Abstract: An objective is to identify the health state of mechanical equipment and provide information usable for determining maintenance work timing or the like. A health management system includes a time-series data acquisition unit configured to acquire multi-dimensional sensor data and environmental data from mechanical equipment; a first discrimination unit configured to quantify the equipment state of the mechanical equipment by a statistical method using normal data as learning data; a second discrimination unit configured to quantify the health state indicating the performance or quality of the mechanical equipment by a statistical method using normal data; and an output unit configured to display and/or output to the outside the quantified equipment state and health state.

Abstract: The present invention provides agents for treating or preventing diseases such as mood disorder, anxiety disorder, schizophrenia, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastrointestinal disease, drug addiction, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, head injury, inflammation, immune-related disease, alopecia, and so forth.

Abstract: The anomaly diagnosis system includes the state measure calculator acquiring sensor data from sensors in a machine facility as time series data; an approximation formula calculator calculating a state measure being an index indicating a state of the machine facility, such as anomaly and a performance by a statistical method in which the time series data is used as learned data; and a state measure estimating unit estimating the state measures until future time using the approximation formula. Whenever the latest time series data is acquired, the reference period in which the time series data corresponding to the state measure referred to calculate the approximation formula by the reference period setting unit, is successively extended by addition of time when the latest time series data is acquired. The approximation formula calculator calculates the approximation formula using the state measure of the time series data acquired in the reference period.

Abstract: Provided are a fluorine-containing amino acid prodrug represented by general formula (I) that makes a fluorine-containing amino acid which is a group 2 metabotropic glutamate receptor agonist into a prodrug, or a pharmaceutically acceptable salt thereof.

Abstract: The anomaly diagnosis system includes the state measure calculator acquiring sensor data from sensors in a machine facility as time series data; an approximation formula calculator calculating a state measure being an index indicating a state of the machine facility, such as anomaly and a performance by a statistical method in which the time series data is used as learned data; and a state measure estimating unit estimating the state measures until future time using the approximation formula. Whenever the latest time series data is acquired, the reference period in which the time series data corresponding to the state measure referred to calculate the approximation formula by the reference period setting unit, is successively extended by addition of time when the latest time series data is acquired. The approximation formula calculator calculates the approximation formula using the state measure of the time series data acquired in the reference period.

Abstract: The present invention provides a 1,2,4-triazolone derivative represented by Formula (1A) having an antagonistic activity on the arginine-vasopressin 1b receptor or a pharmaceutically acceptable salt thereof and provides a pharmaceutical composition comprising the compound or the salt as an active ingredient, in particular, a therapeutic or preventive agent exhibiting favorable pharmacokinetics in a disease such as mood disorder, anxiety disorder, schizophrenia, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastrointestinal disease, drug addiction, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, head injury, inflammation, immune-related disease, or alopecia.

Abstract: An objective is to identify the health state of mechanical equipment and provide information usable for determining maintenance work timing or the like. A health management system includes a time-series data acquisition unit configured to acquire multi-dimensional sensor data and environmental data from mechanical equipment; a first discrimination unit configured to quantify the equipment state of the mechanical equipment by a statistical method using normal data as learning data; a second discrimination unit configured to quantify the health state indicating the performance or quality of the mechanical equipment by a statistical method using normal data; and an output unit configured to display and/or output to the outside the quantified equipment state and health state.

Abstract: Provided are a fluorine-containing amino acid prodrug represented by general formula (I) that makes a fluorine-containing amino acid which is a group 2 metabotropic glutamate receptor agonist into a prodrug, or a pharmaceutically acceptable salt thereof.

Abstract: The present invention provides agents for treating or preventing diseases such as mood disorder, anxiety disorder, schizophrenia, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastrointestinal disease, drug addiction, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, head injury, inflammation, immune-related disease, alopecia, and so forth.

Abstract: A multi-piece solid golf ball has a solid core, an envelope layer that encloses the solid core, an intermediate layer that encloses the envelope layer, and a cover that encloses the intermediate layer and has a plurality of dimples on a surface thereof. The diameter of the solid core, the center hardness, surface hardness and hardness difference between the center and surface of the solid core, the thickness and surface hardness of the envelope layer, and the thickness and surface hardness of the intermediate layer are each optimized within specific ranges. Moreover, the intermediate layer is formed so as to be harder than the envelope layer and the cover. In addition, the thickness and surface hardness of the cover, and the combined thickness of the envelope layer, intermediate layer and cover are each optimized within specific ranges.

Abstract: The present invention provides a 1,2,4-triazolone derivative represented by Formula (1A) having an antagonistic activity on the arginine-vasopressin 1b receptor or a pharmaceutically acceptable salt thereof and provides a pharmaceutical composition comprising the compound or the salt as an active ingredient, in particular, a therapeutic or preventive agent exhibiting favorable pharmacokinetics in a disease such as mood disorder, anxiety disorder, schizophrenia, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastrointestinal disease, drug addiction, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, head injury, inflammation, immune-related disease, or alopecia.

