Abstract: The present invention provides a therapeutic agent for refractory viral infections, etc., which is capable of reducing or eliminating cccDNA from hepatocytes. The therapeutic agent for refractory viral infections according to the present invention is characterized by comprising a complex encapsulating poly-I or a poly-I analog and poly-C or a poly-C analog within a drug carrier useful for drug delivery into cells, wherein the surface of the carrier is conjugated with a molecule imparting the ability to accumulate in hepatocytes.

Abstract: An inertial sensor includes a dual atom interferometer. A moving standing light wave generation device in the dual atom interferometer generates M (3?M) moving standing light waves. Each of the M moving standing light waves is generated by a pair of counter-propagating laser beams. The moving standing light wave generation device adjusts two-photon detuning of a pair of counter-propagating laser beams corresponding to each of N (2?N<M) moving standing light waves out of the M moving standing light waves such that the difference between an interferometric phase corresponding to one atomic beam obtained by interfering with the M moving standing light waves and an interferometric phase corresponding to the other atomic beam obtained by interfering with the M moving standing light waves stays constant.

Abstract: A valve device includes a housing, a stationary valve and a drive valve. The stationary valve is placed in a fluid passage of the housing. The stationary valve forms a first passage, which conducts fluid, and a penetrating chamber which penetrates through the stationary valve in the axial direction. The drive valve is placed on one axial side of the stationary valve in the fluid passage and forms a second passage which conducts the fluid. The drive valve communicates the second passage to the first passage through rotation of the drive valve. The housing has a bottom portion that covers the penetrating chamber from another axial side. An upstream passage of the fluid passage, which is located on an upstream side of the drive valve and the stationary valve in a flow direction of the fluid, is communicated with the penetrating chamber through a communication passage.

Abstract: A circuit-integrated motor 100 (100A to 100D) includes: a motor 10; a control board 40 for controlling the motor 10; a casing 50 including a partition wall portion 60 made of metal and dividing a board housing chamber 51 for housing the control board 40 from a placement space for the motor 10; a terminal 70 for connecting the control board 40 to an external device; and a terminal holder 80 formed of resin and holding the terminal 70. The terminal holder 80 is molded integrally with the partition wall portion 60 by insert molding with the partition wall portion 60 and the terminal 70 being insert parts.

Abstract: A display controller converts a detection target region contained within a detection range of an obstruction sensor group and extending from a vehicle to the periphery thereof into a virtual marker image and causes a virtual image to be displayed by superimposing the image over a scene in front of the vehicle. When the relative position of an obstruction is within the detection target region, the display controller causes an arc-shaped ripple spreading in a direction based on the relative position of the obstruction to be displayed in a region, of the virtual marker image, located in a direction based on the relative position of the obstruction. The display controller converts the important information into a notification image and causes the notification image to be displayed in a display medium. The display controller changes the display format of at least one of the virtual marker image or the notification image.

Abstract: A detection method includes: obtaining periodically and repeatedly sensor values output from a capacitive sensor; determining whether the sensor values obtained exceed threshold Th1; calculating, as first difference value ?1X of each of target sensor values CX, a difference between target sensor value CX and sensor value CX+1 immediately before the target sensor value; calculating, as second difference value ?2X of each of target sensor values CX, a difference between (i) first difference value ?1X of target sensor value CX and (ii) first difference value ?1X+1 of sensor value CX+1 immediately before target sensor value CX; comparing each of second difference values ?2X calculated and threshold Th2, and selecting one sensor value CRet based on a result of the comparing; and outputting the one sensor value CRet selected.

Abstract: A fuel cell stack including a cell stacked body formed by stacking power generation cells in a predetermined direction, an exhaust gas flow path penetrating the cell stacked body in the predetermined direction so as to discharge a reaction gas supplied to the plurality of power generation cells, and a flow path forming portion forming a drainage flow path so that water flows from an upstream side to a downstream side of the exhaust gas flow path. The flow path forming portion includes a communicating tube disposed in the exhaust gas flow path so as to communicate with the upstream side and the downstream side of the exhaust gas flow path respectively through a first opening and a second opening of the communicating tube, and the flow path forming portion further includes a diaphragm portion at an inlet of the drainage flow path.

