Patents by Inventor Naomi Ledene Sayre

Naomi Ledene Sayre has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CONNEXIN (Cx)43 HEMICHANNEL-BINDING ANTIBODIES AND USES THEREOF
    Publication number: 20240254212
    Abstract: Antibodies that bind to connexin 43 hemichannels and inhibit, or activate, channel opening are provided. In certain aspects, methods for detecting or treating cancers with antibodies that activate Cx43 channel opening are also provided. Likewise, methods for treating inflammatory diseases (e.g., osteoarthritis) and neurological injuries (e.g., spinal cord injury) with antibodies that inhibit Cx43 channel opening are provided.
    Type: Application
    Filed: February 9, 2024
    Publication date: August 1, 2024
    Inventors: JEAN X. JIANG, ZHIQIANG AN, NINGYAN ZHANG, WEI XIONG, MANUEL A. RIQUELME, SUMIN GU, NAOMI LEDENE SAYRE
  • Methods of treating metastasis, including inhibiting bone cancer metastasis, by administering an antibody which binds connexin 43 (Cx43) hemichannel
    Patent number: 11912758
    Abstract: Antibodies that bind to connexin 43 hemichannels and inhibit, or activate, channel opening are provided. In certain aspects, methods for detecting or treating cancers with antibodies that activate Cx43 channel opening are also provided. Likewise, methods for treating inflammatory diseases (e.g., osteoarthritis) and neurological injuries (e.g., spinal cord injury) with antibodies that inhibit Cx43 channel opening are provided.
    Type: Grant
    Filed: January 11, 2021
    Date of Patent: February 27, 2024
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Jean X. Jiang, Zhiqiang An, Ningyan Zhang, Wei Xiong, Manuel A. Riquelme, Sumin Gu, Naomi Ledene Sayre
  • CONNEXIN (CX) 43 HEMICHANNEL-BINDING ANTIBODIES AND USES THEREOF
    Publication number: 20210253680
    Abstract: Antibodies that bind to connexin 43 hemichannels and inhibit, or activate, channel opening are provided. In certain aspects, methods for detecting or treating cancers with antibodies that activate Cx43 channel opening are also provided. Likewise, methods for treating inflammatory diseases (e.g., osteoarthritis) and neurological injuries (e.g., spinal cord injury) with antibodies that inhibit Cx43 channel opening arc provided.
    Type: Application
    Filed: January 11, 2021
    Publication date: August 19, 2021
    Inventors: Jean X. Jiang, Zhiqiang An, Ningyan Zhang, Wei Xiong, Manuel A. Riquelme, Sumin Gu, Naomi Ledene Sayre
  • Methods of treating an osteolytic tumor and spinal cord injury by administering connexin (Cx) 43 hemichannel-binding antibodies
    Patent number: 10889637
    Abstract: Antibodies that bind to connexin 43 hemichannels and inhibit, or activate, channel opening are provided. In certain aspects, methods for detecting or treating cancers with antibodies that activate Cx43 channel opening are also provided. Likewise, methods for treating inflammatory diseases (e.g., osteoarthritis) and neurological injuries (e.g., spinal cord injury) with antibodies that inhibit Cx43 channel opening are provided.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: January 12, 2021
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Jean X. Jiang, Zhiqiang An, Ningyan Zhang, Wei Xiong, Manuel A. Riquelme, Sumin Gu, Naomi Ledene Sayre
  • CONNEXIN (CX) 43 HEMICHANNEL-BINDING ANTIBODIES AND USES THEREOF
    Publication number: 20190359696
    Abstract: Antibodies that bind to connexin 43 hemichannels and inhibit, or activate, channel opening are provided. In certain aspects, methods for detecting or treating cancers with antibodies that activate Cx43 channel opening are also provided. Likewise, methods for treating inflammatory diseases (e.g., osteoarthritis) and neurological injuries (e.g., spinal cord injury) with antibodies that inhibit Cx43 channel opening are provided.
    Type: Application
    Filed: February 27, 2017
    Publication date: November 28, 2019
    Inventors: Jean X. Jiang, Zhiqiang An, Ningyan Zhang, Wei Xiong, Manuel A. Riquelme, Sumin Gu, Naomi Ledene Sayre