Abstract: The present invention provides a salt of a triazine compound which has an inhibitory action against aldosterone synthase and is useful as a drug, and especially as a drug for preventing or treating primary aldosteronism and the like, a crystal thereof, and a method for producing the same. Specifically, the present invention provides a pharmaceutically acceptable salt of 3-[4-[[trans-4-(acetamino)cyclohexyl]carbamoylmethyl]piperazin-1-yl]-5-(p-tolyl)-1,2,4-triazine, wherein the salt is hydrobromide, sulfate, succinate, or tosilate, and the like.

Abstract: The present invention provides a crystal of 1-{2-[(3S,4R)-1-[(3R,4R)-1-cyclopentyl-3-fluoro-4-(4-methoxyphenyl)pyrrolidine-3-carbonyl]-4-(methoxymethyl)pyrrolidin-3-yl]-5-(trifluoromethyl)phenyl}piperidine-4-carboxylic acid having a certain quality that can be used as a drug substance. Specifically, the present invention provides a crystal comprising an equimolar amount of 1-{2-[(3S,4R)-1-[(3R,4R)-1-cyclopentyl-3-fluoro-4-(4-methoxyphenyl)pyrrolidine-3-carbonyl]-4-(methoxymethyl)pyrrolidin-3-yl]-5-(trifluoromethyl)phenyl}piperidine-4-carboxylic acid and phosphoric acid.

Abstract: The present invention provides novel pharmaceutically acceptable salts of a morpholine derivative, including a malate, a tartrate, a hydrochloride, an acetate, and a naphthalene disulfonate thereof, wherein the tartrate has 3 crystal salt forms: crystal form A, crystal form B and dihydrate; the malate, the hydrochloride, and the acetate each have one crystal salt form; the naphthalene disulfonate is amorphous. When compared to the known morpholine derivative free base, the present invention has one or more improved properties, e.g., a better crystalline state, greatly improved water solubility, light stability and thermal stability, etc. The present invention further provides preparation methods for the salts of morpholine derivative and the crystal forms thereof, pharmaceutical compositions and use thereof.

Abstract: The present invention provides novel pharmaceutically acceptable salts of a morpholine derivative, including a malate, a tartrate, a hydrochloride, an acetate, and a naphthalene disulfonate thereof, wherein the tartrate has 3 crystal salt forms: crystal form A, crystal form B and dihydrate; the malate, the hydrochloride, and the acetate each have one crystal salt form; the naphthalene disulfonate is amorphous. When compared to the known morpholine derivative free base, the present invention has one or more improved properties, e.g., a better crystalline state, greatly improved water solubility, light stability and thermal stability, etc. The present invention further provides preparation methods for the salts of morpholine derivative and the crystal forms thereof, pharmaceutical compositions and use thereof.

Abstract: The present invention provides 3-{(2S,4S)-4-[4-(3-methyl -1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2 -ylcarbonyl}thiazolidine (compound I) useful as a dipeptidyl peptidase-IV inhibitor, which has superior properties of stability and hygroscopicity, and reproducible crystal structure, and a production method thereof.

Abstract: The present invention provides 3-{(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl}thiazolidine (compound I) useful as a dipeptidyl peptidase-IV inhibitor, which has superior properties of stability and hygroscopicity, and reproducible crystal structure, and a production method thereof.

Abstract: The present invention provides 3-{(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl}thiazolidine (compound I) useful as a dipeptidyl peptidase-IV inhibitor, which has superior properties of stability and hygroscopicity, and reproducible crystal structure, and a production method thereof.

Abstract: A job, or the copy, is transmitted to a designated destination. A transmission job or a printing job is stored in conjunction with a corresponding execution time in the job storage unit, so that a job can be selected from the job list and the execution time for the selected job can be changed. Further, the jobs stored in the print queue are displayed as a list, and a selected job is moved from the print queue to the job storage unit. In addition, the histories of jobs that were executed are displayed as a list, so that a specific job can be selected and re-executed. When logout is instructed, management data are examined in order to determine whether there is an unprocessed job that was previously instructed by the user. If an unprocessed job is found, the user is notified. If the operator is a manager, a menu is displayed so that all the jobs in the print queue can be deleted. When jobs are deleted, the owners of the individual jobs are notified.

Abstract: The present invention provides 3-{(2S,4S)-4-[4-(3-methyl-1-phenyl-1H -pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl}thiazolidine (compound I) useful as a dipeptidyl peptidase-IV inhibitor, which has superior properties of stability and hygroscopicity, and reproducible crystal structure, and a production method thereof.

Abstract: A compound represented by the following formula (I), a pharmacologically acceptable salt thereof or a hydrate thereof or a solvate thereof, which shows not only a C5a receptor antagonistic activity but also high activity in the biological availability, as compared to its racemate.

Abstract: A compound of the formula (I) or a pharmaceutically acceptable salt thereof, a hydrate thereof, a solvate thereof, an optically active compound thereof, a racemate thereof or a diastereomer mixture thereof has a superior tyrosine-specific protein kinase inhibitory activity and is useful as a pharmaceutical agent, particularly as an agent for the prophylaxis or treatment of various cancers, psoriasis or diseases caused by arteriosclerosis, and the like.