Abstract: A fuel cell stack including a cell stacked body, an exhaust gas flow path penetrating the cell stacked body in a predetermined direction so as to discharge a reaction gas supplied to a plurality of power generation cells, and a communicating tube disposed in the exhaust gas flow path so as to communicate with an upstream side and a downstream side of the exhaust gas flow path respectively through a first opening and a second opening of the communicating tube. The exhaust gas flow path includes a reduced diameter portion configured to gradually decrease a flow path area toward an outlet of the exhaust gas flow path, and the second opening communicates with the exhaust gas flow paths between an end on a small diameter side of the reduced diameter portion and the outlet of the exhaust gas flow path.

Abstract: A fuel cell stack including an outside unit disposed outside a cell stacked body and a communicating tube disposed in an exhaust gas flow path to communicate with an upstream and downstream sides of the exhaust gas flow path through a first and second opening. A first and second support portions supporting a first and second end portions on a first and second end sides of the communicating tube are formed in tubular shapes so as to surround the first and second end portions and communicate an internal space of the communicating tube with the exhaust gas flow path. The first and second support portions include tapered portions so that edge portions on outer peripheral surface sides of the first and second end surfaces are capable of abutting on peripheral surfaces of through-holes over a half circumference or longer in a circumferential direction, respectively.

Abstract: A hermetic portion on the side of a main body portion of a gas insulated switchgear and a hermetic portion of a bushing tank which has polymer bushings connected to the main body portion are configured separately, and electrical connection between the main body portion side and the bushing tank is carried out in an open portion. A mid tank is provided in the rear of the main body portion in which a switching apparatus is housed, and conductor portions which are horizontally led out from the main body portion are led into the mid tank, bent upward, and connected to bushings on the top of the mid tank. Cables are extended downward from the bottom of the bushing tank disposed above the mid tank via a support panel, and in the open portion, the cables are connected to the bushings.

Abstract: A suspension for a disk drive includes a plate member having a first surface, a second surface opposite to the first surface, a first penetration portion penetrating the first surface and the second surface, and a second penetration portion spaced from the first penetration portion and penetrating the first surface and the second surface, an actuator provided on the second surface and having an electrode located in the first penetration portion, and a flexure having an electrode connection portion connected to the electrode. The electrode connection portion includes a first region and a second region having a thickness smaller than a thickness of the first region, and the second region overlaps the second penetration portion.

Abstract: This bile acid adsorbing agent composed of silica particles, to which an organosilicon compound represented by general formula (1) is bonded, has the advantage that water-absorption swelling does not occur. (In formula (1), R1, R2, and R3 each independently represent a hydrogen atom, a C1-C20 alkyl group, a vinyl group, a phenyl group, or a benzyl group, and R4 represents a group represented by general formula (2), provided that R1 and R3 may be bonded to each other to form a benzene ring.) (In formula (2), A represents a linear or branched divalent linking group which may contain a heteroatom, a urethane bond, a urea bond, a thiourethane bond, and/or a thiourea bond, R5,s each independently represent a C1-C10 alkyl group or a C6-C10 aryl group, R6,s each independently represent a C1-C10 alkyl group or a C6-C10 aryl group, and n represents an integer of 1-3.

Abstract: A method of welding a first metal plate and a second metal plate that is thicker than the first plate, by a laser beam. The first plate and the second plate are disposed to overlap one another in a thickness direction. In a first laser irradiation step, the laser beam is emitted at the first plate, to form an initial nugget including a front-side nugget portion in the first plate, a back-side nugget portion in the second plate and having a diameter smaller than a diameter of the front-side nugget portion, and an annular flat surface portion existing between the front-side nugget portion and the back-side nugget portion. In a subsequent laser irradiation step, the laser beam is emitted again at the initial nugget after the initial nugget is solidified, thereby increasing the diameter of the back-side nugget portion.