Abstract: PROBLEM To provide a novel compound, a pharmaceutically acceptable salt or a hydrate thereof useful for preventing or treating for depression, anxiety disorders (such as generalized anxiety disorder, posttraumatic stress disorder, panic disorder, obsessive-compulsive disorder or social anxiety disorder), attention deficit disorder, mania, manic-depressive illness, schizophrenia, mood disorders, stress, sleep disorders, attacks, memory impairment, cognitive impairment, dementia, amnesia, delirium, obesity, eating disorder, appetite disorder, hyperphagia, bulimia, cibophobia, diabetes, cardiovascular diseases, hypertension, dyslipidemia, myocardial infarction, movement disorder (such as Parkinson's disease, epilepsy, convulsion or tremor), drug abuse, drug addiction or sexual dysfunction, based on a melanin-concentrating hormone receptor (MCH receptor) antagonistic action. SOLUTION A compound, a pharmaceutically acceptable salt or a hydrate thereof represented by the formula (I).

Abstract: An electronic device includes a housing including an installing part having an opening, an electronic component installed in the installing part and including a first side surface and a second side surface, an attachment component fastened to the electronic component and configured to fix the first side surface to the housing, and a cover component detachably attached to the opening and configured to cover the opening. The cover component includes an elastic member configured to exert force to the vicinity of the second side surface.

Abstract: Problem To provide a novel compound, a pharmaceutically acceptable salt or a hydrate thereof useful for preventing or treating for depression, anxiety disorders (such as generalized anxiety disorder, posttraumatic stress disorder, panic disorder, obsessive-compulsive disorder or social anxiety disorder), attention deficit disorder, mania, manic-depressive illness, schizophrenia, mood disorders, stress, sleep disorders, attacks, memory impairment, cognitive impairment, dementia, amnesia, delirium, obesity, eating disorder, appetite disorder, hyperphagia, bulimia, cibophobia, diabetes, cardiovascular diseases, hypertension, dyslipidemia, myocardial infarction, movement disorder (such as Parkinson's disease, epilepsy, convulsion or tremor), drug abuse, drug addiction or sexual dysfunction, based on a melanin-concentrating hormone receptor (MCH receptor) antagonistic action. Solution A compound, a pharmaceutically acceptable salt or a hydrate thereof represented by the formula (I).

Abstract: The invention provides a method of manufacturing golf balls composed of a core and one or more cover layer which encloses the core, at least one cover layer being a thin layer having a thickness of 1.0 mm or less. The thin layer is formed to a desired thickness on a surface of a core or spherical body by holding within a mold cavity the core or a spherical body composed of the core enclosed by a cover layer and injecting a synthetic resin material into a space defined by a surface of the core or spherical body and an inner face of the mold cavity so as to form a cover layer on the surface of the core or spherical body, then grinding the resulting cover layer to a thickness of at least 0.1 mm with a specific type of grinder. Golf balls obtained in this way can be provided with a good sphericity even when the cover is formed to a very small thickness.

Abstract: The casing structure includes a first frame having a top surface section; a second frame having a top surface section and a bent section that is bent on the top surface section at a location where the the second frame abuts the first frame; and a hinge mounted over the top surface section of the first frame including the location and the top surface section of the second part. The hinge secures an LCD to the second frame.

Abstract: A multi-piece solid golf ball has a solid core, an envelope layer that encloses the solid core, an intermediate layer that encloses the envelope layer, and a cover that encloses the intermediate layer and has a plurality of dimples on a surface thereof. The diameter of the solid core, the center hardness, surface hardness and hardness difference between the center and surface of the solid core, the thickness and surface hardness of the envelope layer, and the thickness and surface hardness of the intermediate layer are each optimized within specific ranges. Moreover, the intermediate layer is formed so as to be harder than the envelope layer and the cover. In addition, the thickness and surface hardness of the cover, and the combined thickness of the envelope layer, intermediate layer and cover are each optimized within specific ranges.

Abstract: A multi-piece solid golf ball has a solid core, an envelope layer that encloses the solid core, an intermediate layer that encloses the envelope layer, and a cover that encloses the intermediate layer and has a plurality of dimples on a surface thereof. The diameter of the solid core, the center hardness, surface hardness and hardness difference between the center and surface of the solid core, the thickness and surface hardness of the envelope layer, and the thickness and surface hardness of the intermediate layer are each optimized within specific ranges. Moreover, the intermediate layer is formed so as to be harder than the envelope layer and the cover. In addition, the thickness and surface hardness of the cover, and the combined thickness of the envelope layer, intermediate layer and cover are each optimized within specific ranges.

Abstract: The invention provides a method of manufacturing golf balls composed of a core and one or more cover layer which encloses the core, at least one cover layer being a thin layer having a thickness of 1.0 mm or less. The thin layer is formed to a desired thickness on a surface of a core or spherical body by holding within a mold cavity the core or a spherical body composed of the core enclosed by a cover layer and injecting a synthetic resin material into a space defined by a surface of the core or spherical body and an inner face of the mold cavity so as to form a cover layer on the surface of the core or spherical body, then grinding the resulting cover layer to a thickness of at least 0.1 mm with a specific type of grinder. Golf balls obtained in this way can be provided with a good sphericity even when the cover is formed to a very small thickness.

Abstract: A multi-piece solid golf ball has a solid core, an envelope layer that encloses the solid core, an intermediate layer that encloses the envelope layer, and a cover that encloses the intermediate layer and has a plurality of dimples on a surface thereof. The diameter of the solid core, the center hardness, surface hardness and hardness difference between the center and surface of the solid core, the thickness and surface hardness of the envelope layer, and the thickness and surface hardness of the intermediate layer are each optimized within specific ranges. Moreover, the intermediate layer is formed so as to be harder than the envelope layer and the cover. In addition, the thickness and surface hardness of the cover, and the combined thickness of the envelope layer, intermediate layer and cover are each optimized within specific ranges.