Abstract: Provided is a novel compound or salt thereof that induces degradation by autophagy of an intracellular molecule. In this compound, a ligand having activity to bind to an intracellular molecule and a structure having activity to induce autophagy of an intracellular molecule are linked via a linker without loss of the activity of the ligand and the structure.

Abstract: The present invention relates to compound (I) or a salt thereof which has a ROR?t inhibitory action. In the formula (I), each symbol is as defined in the specification.

Abstract: A treatment device and a treatment method are capable of improving permeability of a physiologically active substance into a blood vessel wall while maintaining a blood flow. A treatment device for treating a lesion in a blood vessel includes: a shaft portion including at least one lumen; a balloon disposed at a distal side of the shaft portion and configured to inflate; and at least one anchor member that can be inserted into the lumen and to radially expand at a state in which a distal portion protrudes from the lumen. The balloon has an outer diameter when inflated that is smaller than an outer diameter of the anchor member when radially expanded. When the anchor member radially expands in a blood vessel to come into contact with a blood vessel wall, the balloon is held away from the blood vessel wall.

Abstract: A medicine injection catheter includes: a catheter main body formed with a medicine supply lumen; a tubular body connected to the distal end of the catheter main body and having a lumen communicating with the medicine supply lumen; an injection needle connected to the tubular body; a tubular cover member that accommodates the tubular body and that is configured to be advanced and retracted in the axial direction of the catheter main body between a first position where a distal end of the injection needle is accommodated in the tubular cover and a second position where the distal end of the injection needle protrudes forward from the inside space; a closing member to close and open the lumen of the tubular body, a motion conversion mechanism which converts advancing/retracting motion of the cover member into movement of the closing member to close the lumen of the tubular body.

Abstract: A vehicle transmission structure of an embodiment includes a shift drum which rotates in accordance with a shift operation; a bearing member which rotatably supports the shift drum with respect to a transmission case; a set member which positions the bearing member; a shift fork shaft supported by the transmission case; and a shift fork supported by the shift fork shaft to be movable in an axial direction. An end portion of the shift fork shaft is movably fitted to an insertion hole provided in the transmission case, a cap is provided at an end portion of the shift fork shaft, a first gap is provided between an end surface of the insertion hole and the cap, the set member is disposed at a position overlapping the insertion hole when viewed in the axial direction, and a second gap is provided between an end surface of the insertion hole and the set member.

Abstract: The present invention relates to compound (I) or a salt thereof which has a ROR?t inhibitory action. In the formula (I), each symbol is as defined in the specification.

Abstract: A drug supply device for supplying drug to a living body surface that includes a shaft and a drug holding sheet attached to the distal end of the shaft. The drug holding sheet has a first face that faces distally and a second face opposite the first face that faces proximally when the drug holding sheet is expanded. The drug holding sheet includes folded portions that fold such that the first face is positioned to face radially inward while exposing the second face to an outside environment when the drug holding sheet is in a folded state. A drug is applied on the first face of the drug holding sheet. The drug supply device includes an expandable member on the second face of the drug holding sheet. The expandable member is expandable to cause the drug holding sheet to expand from the folded state into the expanded state.

Abstract: The present invention relates to compound (I) or a salt thereof which has a ROR?t inhibitory action. In the formula (I), each symbol is as defined in the specification.

Abstract: A sound output controlling method including a first projector that projects a first image on a projection surface via a first focusing lens and outputs sound based on a sound signal and a second projector that projects a second image on the projection surface via a second focusing lens and outputs sound based on the sound signal, causing the second projector to set the position of the second focusing lens based on the focused state of the second image on the projection surface and transmit position information on the position of the second focusing lens and causing the first projector to receive the position information, set the position of the first focusing lens based on the focused state of the first image on the projection surface, and control the output of the sound from the first projector based on the position information and the position of the first focusing lens.

