Patents by Inventor Naoomi Tominaga

Naoomi Tominaga has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR SUPPRESSING BRAIN METASTASIS
    Publication number: 20200216912
    Abstract: A method for suppressing brain metastasis includes administering an miR-181c expression inhibitor, an miR-181c activity inhibitor, or an exosome secretion inhibitor as an active ingredient.
    Type: Application
    Filed: January 17, 2020
    Publication date: July 9, 2020
    Inventors: Takahiro OCHIYA, Naoomi TOMINAGA
  • Method for diagnosing and treating cancer brain metastasis and drug delivery system for enabling passage through blood-brain barrier
    Patent number: 10544466
    Abstract: A method increases permeability of a blood-brain barrier in a subject. The method includes administering a small interfering ribonucleic acid (siRNA) against the 3-Phosphoinositide Dependent Protein Kinase 1 (PDPK1) gene or micro ribonucleic acid (miRNA) miR-181c as an active ingredient to the subject. The method can be applied for delivering a desired active agent to the subject.
    Type: Grant
    Filed: February 24, 2015
    Date of Patent: January 28, 2020
    Assignees: Gene Techno Science Co., Ltd., National Cancer Center, Theoria Science Inc.
    Inventors: Takahiro Ochiya, Naoomi Tominaga
  • METHOD FOR DIAGNOSING, PREVENTING AND TREATING CANCER BRAIN METASTASIS, AND DRUG DELIVERY SYSTEM FOR ENABLING PASSAGE THROUGH BLOOD-BRAIN BARRIER
    Publication number: 20180274035
    Abstract: A purpose of the present invention is to provide a diagnosis and risk evaluation method for cancer brain metastasis and a treatment and prevention method therefor by clarifying the mechanism of blood-brain barrier (BBB) disruption in brain metastasis. Another purpose of the present invention is to provide a drug delivery system to the brain. Still another purpose of the present invention is to provide a medicine, composition and kit to be used in these methods. Therefore, the present invention relates to a method for diagnosing brain metastasis or evaluating the risk of the occurrence of brain metastasis. The method includes the step of determining miR-181c level in a specimen. Further, the present invention relates to a method for treating or preventing brain metastasis. The method includes the step of inhibiting the expression or activity of miR-181c in a cancer patient.
    Type: Application
    Filed: February 24, 2015
    Publication date: September 27, 2018
    Inventors: Takahiro Ochiya, Naoomi Tominaga