Abstract: Provided herein are non-naturally occurring, broadly reactive, pan-epitopic antigens derived from Dengue virus that are immunogenic and elicit a broadly reactive immune response, such as a broadly reactive neutralizing antibody response, against Dengue virus subtypes following introduction into a subject. Also provided are non-naturally, broadly reactive occurring immunogens, immunogenic compositions, vaccines, subviral particles (SVPs), and virus-like particles (VLPs) comprising Dengue virus proteins or encoding polynucleotides. Methods of generating an immune response in a subject by administering the immunogens, vaccines, SVPs, VLPs, or immunogenic compositions thereof are provided. In particular, the immunogens comprise a Dengue virus protein, or an antibody binding portion thereof.

Abstract: Provided herein are non-naturally occurring, broadly reactive, pan-epitopic antigens derived from Dengue virus that are immunogenic and elicit a broadly reactive immune response, such as a broadly reactive neutralizing antibody response, against Dengue virus subtypes following introduction into a subject. Also provided are non-naturally, broadly reactive occurring immunogens, immunogenic compositions, vaccines, subviral particles (SVPs), and virus-like particles (VLPs) comprising Dengue virus proteins or encoding polynucleotides. Methods of generating an immune response in a subject by administering the immunogens, vaccines, SVPs, VLPs, or immunogenic compositions thereof are provided. In particular, the immunogens comprise a Dengue virus protein, or an antibody binding portion thereof.

Abstract: The present invention provides a liquid crystal projector including a plurality of liquid crystal panels, a prism for compositing the modulated plural color lights to generate a color image, top and bottom metal plates disposed above and below the prism, and an optical system for magnifying and projecting the generated color image, wherein the liquid crystal panels are directly adhered to metal hold plates, and the metal hold plates are fixed to the top and bottom metal plates such that the emergent surfaces of the liquid crystal panels face the incident surfaces of the prism. Further, a closed space is provided between the incident surfaces of the prism and the emergent surfaces of the liquid crystal panels so as to prevent air contaminants from effecting the performance of the device.

Abstract: The present invention provides a liquid crystal projector including a plurality of liquid crystal panels (1) for modulating a plurality of color lights respectively, a prism (2) for compositing thus modulated plural color lights to generate a color image, and an optical system for magnifying and projecting thus generated color image, wherein the liquid crystal panels (1) are directly adhered to metal hold plates (3), and the metal hold plates (3) are fixed to the prism (2) such that the emergent surfaces of the liquid crystal panels (1) face the incident surfaces of the prism (2). The liquid crystal panels (1) have glass sheets (7) having thermal conductivity fixed to the incident surfaces thereof. Radiation fins (8) are fixed to the prism (2) with the metal hold plates (3) and the glass sheets (7) having thermal conductivity brought into contact with the fins (8).