Patents by Inventor Naoki Midoh

Naoki Midoh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Midecamycin biosynthesis genes
    Patent number: 7795001
    Abstract: The present invention provides an isolated polypeptide comprising a nucleotide sequence encoding a protein which is involved in midecamycin biosynthesis, wherein the protein contains an amino acid sequence selected from SEQ ID NOs: 2 to 10, 13, 14, 16, 19, 20, 22 to 26, and 28 to 38 or a modified amino acid sequence of the amino acid sequence having one or more amino acid modifications without affecting activity of the protein.
    Type: Grant
    Filed: January 12, 2006
    Date of Patent: September 14, 2010
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Naoki Midoh, Shigeru Hoshiko, Takeshi Murakami
  • Cyclic depsipeptide synthetase and method for recombinant production
    Patent number: 7285404
    Abstract: The present invention provides an enzyme that synthesizes a cyclic depsipeptide, particularly the substance 1022, and a gene thereof. A cyclic depsipeptide synthetase according to the present invention comprises (a) an amino acid sequence of SEQ ID NO: 2 or (b) a modified amino acid sequence of the amino acid sequence of SEQ ID NO: 2 that have one or more modifications selected from a substitution, a deletion, an addition and an insertion and has cyclic depsipeptide synthetase activity. A cyclic depsipeptide synthetase gene according to the present invention comprises a nucleotide sequence encoding a cyclic depsipeptide synthetase. The present invention also provides a recombinant vector and a transformant for expressing the cyclic depsipeptide synthetase, and a mass production system for the cyclic depsipeptide. The present invention further provides a method for producing the cyclic depsipeptide synthetase.
    Type: Grant
    Filed: September 7, 2000
    Date of Patent: October 23, 2007
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Naoki Midoh, Kaoru Okakura, Koichi Miyamoto, Manabu Watanabe, Koji Yanai, Tetsuya Yasutake, Sato Aihara, Takafumi Futamura, Horst Kleinkauf, Takeshi Murakami
  • Transformant producing secondary metabolite modified with functional group and novel biosynthesis genes
    Patent number: 7109018
    Abstract: An objective of the present invention is to provide a transformant altered so as to produce a secondary metabolite in which a benzene ring of the secondary product is modified at the para-position with a functional group containing a nitrogen atom.
    Type: Grant
    Filed: September 29, 2000
    Date of Patent: September 19, 2006
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Koji Yanai, Kaoru Okakura, Shohei Yasuda, Manabu Watanabe, Koichi Miyamoto, Naoki Midoh, Takeshi Murakami
  • Midecamycin biosynthetic genes
    Patent number: 7070980
    Abstract: The present invention provides an isolated polypeptide comprising a nucleotide sequence encoding a protein which is involved in midecamycin biosynthesis, wherein the protein contains an amino acid sequence selected from SEQ ID NOs: 2 to 10, 13, 14, 16, 19, 20, 22 to 26, and 28 to 38 or a modified amino acid sequence of the amino acid sequence having one or more amino acid modifications without affecting activity of the protein.
    Type: Grant
    Filed: August 28, 2002
    Date of Patent: July 4, 2006
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Naoki Midoh, Shigeru Hoshiko, Takeshi Murakami
  • Midecamycin biosynthesis genes
    Publication number: 20060121577
    Abstract: The present invention provides an isolated polypeptide comprising a nucleotide sequence encoding a protein which is involved in midecamycin biosynthesis, wherein the protein contains an amino acid sequence selected from SEQ ID NOs: 2 to 10, 13, 14, 16, 19, 20, 22 to 26, and 28 to 38 or a modified amino acid sequence of the amino acid sequence having one or more amino acid modifications without affecting activity of the protein.
    Type: Application
    Filed: January 12, 2006
    Publication date: June 8, 2006
    Applicant: MEIJI SEIKA KAISHA, LTD.
    Inventors: Naoki Midoh, Shigeru Hoshiko, Takeshi Murakami
  • (R)-2-hydroxy-3-phenylpropionate (d-phenyllactate) dehydrogenase and gene encoding the same
    Patent number: 6916641
    Abstract: An objective of the present invention is to provide a D-phenyllactic acid dehydrogenase. Another objective of the present invention is to provide a gene which encodes the D-phenyllactic acid dehydrogenase. A D-phenyllactic acid dehydrogenase according to the present invention is a protein comprising an amino acid sequence of the amino acid sequence of SEQ ID NO: 2 or a modified amino acid sequence of the amino acid sequence of SEQ ID NO: 2 that has one or more modifications selected from a substitution, a deletion, an addition and an insertion and has D-phenyllactic acid dehydrogenase activity. A D-phenyllactic acid dehydrogenase gene according to the present invention comprises a nucleotide sequence which encodes the D-phenyllactic acid dehydrogenase, for example the nucleotide sequence of SEQ ID NO: 1.
    Type: Grant
    Filed: April 26, 2001
    Date of Patent: July 12, 2005
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Koichi Miyamoto, Naomi Sumida, Naoki Midoh, Takeshi Murakami, Rainer Zocher, Horst Kleinkauf
  • Midecamycin biosynthetic genes
    Publication number: 20040091975
    Abstract: The present invention provides an isolated polypeptide comprising a nucleotide sequence encoding a protein which is involved in midecamycin biosynthesis, wherein said protein comprises an amino acid sequence selected from SEQ ID NOs: 2 to 10, 13, 14, 16, 19, 20, 22 to 26, and 28 to 38 or a modified amino acid sequence of said amino acid sequence having one or more amino acid modifications without affecting activity of the protein.
    Type: Application
    Filed: August 28, 2002
    Publication date: May 13, 2004
    Applicant: MEIJI SEIKA KAISHA, LTD.
    Inventors: Naoki Midoh, Shigeru Hoshiko, Takeshi Murakami
  • Novel (r)-2-hydroxy-3-phenylpropionate (d-phenyllactate) dehydrogenase and gene encoding the same
    Publication number: 20030186410
    Abstract: An objective of the present invention is to provide a D-phenyllactic acid dehydrogenase. Another objective of the present invention is to provide a gene which encodes the D-phenyllactic acid dehydrogenase. A D-phenyllactic acid dehydrogenase according to the present invention is a protein comprising an amino acid sequence of the amino acid sequence of SEQ ID NO: 2 or a modified amino acid sequence of the amino acid sequence of SEQ ID NO: 2 that has one or more modifications selected from a substitution, a deletion, an addition and an insertion and has D-phenyllactic acid dehydrogenase activity. A D-phenyllactic acid dehydrogenase gene according to the present invention comprises a nucleotide sequence which encodes the D-phenyllactic acid dehydrogenase, for example the nucleotide sequence of SEQ ID NO: 1.
    Type: Application
    Filed: November 7, 2002
    Publication date: October 2, 2003
    Inventors: Koichi Miyamoto, Naomi Sumida, Naoki Midoh, Takeshi Murakami, Rainer Zocher, Horst Kleinkauf