Abstract: It is an object of the present invention to provide a medicament for killing tumor cells, having few side effects. According to the present invention, provided is a medicament for killing tumor cells, comprising: a conjugate of a substance that binds to a target substance on the surface of tumor cells and a cytotoxin; and Talaporfin Sodium, Porfimer Sodium or Verteporfin, wherein Talaporfin Sodium, Porfimer Sodium or Verteporfin is administered 1 to 4 days after administration of the conjugate of a substance that binds to a target substance on the surface of tumor cells and a cytotoxin, and a wavelength effective for activating Talaporfin Sodium, Porfimer Sodium or Verteporfin is irradiated 1 to 4 hours after the administration of Talaporfin Sodium, Porfimer Sodium or Verteporfin.

Abstract: It is an object of the present invention to provide a medicament for killing tumor cells, having few side effects. According to the present invention, provided is a medicament for killing tumor cells, comprising: a conjugate of a substance that binds to a target substance on the surface of tumor cells and a cytotoxin; and a glycosylated chlorin derivative or a pharmaceutically acceptable salt thereof.

Abstract: It is an object of the present invention to provide a compound that has absorption in a near infrared region, has high efficiency of singlet oxygen generation (quantum yield), and also has high tumor toxicity when it is combined with an immunotoxin. According to the present invention, provided is a compound represented by the following formula (1) or a salt thereof: wherein L1 and L2 each independently represent a single bond, —O—, —CO—, an alkylene group containing 1 to 8 carbon atoms, a sugar chain, or a combination thereof; R1 and R2 each independently represent an alkyl group containing 1 to 8 carbon atoms, a carboxylic acid group, an amino group, a hydroxyl group, a thiol group, or a biotin residue; R3, R4, R5, R6, R7 and R8 each independently represent an alkyl group containing 1 to 8 carbon atoms, a phenyl group, a carboxylic acid group, an amino group, a hydroxyl group, a thiol group, or a biotin residue; and M represents Mg, Zn, Fe, P, Si, Cu, Sn, Al, Ti, Mo, or Ni.

Abstract: It is an object of the present invention to provide a medicament for killing tumor cells, having few side effects. According to the present invention, provided is a medicament for killing tumor cells that express a target substance at a low level on the cell surface thereof, said medicament comprising: a conjugate of a substance that binds to a target substance on the surface of tumor cells and a cytotoxin; and a photosensitizing dye.

Abstract: It is an object of the present invention to provide a medicament for killing tumor cells, having few side effects. According to the present invention, provided is a medicament for killing tumor cells, comprising: a conjugate of a substance that binds to a target substance on the surface of tumor cells and a cytotoxin; and Talaporfin Sodium, Porfimer Sodium or Verteporfin.

Abstract: The invention relates to a structure comprising at least two sets of folds which is made from laminated materials, such as paper, board, plastic, metal or any other material that is sufficiently rigid and flexible in order to be structured and folded. Each of the aforementioned sets of folds is formed by one curved fold and another straight fold which are folded in opposite directions. The purpose of the invention is to provide a novel pressing or clamping mechanism and a hinge mechanism which is intended for use in the design of articles such as plates, containers, clamps, articles bearing laminate objects and/or volumes, packaging and lamp shades and for use as a hinge device for articles such as doors and lids or with hinged parts. According to the invention, the structure comprises folds which are made from the central area of the laminate, which forces the outer area of said laminate to form the walls of the structure and, thereby, prevent spillages.

Abstract: Disclosed herein is an assay of a denatured lipoprotein, in which the denatured site of the denatured lipoprotein contained in a vital sample is exposed to the surface of its lipoprotein particle upon the reaction of an antibody, which recognizes the denatured lipoprotein, with the vital sample containing the denatured lipoprotein.