Abstract: Provided herein are systems and methods for identifying alternative splicing derived cell surface antigens. Also provided are methods and compositions for using the identified cell surface antigens. Further provided are methods, compositions, and systems for diagnosing diseases in a subject using the identified cell surface antigens or treating diseases using the same.

Abstract: Disclosed herein are systems and methods for identifying candidate targets that may be used for therapeutic developments. The systems and methods may comprise receiving and analyzing biologically relevant data to identify information or events such as splicing events that may be statistically significant or specific to certain diseases, illnesses or conditions. Also provided are systems and methods for modulating the statistically significant events using compositions or molecules including small molecule compounds, oligonucleotides, proteins or cells.