Patents by Inventor Naoki Yamanaka

Naoki Yamanaka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11542301
    Abstract: The present application addresses the problem of providing an Fc-binding protein having an improved antibody separation ability. The present application also addresses the problem of providing a high-accuracy antibody separation method using an insoluble carrier having the protein immobilized thereon. The problems can be solved by: an Fc-binding protein in which at least an amino acid substitution at a specific position therein occurs and which has reduced affinity for an antibody; and an antibody separation method including allowing an equilibration buffer solution to pass through a column in which an insoluble carrier having the protein immobilized thereon is filled to equilibrate the column, adding a solution containing an antibody to cause the adsorption of the antibody onto the carrier, and eluting the antibody adsorbed on the carrier using an elution solution.
    Type: Grant
    Filed: February 7, 2018
    Date of Patent: January 3, 2023
    Assignee: TOSOH CORPORATION
    Inventors: Yosuke Terao, Yoshiharu Asaoka, Ryoko Otake, Satoshi Endo, Naoki Yamanaka, Yukie Yamamoto, Seigo Oe
  • Patent number: 11460088
    Abstract: A damper includes: first and second rotating elements rotatable around a rotation center; an elastic element elastically expanding and contracting in response to relative rotation of the first and second rotating elements; and a limiter provided in the first rotating element. The limiter includes a lining plate having a first sliding surface, a first cover plate having a second sliding surface and a first abutting surface, a second cover plate having an outer edge part and an inner edge part, and a biasing member. When a difference in torque between the lining plate and the first cover plate is a predetermined value or more, the first sliding surface slides with the second sliding surface, and the second sliding surface is inclined with respect to the first abutting surface so as to face the second direction as going radially inward in a free state of the first cover plate.
    Type: Grant
    Filed: November 26, 2019
    Date of Patent: October 4, 2022
    Assignee: AISIN CORPORATION
    Inventors: Naoki Tachiuchi, Nobuaki Kurita, Sayo Yamanaka, Mitsuru Natsume, Toru Inagaki, Kento Mizuno, Toru Koyama
  • Patent number: 11427828
    Abstract: The present invention addresses the problem of providing FcRn having improved stability with respect to heat and acids, a method for producing said FcRn, an antibody adsorbent in which said FcRn is used, and an antibody isolation method in which said adsorbent is used. The above problem is solved by substituting an amino acid residue at a specific position in an extracellular region of a human FcRn ? chain and/or a ?2 microglobulin region of a human FcRn ? chain by another specific amino acid.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: August 30, 2022
    Assignee: TOSOH CORPORATION
    Inventors: Yosuke Terao, Naoki Yamanaka, Natsuko Kizu, Satoshi Endo, Seigo Oe
  • Patent number: 11414475
    Abstract: The problem to be addressed by the present invention is to provide improved recombinant Fc?RIIb and Fc?RIIa that do not require refolding and exhibit high productivity and thermal stability, and to provide a method for producing the same. Said problem is solved by improved recombinant Fc?RIIb comprising at least the amino acid residues of the extracellular domain of human Fc?RIIb (No. 43 to No. 215 in UniProt No. P31994), wherein, in said amino acid residues, at least one amino acid substitution has occurred at a position corresponding to No. 82, 94, 98, 104, 105, or 139 in UniProt No. P31994. Said problem is also solved by improved recombinant Fc?RIIa comprising at least the amino acid residues of the extracellular domain of human Fc?RIIa (No. 34 to No. 206 in UniProt No. P12318-1), wherein, in said amino acid residues, at least one amino acid substitution has occurred at a position corresponding to No. 73, 85, 89, 95, 96, or 130 in UniProt No. P12318-1.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: August 16, 2022
    Assignees: TOSOH CORPORATION, SAGAMI CHEMICAL RESEARCH INSTITUTE
    Inventors: Kouta Hatayama, Teruhiko Ide, Hiroyuki Ito, Yosuke Terao, Naoki Yamanaka, Satoshi Endo
  • Publication number: 20220252458
    Abstract: A temperature sensing system senses a temperature in the monitor space. The temperature sensing system includes a first detector, a second detector, and a processing unit. The first detector detects a temperature on a ceiling and outputs first information about the temperature on the ceiling. The second detector detects infrared radiation emitted from a floor and outputs second information about the infrared radiation from the floor. The processing unit calculates, based on at least the first information and the second information, a spatial temperature distribution which includes a component in a height direction with respect to the monitor space between the ceiling and the floor.