Abstract: A suspension for a disk drive includes a plate member having a first surface, a second surface opposite to the first surface, a first penetration portion penetrating the first surface and the second surface, and a second penetration portion spaced from the first penetration portion and penetrating the first surface and the second surface, an actuator provided on the second surface and having an electrode located in the first penetration portion, and a flexure having an electrode connection portion connected to the electrode. The electrode connection portion includes a first region and a second region having a thickness smaller than a thickness of the first region, and the second region overlaps the second penetration portion.

Abstract: Provided is a backup system including a storage system and a backup server, in which the backup server includes a ledger for managing a copy number and a backup acquisition date and time for each backup image, a data volume that stores data accessed by a business server, a backup image volume that stores a plurality of backup images at different time points of the data volume, an access volume having a volume ID for accessing the backup image from the backup server, and a data protection area including at least one volume having an internal volume ID instead of the volume ID for accessing from the backup server are configured in the storage system, and the backup image stored in the data protection area and the access volume are associated, and the backup image in the data protection area is provided to the backup server.

Abstract: A fuel cell system includes a plurality of fuel cell stacks, and a supply pipeline and a discharge pipeline that are connected to a supply channel and a discharge channel of each of the fuel cell stacks. A fluid sequentially supplied to the plurality of fuel cells in a stacking direction flows through the supply channel. A fluid sequentially discharged from the plurality of fuel cells in the stacking direction flows through the discharge channel A flowing direction of the fluid in the supply channel is a direction from a first end plate toward a second end plate. A flowing direction of the fluid in the discharge channel is a direction from the first end plate toward the second end plate.

Abstract: Provided is an exhaust valve device 1 for a vehicle in which a valve element 7 is supported in an exhaust passage 4 by a rotating shaft 5 axially supported by a valve body 3, a flexible joint member 16 is secured to an output shaft 13a of a motor unit 13 attached to the valve body 3, and a lower end of the flexible joint member 16 and an upper end of the rotating shaft 5 are coupled via a rigid joint member 15, in which the rigid joint member 15 includes: a sealing element 18 having a sealing surface 18a and arm portions 18c, the sealing surface 18a being coupled to one end of the rotating shaft 5 and sealing an axially supported portion of one end of the rotating shaft to prevent exhaust gas from leaking, the arm portions 18c being formed in a periphery of the sealing surface 18a; and a transmission element 19 having a spring groove 19a and engagement grooves 19b, the spring groove 19a being coupled to the end of the flexible joint member 16, the engagement grooves 19b being engaged with the arm portions 18c

Abstract: A light emitting device includes: a light emitting element; a reflection wall that surrounds the light emitting element; and a diffusion reflection sheet that includes a plurality of particles and permits entrance of emitted light from the light emitting element and reflected light from the reflection wall.

Abstract: A butterfly valve device includes: a body that defines a passage through which a fluid flows and a bearing hole arranged on an axis; a shaft that is rotatably passed through the bearing hole, has a two-sided width portion formed in a region facing the passage and a slit hole penetrating a center of the two-sided width portion, and has a columnar outer contour; and a butterfly valve that is fitted into the slit hole and fixed to the shaft to open and close the passage. In a surface region where the two-sided width portion of the shaft and the butterfly valve are close to each other, the butterfly valve device has a step suppressing portion that suppresses a step so as to make the fluid flow streamlined when the butterfly valve is fully opened.

Abstract: A bushing tank having power receiving lead-in bushings of three phases to which conductor portions extended rearward of a main body portion in which a switching device is housed are connected is included, and the power receiving lead-in bushings of the three phases are disposed at an upper surface portion of the bushing tank at equal intervals in a circumferential direction such that end portions thereof are inclined outward so as to be separated from each other, and one of the power receiving lead-in bushings of the three phases is disposed along a front-rear direction of the main body portion. Owing to this configuration, it is possible not only to ensure insulation distances between the end portions of the power receiving lead-in bushings but also to ensure insulation distances between lead-in wires regardless of a power receiving lead-in direction.