Abstract: In an embodiment, an object of the present invention is to provide a double-stranded nucleic acid complex having a novel structure. In an embodiment, the present invention relates to a nucleic acid complex comprising a first nucleic acid strand and a second nucleic acid strand, wherein said first nucleic acid strand: (1) is capable of hybridizing to at least a part of a target transcriptional product; (2) has an antisense effect on the target transcriptional product; and (3) is a gapmer comprising a central region, and a 5? wing region and a 3? wing region, said second nucleic acid strand comprises at least one sugar-unmodified central region (first exposed region) consisting of one sugar-unmodified ribonucleoside or two or three contiguous sugar-unmodified ribonucleosides linked by an internucleoside bond, which is or are complementary to a part of said first nucleic acid strand, and said first nucleic acid strand is annealed to said second nucleic acid strand.

Abstract: The present teaching aims to provide: a cam angle sensor fault diagnosis apparatus for straddled vehicle, capable of detecting a fault of a cam angle sensor installed in a straddled vehicle and guessing a fault place; an engine system; and a straddled vehicle.

Abstract: A control device for a rotating element rotated by a four-stroke engine has a high degree of freedom in the choice of an apparatus to which the control device is applicable. The control device includes a rotation speed acquisition unit configured to obtain a rotation speed of the rotating element rotated by the four-stroke engine, and an undulation detection unit configured to, based on the rotation speed obtained by the rotation speed acquisition unit, detect a periodic undulation contained in a rotation fluctuation of the four-stroke engine, the periodic undulation having an angular period longer than a crank angle corresponding to four strokes.

Abstract: The present teaching aims to provide: a cam angle sensor fault diagnosis apparatus for straddled vehicle, capable of detecting a fault of a cam angle sensor installed in a straddled vehicle and guessing a fault place; an engine system; and a straddled vehicle.

Abstract: A control device for a rotating element rotated by a four-stroke engine has a high degree of freedom in the choice of an apparatus to which the control device is applicable. The control device includes a rotation speed acquisition unit configured to obtain a rotation speed of the rotating element rotated by the four-stroke engine, and an undulation detection unit configured to, based on the rotation speed obtained by the rotation speed acquisition unit, detect a periodic undulation contained in a rotation fluctuation of the four-stroke engine, the periodic undulation having an angular period longer than a crank angle corresponding to four strokes.

Abstract: The present invention of the application provides a method for producing an antibody which comprises inoculating an expression vector expressing a fusion protein to an animal, and isolating and purifying an antibody against an antigenic protein from the animal, wherein the fusion protein is an antigenic protein fused to the C-terminal side of a transmembrane domain in which the N-terminal side is located in the cell and the C-terminal is out of the cell. According to the present invention, an antibody against an antigenic protein, which it was difficult to produce in the so far known gene immunization, can be produced. The resulting an antibody is useful as drugs, diagnostic agents, and reagents for the research.

Abstract: A self-heat generating type honeycomb filter is mounted in an exhaust pipe line of an engine, and a plane plate and a corrugated plate are layered, then wound, and the first slit portion and second slit portion having openings, respectively, are formed between an up-stream and down stream side end portions of the plane and corrugated plates. An electric current is applied between the up-stream and down stream side end portions, to heat the first and second slit portions. Accordingly, a self-heat generation type catalytic converter capable of realizing both high resistance and low thermal capacity, and further ensuring a reduction in thermal conduction, and durability, and raising the temperature up to the sufficient level with less power consumption, can be provided.