Abstract: A compound of the formula (I) or a pharmaceutically acceptable salt thereof, a hydrate thereof, a solvate thereof, an optically active compound thereof, a racemate thereof or a diastereomer mixture thereof has a superior tyrosine-specific protein kinase inhibitory activity and is useful as a pharmaceutical agent, particularly as an agent for the prophylaxis or treatment of various cancers, psoriasis or diseases caused by arteriosclerosis, and the like.

Abstract: A job is selected from a job list, and is either copied or is extracted from a job storage unit. The job, or the copy, is transmitted to a designated destination. A transmission job or a printing job is stored in conjunction with a corresponding execution time in the job storage unit, so that a job can be selected from the job list and the execution time for the selected job can be changed. Further, the jobs stored in the print queue are displayed as a list, and a selected job is moved from the print queue to the job storage unit, so that the printing of the job in the print queue can be performed. In addition, the histories of jobs that were executed are displayed as a list, so that a specific job can be selected and re-executed. Furthermore, a process that is performed is managed for the user who instructed the process. When logout is instructed, management data are examined in order to determine whether there is an unprocessed job that was previously instructed by the user.

Abstract: A job is selected from a job list, and is either copied or is extracted from a job storage unit. The job, or the copy, is transmitted to a designated destination. A transmission job or a printing job is stored in conjunction with a corresponding execution time in the job storage unit, so that a job can be selected from the job list and the execution time for the selected job can be changed. Further, the jobs stored in the print queue are displayed as a list, and a selected job is moved from the print queue to the job storage unit, so that the printing of the job in the print queue can be performed. In addition, the histories of jobs that were executed are displayed as a list, so that a specific job can be selected and re-executed. Furthermore, a process that is performed is managed for the user who instructed the process. When logout is instructed, management data are examined in order to determine whether there is an unprocessed job that was previously instructed by the user.

Abstract: An attribute of object information to be processed and a corresponding process are designated, and a command to be executed is set. When the process designated for the object information having the designated attribute is performed, the command that is set is executed. Further, a status that is employed as a process execution condition is designated, and a corresponding process that is to be performed while the status corresponds to that of the designated status is stored with that status. Then, when it is determined that the current status is the designated status, the corresponding process is performed, and thus, each time a specific event occurs, a corresponding process can be performed without an instruction having to be issued. Specifically, a trigger for the issuance of a notification is set, and a time period extending from the time the trigger is tripped until the notification is issued is designated.

Abstract: A job is selected from a job list, and is either copied or is extracted from a job storage unit. The job, or the copy, is transmitted to a designated destination. A transmission job or a printing job is stored in conjunction with a corresponding execution time in the job storage unit, so that a job can be selected from the job list and the execution time for the selected job can be changed. Further, the jobs stored in the print queue are displayed as a list, and a selected job is moved from the print queue to the job storage unit, so that the printing of the job in the print queue can be performed. In addition, the histories of jobs that were executed are displayed as a list, so that a specific job can be selected and re-executed. Furthermore, a process that is performed is managed for the user who instructed the process. When logout is instructed, management data are examined in order to determine whether there is an unprocessed job that was previously instructed by the user.

Abstract: A compound of the formula (I) 1

Abstract: A job is selected from a job list, and is either copied or is extracted from a job storage unit. The job, or the copy, is transmitted to a designated destination. A transmission job or a printing job is stored in conjunction with a corresponding execution time in the job storage unit, so that a job can be selected from the job list and the execution time for the selected job can be changed. Further, the jobs stored in the print queue are displayed as a list, and a selected job is moved from the print queue to the job storage unit, so that the printing of the job in the print queue can be performed. In addition, the histories of jobs that were executed are displayed as a list, so that a specific job can be selected and re-executed. Furthermore, a process that is performed is managed for the user who instructed the process. When logout is instructed, management data are examined in order to determine whether there is an unprocessed job that was previously instructed by the user.

Abstract: A phosphonate nucleotide compound represented by formula (I): (wherein R1 is a C1-C6 alkyl group or the like, R2 is a hydrogen atom, a C1-C4 alkyl group substituted by one or more halogen atoms or the like, R3 is a hydrogen atom, a C1-C4 alkyl group substituted by one or more halogen atoms or the like, R4 is a hydrogen atom, a C1-C4 alkyl group substituted by one or more halogen atoms and X is a carbon atom or a nitrogen atom), a salt thereof, a hydrate thereof or a solvate thereof, as well as a medicament containing the same. It is useful as an antiviral agent for human immunodeficiency virus, herpes simplex virus, hepatitis B virus or the like and as an antitumor agent.

Abstract: A phosphonate nucleotide compound having antiviral activity and is useful for an orally available and highly safe antiviral agent, which is represented by the following formula (I): ##STR1## wherein R.sup.1 represents hydrogen, a C.sub.1 -C.sub.6 alkoxy, a halogen-substituted C.sub.1 -C.sub.4 alkoxy, halogen, amino, or nitro; R.sup.2 and R.sup.3 independently represent hydrogen, a C.sub.1 -C.sub.22 alkyl, an acyloxymethy, an acylthioethyl, or a halogen-substituted ethyl; R.sup.4 represents hydrogen, a C.sub.1 -C.sub.4 alkyl, a C.sub.1 -C.sub.4 hydroxyalkyl, or a halogen-substituted C.sub.1 -C.sub.4 alkyl; and X represents carbon or nitrogen.