    Type: Application
    Filed: February 17, 2020
    Publication date: August 11, 2022
    Applicant: Panasonic Intellectual Property Management Co., Ltd.
    Inventors: Ryota SUDO, Takanori SUGIYAMA, Takaaki HIRAMATSU, Nobuaki SHIMAMOTO, Hiroshi YAMANAKA, Naoki KOBAYASHI
  • Patent number: 11319191
    Abstract: There is disclosed a display device making it possible to call effective attention in a use situation where unbalanced passenger load occurs between left and right lanes of a passenger conveyor. This display device includes a first display unit (7A) positioned on the left and a second display unit (7B) positioned on the right toward the passenger conveyor at a boarding (1), a control device (20) to control the first display unit (7A) and the second display unit (7B), and passenger detection (8A, 8B) to detect passengers stepping on the passenger conveyor. The first display unit (7A) and the second display unit (7B) display images representing information to passengers. The passengers pass between the first display unit (7A) and the second display unit (7B) and step on the passenger conveyor.
    Type: Grant
    Filed: October 29, 2018
    Date of Patent: May 3, 2022
    Assignee: Hitachi, Ltd.
    Inventors: Naoki Yamanaka, Shohei Kanayama
  • Publication number: 20210380374
    Abstract: There is disclosed a display device making it possible to call effective attention in a use situation where unbalanced passenger load occurs between left and right lanes of a passenger conveyor. This display device includes a first display unit (7A) positioned on the left and a second display unit (7B) positioned on the right toward the passenger conveyor at a boarding (1), a control device (20) to control the first display unit (7A) and the second display unit (7B), and passenger detection means (8A, 8B) to detect passengers stepping on the passenger conveyor. The first display unit (7A) and the second display unit (7B) display images representing information to passengers. The passengers pass between the first display unit (7A) and the second display unit (7B) and step on the passenger conveyor.
    Type: Application
    Filed: October 29, 2018
    Publication date: December 9, 2021
    Inventors: Naoki YAMANAKA, Shohei KANAYAMA
  • Publication number: 20210277053
    Abstract: The invention aims to provide an immunoglobulin-binding protein having improved chemical stability, especially stability against alkali. The object can be achieved by improving stability against alkali by substituting an amino acid residue(s) at a particular position(s) in an immunoglobulin-binding domain such as domain C of protein A derived from a bacterium belonging to the genus Staphylococcus, to another/other particular amino acid residue(s).
    Type: Application
    Filed: November 8, 2018
    Publication date: September 9, 2021
    Applicant: TOSOH CORPORATION
    Inventors: Naoki YAMANAKA, Yukie UCHIDA, Yosuke TERAO
  • Patent number: 11097208
    Abstract: A vise for column, for attaching a plug to a column tube of a column for chromatography comprising the column tube and the plug to be attached to one end of the column tube, is provided. The vise comprises a column supporter configured to be able to support a part of the column for chromatography, a main body configured to be connected to the column supporter and extending from the column supporter by a predetermined distance, and a column presser configured to be supported at another end of the main body opposite to one end to which the column supporter is connected, and configured to be movable toward and away from the column supporter, and configured to be able to press the plug against the column tube.
    Type: Grant
    Filed: March 6, 2019
    Date of Patent: August 24, 2021
    Assignee: JNC CORPORATION
    Inventors: Naoki Yamanaka, Masami Todokoro
  • Patent number: 11058970
    Abstract: A vise for column, for attaching a plug to a column tube of a column for chromatography comprising the column tube and the plug to be attached to one end of the column tube, is provided. The vise comprises a column supporter configured to be able to support a part of the column for chromatography, a main body configured to be connected to the column supporter and extending from the column supporter by a predetermined distance, and a column presser configured to be supported at another end of the main body opposite to one end to which the column supporter is connected, and configured to be movable toward and away from the column supporter, and configured to be able to press the plug against the column tube.
