Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.Inventors: Kiichi Sawai, Masayasu Kurono, Hiromoto Asai, Takahiko Mitani, Motohide Hayashi, Tunematu Suzuki, Naohisa Ninomiya
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Patent number: 4952568Abstract: Remedies, preventives and functional diets for diabetic diseases, esp., diabetes, contain phytic acid or its salt or salts. The salt of phytic acid is a non-toxious metal salt, or a non-toxious salt with an organic base, a basic amino acid or an organic ester residue, and has a compositional form together with or separately from phytic acid.Type: GrantFiled: May 8, 1989Date of Patent: August 28, 1990Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.Inventors: Kiichi Sawai, Masayasu Kurono, Hiromoto Asai, Takahiko Mitani, Kazumasa Nakano, Naohisa Ninomiya
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Patent number: 4929438Abstract: Preventives or remedies for medicinal and alcoholic poisoning contain as a pharmaceutically effective component phytic acid or its salt which may be an innoxious metal salt, or an innoxious salt with an organic base, a basic amino acid or an organic ester residue.Type: GrantFiled: February 15, 1989Date of Patent: May 29, 1990Assignee: Kabushiki Kaisha Sanwa Kagaku KenkyushoInventors: Kiichi Sawai, Masayasu Kurono, Hiromiotu Asai, Takahiko Mitani, Naohisa Ninomiya, Takao Sugiyama, Eiji Furukawa, Hisashi Michishita