Abstract: A main spindle device for a machine tool includes a main spindle, a cushioning member, and an arithmetic unit. The cushioning member is disposed on a position where a vibration displacement of a rotator exists. The arithmetic unit uses data of a tool to be used to analyze a vibration mode in a free vibration of the rotator based on a support rigidity of a bearing, masses of respective parts of the rotator including the tool, an attenuation coefficient, and an equation of motion derived from rigidity and inertia by a rotation. An outer diameter of a sleeve positioned outside the bearing is changed such that a position of an antinode of the vibration or a position on which a vibration displacement exists in the vibration mode matches a position of the cushioning member inside the main spindle to change a preload on the bearing.

Abstract: A tool pot includes a resin-made pot body and a metallic reinforcing member embedded in the pot body by insert molding. The reinforcing member is provided with a reinforcing plate embedded in a portion including a horizontal pin insertion portion in the pot body. The reinforcing plate is provided with a lightening hole so as to avoid the horizontal pin insertion portion.

Abstract: A main spindle failure detection device for a machine tool includes a rotation speed detection unit, a reach time estimation unit, and a determining unit. The reach time estimation unit is configured to estimate a reach time in which the rotation speed of the main spindle reaches a predetermined rotation speed threshold using a non-linear model based on a rotation speed of the main spindle detected at a start of an inertia operation and a rotation speed of the main spindle detected after an elapse of preset measurement time from the start of the inertia operation. The determining unit is configured to compare the reach time estimated by the reach time estimation unit with a preset reach time in which the rotation speed reaches the rotation speed threshold, so as to determine a failure in the main spindle based on a result of the comparison.

Abstract: A bearing diagnostic device senses a failure in a bearing of a machine tool including a rotation shaft device. The bearing diagnostic device includes a rotation counting unit, a temperature measuring unit, a frictional torque calculating unit, a rolling speed calculating unit, a bearing characteristic calculating unit, a storage unit, and a determination unit. The frictional torque calculating unit is configured to calculate a frictional torque of the rotation shaft device. The rolling speed calculating unit is configured to calculate a rolling speed of the bearing from the count of rotations. The bearing characteristic calculating unit is configured to calculate a bearing characteristic from the frictional torque and the rolling speed. The determination unit is configured to compare the bearing characteristic calculated by the bearing characteristic calculating unit with a reference bearing characteristic stored in the storage unit to determine a presence of a failure.

Abstract: A main spindle device for a machine tool includes a main spindle, a cushioning member, and an arithmetic unit. The cushioning member is disposed on a position where a vibration displacement of a rotator exists. The arithmetic unit uses data of a tool to be used to analyze a vibration mode in a free vibration of the rotator based on a support rigidity of a bearing, masses of respective parts of the rotator including the tool, an attenuation coefficient, and an equation of motion derived from rigidity and inertia by a rotation. An outer diameter of a sleeve positioned outside the bearing is changed such that a position of an antinode of the vibration or a position on which a vibration displacement exists in the vibration mode matches a position of the cushioning member inside the main spindle to change a preload on the bearing.

Abstract: A main spindle failure detection device for a machine tool includes a rotation speed detection unit, a reach time estimation unit, and a determining unit. The reach time estimation unit is configured to estimate a reach time in which the rotation speed of the main spindle reaches a predetermined rotation speed threshold using a non-linear model based on a rotation speed of the main spindle detected at a start of an inertia operation and a rotation speed of the main spindle detected after an elapse of preset measurement time from the start of the inertia operation. The determining unit is configured to compare the reach time estimated by the reach time estimation unit with a preset reach time in which the rotation speed reaches the rotation speed threshold, so as to determine a failure in the main spindle based on a result of the comparison.

Abstract: A bearing diagnostic device senses a failure in a bearing of a machine tool including a rotation shaft device. The bearing diagnostic device includes a rotation counting unit, a temperature measuring unit, a frictional torque calculating unit, a rolling speed calculating unit, a bearing characteristic calculating unit, a storage unit, and a determination unit. The frictional torque calculating unit is configured to calculate a frictional torque of the rotation shaft device. The rolling speed calculating unit is configured to calculate a rolling speed of the bearing from the count of rotations. The bearing characteristic calculating unit is configured to calculate a bearing characteristic from the frictional torque and the rolling speed. The determination unit is configured to compare the bearing characteristic calculated by the bearing characteristic calculating unit with a reference bearing characteristic stored in the storage unit to determine a presence of a failure.

Abstract: A tool pot includes a resin-made pot body and a metallic reinforcing member embedded in the pot body by insert molding. The reinforcing member is provided with a reinforcing plate embedded in a portion including a horizontal pin insertion portion in the pot body. The reinforcing plate is provided with a lightening hole so as to avoid the horizontal pin insertion portion.

Abstract: The present invention relates to an agent for increasing BMD characterized by use of a cathepsin K inhibitor as a bone resorption inhibitor in combination with a type of PTH as a bone formation stimulator. This agent for increasing BMD is useful for the treatment of osteoporosis, bone fracture, arthritis, rheumatoid arthritis, osteoarthritis, hypercalcemia, osteometastasis of carcinoma, periodontal disease, bone Paget's disease and other bone metabolic diseases. For example, as the cathepsin K inhibitor, there can be mentioned a compound of formula (W) and a salt thereof, etc.