    Type: Grant
    Filed: March 6, 2019
    Date of Patent: July 13, 2021
    Assignee: JNC CORPORATION
    Inventors: Naoki Yamanaka, Masami Todokoro
  • Patent number: 10815289
    Abstract: Provided are: an Fc-binding protein having improved stability, particularly to heat and acid; a method for producing the protein; an antibody adsorbent using the protein; and a method for separating the antibodies using the adsorbent. Specifically provided are: an Fc-binding protein having improved stability to heat and acid, achieved by substituting an amino-acid residue in a specific position in the extracellular region of human FcyRIIIa with another specific amino acid; a method for producing the protein; an antibody adsorbent using the protein; and a method for separating the antibodies using the adsorbent.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: October 27, 2020
    Assignee: TOSOH CORPORATION
    Inventors: Yoshiharu Asaoka, Toru Tanaka, Yosuke Terao, Naoki Yamanaka, Natsuko Kizu, Masaru Aoki, Teruhiko Ide
  • Publication number: 20200283779
    Abstract: The present invention addresses the problem of providing FcRn having improved stability with respect to heat and acids, a method for producing said FcRn, an antibody adsorbent in which said FcRn is used, and an antibody isolation method in which said adsorbent is used. The above problem is solved by substituting an amino acid residue at a specific position in an extracellular region of a human FcRn ? chain and/or a ?2 microglobulin region of a human FcRn ? chain by another specific amino acid.
    Type: Application
    Filed: April 13, 2018
    Publication date: September 10, 2020
    Applicant: TOSOH CORPORATION
    Inventors: Yosuke TERAO, Naoki YAMANAKA, Natsuko KIZU, Satoshi ENDO, Seigo OE
  • Publication number: 20200223885
    Abstract: The present application addresses the problem of providing an Fc-binding protein having an improved antibody separation ability. The present application also addresses the problem of providing a high-accuracy antibody separation method using an insoluble carrier having the protein immobilized thereon. The problems can be solved by: an Fc-binding protein in which at least an amino acid substitution at a specific position therein occurs and which has reduced affinity for an antibody; and an antibody separation method including allowing an equilibration buffer solution to pass through a column in which an insoluble carrier having the protein immobilized thereon is filled to equilibrate the column, adding a solution containing an antibody to cause the adsorption of the antibody onto the carrier, and eluting the antibody adsorbed on the carrier using an elution solution.
    Type: Application
    Filed: February 7, 2018
    Publication date: July 16, 2020
    Applicant: TOSOH CORPORATION
    Inventors: Yosuke TERAO, Yoshiharu ASAOKA, Ryoko OTAKE, Satoshi ENDO, Naoki YAMANAKA, Yukie YAMAMOTO, Seigo OE
  • Publication number: 20190374875
    Abstract: A column filling apparatus mainly includes a tank, a stirrer being an agitator, a pump, a resin bottle, first to eleventh pipes, first to fourth valves composed of three-way valves, and fifth and sixth valves composed of two-way valves. A suction port is mounted on a leading end of the fifth pipe, and the suction port is inserted into an inner part from a top opening of the resin bottle. The other end of the fifth pipe is connected to the first valve. The first valve is connected to the first pipe, the second pipe, and the fifth pipe, and connects or disconnects these pipes to or from each other. An end of the first pipe is mounted near a bottom of the tank, and is opened near an inner bottom surface of the tank.
    Type: Application
    Filed: June 6, 2019
    Publication date: December 12, 2019
    Applicant: JNC CORPORATION
    Inventors: Naoki YAMANAKA, Masami TODOKORO
  • Publication number: 20190275445
    Abstract: A vise for column, for attaching a plug to a column tube of a column for chromatography comprising the column tube and the plug to be attached to one end of the column tube, is provided. The vise comprises a column supporter configured to be able to support a part of the column for chromatography, a main body configured to be connected to the column supporter and extending from the column supporter by a predetermined distance, and a column presser configured to be supported at another end of the main body opposite to one end to which the column supporter is connected, and configured to be movable toward and away from the column supporter, and configured to be able to press the plug against the column tube.
