Abstract: An object of the present invention is to provide a model mammal for diabetes onset, being useful for elucidating the onset mechanism of diabetes caused by a blockage of signal transduction from insulin, and for the development of a remedy for said diabetes, and to provide a screening method of a remedy for said diabetes. A diabetic-prone transgenic mouse is prepared in a process comprising the steps of: a transgene that contains a Meg1/Grb10 gene, an imprinted gene exhibiting maternal expression, or a human GRB10 gene in the downstream of a chicken ?-actin promoter and in the upstream of a rabbit ?-globin poly A is constructed, and subsequently the transgene is microinjected into a male proneucleus of a mouse fertilized egg; thus obtained egg cell is cultured and then transplanted into an oviduct of a pseudopregnant female mouse; after rearing up the recipient animal, baby mice that have the above-mentioned cDNA are selected from the mice born from the recipient animal.

Abstract: An information processing apparatus includes a hard disk drive, an acceleration sensor, and a determination section. The hard disk drive is capable of moving a head of the hard disk drive to a data-free landing zone. The acceleration sensor detects acceleration. The determination section obtains a low frequency component from the detected acceleration and determines whether it is necessary to move the head of the hard disk drive to the data-free landing zone based on the low frequency component.

Abstract: An information processing apparatus is disclosed. The information processing apparatus includes a hard disk drive, an acceleration sensor, a determination section, and a threshold value setup section. The hard disk drive is capable of retracting a head to a data-free landing zone. The acceleration sensor detects acceleration. The determination section obtains high frequency components from acceleration information detected by the acceleration sensor, obtains a vibration level corresponding to the obtained high frequency components, compares the vibration level with a threshold value which has been set up, and determines whether or not there is a necessity to retract the head of the hard disk drive to the data-free landing zone. The threshold value setup section allows a user to change the threshold value and set up the changed threshold value.

Abstract: An object of the present invention is to provide a model mammal for diabetes onset, being useful for elucidating the onset mechanism of diabetes caused by a blockage of signal transduction from insulin, and for the development of a remedy for said diabetes, and to provide a screening method of a remedy for said diabetes. A diabetic-prone transgenic mouse is prepared in a process comprising the steps of: a transgene that contains a Meg1/Grb10 gene, an imprinted gene exhibiting maternal expression, or a human GRB10 gene in the downstream of a chicken &bgr;-actin promoter and in the upstream of a rabbit &bgr;-globin poly A is constructed, and subsequently the transgene is microinjected into a male proneucleus of a mouse fertilized egg; thus obtained egg cell is cultured and then transplanted into an oviduct of a pseudopregnant female mouse; after rearing up the recipient animal, baby mice that have the above-mentioned cDNA are selected from the mice born from the recipient animal.