Abstract: A drug supply device for supplying drug to a living body surface that includes a shaft and a drug holding sheet attached to the distal end of the shaft. The drug holding sheet has a first face that faces distally and a second face opposite the first face that faces proximally when the drug holding sheet is expanded. The drug holding sheet includes folded portions that fold such that the first face is positioned to face radially inward while exposing the second face to an outside environment when the drug holding sheet is in a folded state. A drug is applied on the first face of the drug holding sheet. The drug supply device includes an expandable member on the second face of the drug holding sheet. The expandable member is expandable to cause the drug holding sheet to expand from the folded state into the expanded state.

Abstract: A medical apparatus for joining body lumens in a living body includes a puncture member having a lumen, a distal opening portion and a needle tip at the distal end of the lumen. The needle tip can puncture a tube wall of the body lumen to form a puncture site. The medical apparatus includes a tubular member in the lumen of the puncture member that expands radially outward and contracts radially inward and a plunger movable relative to the puncture member to release the tubular member from the distal opening portion of the puncture member. The tubular member expands to be fixed to the puncture site when the tubular member is released from the distal opening portion of the puncture member.

Abstract: A sound output controlling method including a first projector that projects a first image on a projection surface via a first focusing lens and outputs sound based on a sound signal and a second projector that projects a second image on the projection surface via a second focusing lens and outputs sound based on the sound signal, causing the second projector to set the position of the second focusing lens based on the focused state of the second image on the projection surface and transmit position information on the position of the second focusing lens and causing the first projector to receive the position information, set the position of the first focusing lens based on the focused state of the first image on the projection surface, and control the output of the sound from the first projector based on the position information and the position of the first focusing lens.

Abstract: A vehicle transmission structure of an embodiment includes a shift drum which rotates in accordance with a shift operation; a bearing member which rotatably supports the shift drum with respect to a transmission case; a set member which positions the bearing member; a shift fork shaft supported by the transmission case; and a shift fork supported by the shift fork shaft to be movable in an axial direction. An end portion of the shift fork shaft is movably fitted to an insertion hole provided in the transmission case, a cap is provided at an end portion of the shift fork shaft, a first gap is provided between an end surface of the insertion hole and the cap, the set member is disposed at a position overlapping the insertion hole when viewed in the axial direction, and a second gap is provided between an end surface of the insertion hole and the set member.

Abstract: Provided is a novel compound or salt thereof that induces degradation by autophagy of an intracellular molecule. In this compound, a ligand having activity to bind to an intracellular molecule and a structure having activity to induce autophagy of an intracellular molecule are linked via a linker without loss of the activity of the ligand and the structure.

Abstract: The present invention relates to compound (I) or a salt thereof which has a ROR?t inhibitory action. In the formula (I), each symbol is as defined in the specification.

Abstract: The present invention relates to compound (I) or a salt thereof which has a ROR?t inhibitory action. In the formula (I), each symbol is as defined in the specification.

Abstract: The present invention provides a heterocyclic compound having a HDAC inhibitory action, and useful for the treatment of inflammatory disease and the like, and a medicament comprising the compound. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

Abstract: The present invention provide a heterocyclic compound having a HDAC inhibitory action, and useful for the treatment of autoimmune diseases and/or inflammatory diseases, graft versus host disease, cancers, central nervous diseases including neurodegenerative diseases, Charcot-Marie-Tooth disease and the like, and a medicament comprising the compound. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

Abstract: The present invention provide a heterocyclic compound having a HDAC inhibitory action, and useful for the treatment of autoimmune diseases and/or inflammatory diseases, graft versus host disease, cancers, central nervous diseases including neurodegenerative diseases, Charcot-Marie-Tooth disease and the like, and a pharmaceutical composition comprising the compound. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

Abstract: A medicine injecting catheter includes a catheter body having a medicine supply lumen, a tubular body coupled to a distal end of the catheter body and having a lumen fluidly communicating with the medicine supply lumen, an injection needle connected to a distal end of the tubular body, a cover member having an interior housing the tubular body, with the cover member disposed on the distal end of the catheter body for reciprocating axial movement between a first position in which the distal end of the needle is in the inner space and a second position in which the distal end of the needle projects forwardly from the inner space, and an opening/closing mechanism for opening/closing the tubular body lumen depending on an angular position of an operating member, and a motion converting mechanism for converting reciprocating movement of the cover member into rotary movement of the operating member.