    Type: Application
    Filed: March 6, 2019
    Publication date: September 12, 2019
    Applicant: JNC CORPORATION
    Inventors: Naoki YAMANAKA, Masami TODOKORO
  • Publication number: 20190233499
    Abstract: The problem to be addressed by the present invention is to provide improved recombinant Fc?RIIb and Fc?RIIa that do not require refolding and exhibit high productivity and thermal stability, and to provide a method for producing the same. Said problem is solved by improved recombinant Fc?RIIb comprising at least the amino acid residues of the extracellular domain of human Fc?RIIb (No. 43 to No. 215 in UniProt No. P31994), wherein, in said amino acid residues, at least one amino acid substitution has occurred at a position corresponding to No. 82, 94, 98, 104, 105, or 139 in UniProt No. P31994. Said problem is also solved by improved recombinant Fc?RIIa comprising at least the amino acid residues of the extracellular domain of human Fc?RIIa (No. 34 to No. 206 in UniProt No. P12318-1), wherein, in said amino acid residues, at least one amino acid substitution has occurred at a position corresponding to No. 73, 85, 89, 95, 96, or 130 in UniProt No. P12318-1.
    Type: Application
    Filed: September 21, 2017
    Publication date: August 1, 2019
    Applicants: TOSOH CORPORATION, SAGAMI CHEMICAL RESEARCH INSTITUTE
    Inventors: Kouta HATAYAMA, Teruhiko IDE, Hiroyuki ITO, Yosuke TERAO, Naoki YAMANAKA, Satoshi ENDO
  • Publication number: 20190211077
    Abstract: Provided are: an Fc-binding protein having improved stability, particularly to heat and acid; a method for producing the protein; an antibody adsorbent using the protein; and a method for separating the antibodies using the adsorbent. Specifically provided are: an Fc-binding protein having improved stability to heat and acid, achieved by substituting an amino-acid residue in a specific position in the extracellular region of human FcyRIIIa with another specific amino acid; a method for producing the protein; an antibody adsorbent using the protein; and a method for separating the antibodies using the adsorbent.
    Type: Application
    Filed: June 24, 2015
    Publication date: July 11, 2019
    Applicant: TOSOH CORPORATION
    Inventors: Yoshiharu ASAOKA, Toru TANAKA, Yosuke TERAO, Naoki YAMANAKA, Natsuko KIZU, Masaru AOKI, Teruhiko IDE
  • Patent number: 10228380
    Abstract: Described herein are methods of identifying compounds that can modulate the transport of a steroid hormone across a phospholipid membrane. Also described herein are methods of identifying compounds that can affect the transcriptional activity of a steroid hormone nuclear receptor.
    Type: Grant
    Filed: February 22, 2018
    Date of Patent: March 12, 2019
    Assignee: The Regents of the University of California
    Inventors: Naoki Yamanaka, Sachiko Yamanaka, Naoki Okamoto, Riyan Bittar
  • Publication number: 20180372760
    Abstract: Described herein are methods of identifying compounds that can modulate the transport of a steroid hormone across a phospholipid membrane. Also described herein are methods of identifying compounds that can affect the transcriptional activity of a steroid hormone nuclear receptor.
    Type: Application
    Filed: February 22, 2018
    Publication date: December 27, 2018
    Applicant: The Regents of the University of California
    Inventors: Naoki YAMANAKA, Sachiko YAMANAKA, Naoki OKAMOTO, Riyan BITTAR
  • Publication number: 20170218044
    Abstract: Provided are: an Fc-binding protein having improved stability, particularly to heat and acid; a method for producing the protein; an antibody adsorbent using the protein; and a method for separating the antibodies using the adsorbent. Specifically provided are: an Fc-binding protein having improved stability to heat and acid, achieved by substituting an amino-acid residue in a specific position in the extracellular region of human FcyRIIIa with another specific amino acid; a method for producing the protein; an antibody adsorbent using the protein; and a method for separating the antibodies using the adsorbent.
    Type: Application
    Filed: June 24, 2015
    Publication date: August 3, 2017
    Applicant: TOSOH CORPORATION
    Inventors: Yoshiharu ASAOKA, Toru TANAKA, Yosuke TERAO, Naoki YAMANAKA, Natsuko KIZU, Masaru AOKI, Teruhiko IDE