Abstract: The present invention relates to an agent for increasing BMD characterized by use of a cathepsin K inhibitor as a bone resorption inhibitor in combination with a type of PTH as a bone formation stimulator. This agent for increasing BMD is useful for the treatment of osteoporosis, bone fracture, arthritis, rheumatoid arthritis, osteoarthritis, hypercalcemia, osteometastasis of carcinoma, periodontal disease, bone Paget's disease and other bone metabolic diseases. For example, as the cathepsin K inhibitor, there can be mentioned a compound of formula (W) and a salt thereof, etc.

Abstract: The present invention relates to a compound of formula (I) wherein Y and Z each is independently N or C; ring A is a carbocyclic group or a heterocyclic group; ring B is a heterocyclic group containing at least one nitrogen atom; R is a hydrogen atom, a substitutent, etc.; n is 0, or an integer of from 1 to 10, a salt thereof, a solvate thereof, or an N-oxide thereof, or a prodrug thereof. The compound of formula (I), a salt thereof, a solvate thereof, or an N-oxide thereof, or a prodrug thereof has an inhibitory activity against cysteine protease, and it is useful for the prophylaxis and/or treatment of a cysteine protease-related disease such as osteoporosis, etc.

Abstract: Secondary alcohol dehydrogenase having broad specificity to substrates and high stereoselectivity is provided. By reducing ketones using the enzyme, alcohols, particularly, optically active alcohols are efficiently produced. Ketones are also efficiently produced by oxidizing alcohols using the enzyme.

Abstract: The present invention provides a novel secondary alcohol dehydrogenase useful for the synthesis of optically active alcohol and DNA encoding said enzyme. A microorganism belonging to genus Candida was found to produce a novel secondary alcohol dehydrogenase with a high stereochemical specificity. Using said enzyme, optically active alcohols were prepared, and by cloning of DNA encoding said enzyme, the base sequence of said DNA was determined. By providing a novel secondary alcohol dehydrogenase with a high stereochemical specificity and the gene encoding said enzyme, an efficient production of optically active alcohols became possible.

Abstract: Optically active 1,2,4-butanetriol of high optical purity can be produced economically and simply using a microorganism capable of increasing the content of (S)-1,2,4-butanetriol or (R)-1,2,4-butanetriol by acting on a mixture of enantiomers of 1,2,4-butanetriol.

Abstract: Tyrosine decarboxylase, or microorganisms of the genuses Enterococcus, Lactobacillus, Providencia, Fusarium, and Gibberella were reacted with a mixture of the enantiomers of threo-3-phenylserine or its halogen substitution products to produce (R)-2-amino-1-phenylethanol or its halogen substitution products. At the same time, one of the enantiomers of threo-3-phenylserine or its halogen substitution products were selectively left, and optically active threo-3-phenylserine or its halogen substitution products were produced. In addition, a novel material of 3-(3-chlorophenyl)serine, which is a substrate of the reaction in the present invention, was produced. (R)-2-amino-1-phenylethanol or its halogen substitution products, and optically active threo-3-phenylserine or its halogen substitution products can economically be produced on an industrial scale.

Abstract: Tyrosine decarboxylase, or microorganisms of the genuses Enterococcus, Lactobacillus, Providencia, Fusarium, and Gibberella were reacted with a mixture of the enantiomers of threo-3-phenylserine or its halogen substitution products to produce (R)-2-amino-1-phenylethanol or its halogen substitution products. At the same time, one of the enantiomers of threo-3-phenylserine or its halogen substitution products were selectively left, and optically active threo-3-phenylserine or its halogen substitution products were produced. In addition, a novel material of 3-(3-chlorophenyl)serine, which is a substrate of the reaction in the present invention, was produced. (R)-2-amino-1-phenylethanol or its halogen substitution products, and optically active threo-3-phenylserine or its halogen substitution products can economically be produced on an industrial scale.

Abstract: The present invention provides a novel secondary alcohol dehydrogenase useful for the synthesis of optically active alcohol and DNA encoding said enzyme. A microorganism belonging to genus Candida was found to produce a novel secondary alcohol dehydrogenase with a high stereochemical specificity. Using said enzyme, optically active alcohols were prepared, and by cloning of DNA encoding said enzyme, the base sequence of said DNA was determined. By providing a novel secondary alcohol dehydrogenase with a high stereochemical specificity and the gene encoding said enzyme, an efficient production of optically active alcohols became possible.

Abstract: Tyrosine decarboxylase, or microorganisms of the genuses Enterococcus, Lactobacillus, Providencia, Fusarium, and Gibberella were reacted with a mixture of the enantiomers of threo-3-phenylserine or its halogen substitution products to produce (R)-2-amino-1-phenylethanol or its halogen substitution products. At the same time, one of the enantiomers of threo-3-phenylserine or its halogen substitution products were selectively left, and optically active threo-3-phenylserine or its halogen substitution products were produced. In addition, a novel material of 3-(3-chlorophenyl)serine, which is a substrate of the reaction in the present invention, was produced. (R)-2-amino-1-phenylethanol or its halogen substitution products, and optically active threo-3-phenylserine or its halogen substitution products can economically be produced on an industrial scale.

Abstract: A process for the asymmetric synthesis of a compound represented by general formula (II-R) easily at a low cost by using a lipase, and a process for producing a compound to be utilized in the above synthesis.