Abstract: The present invention provides a composition and a kit for treating tumors, which permits a sulfonamide-containing heterocyclic compound to exhibit its angiogenesis inhibitory activity and antitumor activity more effectively. According to the present invention, the sulfonamide-containing heterocyclic compound can be used in treating cancers more effectively by combination with a VEGF inhibitor/FGF inhibitor.

Abstract: A 2-iminopyrrolidine derivative represented by the formula: {wherein ring B represents a benzene ring, pyridine ring, etc.; R101-R103 represent hydrogen, halogen, C1-6 alkyl, etc.; R5 represents hydrogen, C1-6 alkyl, C1-6 alkoxy-C1-6 alkyl, etc.; R6 represents hydrogen, C1-6 alkyl, C1-6 alkyloxycarbonyl, etc.; Y1 represents a single bond, —CH2—, etc.; Y2 represents a single bond, —CO—, etc.; and Ar represents hydrogen, a group represented by the formula: [wherein R10—R14 represent hydrogen, C1-6 alkyl, hydroxyl, C1-6 alkoxy, etc.; and R11 and R12 or R12 and R13 may bond together to form a 5- to 8-membered heterocyclic ring], etc.}, or a salt thereof.

Abstract: A 2-iminoimidazole derivative represented by the formula: {wherein R1, R2 and R3 represent hydrogen, optionally substituted C1-6 alkyl, etc.; R6 represents hydrogen, C1-6 alkyl, C1-6 alkyloxycarbonyl, etc.; Y1 represents a single bond, —CH2—, etc.; Y2 represents a single bond, —CO—, etc.; and Ar represents hydrogen, a group represented by the formula: [wherein R10-R14 represent hydrogen, C1-6 alkyl, hydroxyl, C1-6 alkoxy, etc., and R11 and R12 or R12 and R13 may bond together to form a 5- to 8-membered heterocycle], etc.} or salt thereof.

Abstract: A cyclic amidine derivative represented by the formula: 1

Abstract: A 2-iminoimidazole derivative represented by the formula: 1

Abstract: A method for testing influence of a drug on integrin expression, which comprises the step of measuring an integrin expression amount in platelets of a patient to which the drug is administered and the step of determining influence of the drug on integrin expression in cells other than platelets based on the measured expression amount.

Abstract: A cold-gas-blow-cooling type machining apparatus including a relative movement device which moves a workpiece and a machining tool relative to each other, and a cold-gas-blow supply device which supplies a cold gas blow to a machining point at which the workpiece is machined by the machining tool. The machining apparatus includes: a workpiece-temperature detecting device which detects a temperature of the workpiece; and a machining-condition control device which controls at least one of the relative movement device and the cold-gas-blow supply device, on the basis of the detected temperature of the workpiece. The machining-condition control device includes a cooling-condition control device which controls the cold-gas-blow supply device so as to control at least one of a temperature and a flow rate of the cold gas blow.

Abstract: The present invention provides: a fuel tank made of a ferritic stainless steel sheet having long lasting corrosion resistance under the environment of the fuel tank and excellent in formability when fabricating the fuel tank; more specifically, a fuel tank made of a ferritic stainless steel sheet containing 10 to 25 mass % of Cr and having an average r-value of 1.9 or larger, an r-value in-plane anisotropy &Dgr;r of 1.0 or smaller, and a total elongation of 30% or larger, having a plane intensity ratio I(111)/I(100) of 10 or larger, and having lubricant films on the surfaces of the steel sheet and a surface friction coefficient of 0.10 or less.

Abstract: The present invention provides a fuel tank or a fuel pipe excellent particularly in the corrosion resistance of the outer surface in a salt damage environment, and is a fuel tank or a fuel pipe excellent in corrosion resistance characterized by: being formed by using a steel sheet or a steel pipe containing Cr of 9.0 to 25.0 mass % as the base material; on the outer surface thereof, having any one or more of welded portions, brazed portions and structurally gapped portions contacting components; and having one or more of metals, whose electrode potential in a 5%-NaCl aqueous solution at 30° C. is −0.4 V or less relative to a saturated calomel electrode, attached to at least a part or parts of said portion(s) of the outer surface in an electrically conductive manner.

Abstract: The present invention provides: a fuel tank made of a ferritic stainless steel sheet having long lasting corrosion resistance under the environment of the fuel tank and excellent in formability when fabricating the fuel tank; more specifically, a fuel tank made of a ferritic stainless steel sheet containing 10 to 25 mass % of Cr and having an average r-value of 1.9 or larger, an r-value in-plane anisotropy &Dgr;r of 1.0 or smaller, and a total elongation of 30% or larger, having a plane intensity ratio I(111)/I(100) of 10 or larger, and having lubricant films on the surfaces of the steel sheet and a surface friction coefficient of 0.10 or less.

Abstract: A cold-gas-blow-cooling type machining apparatus in which a cold gas blow is provided to cool a machining tool and a workpiece while the workpiece is machined by the machining tool. The machining apparatus includes: a rectifying device which rectifies the machining tool; a workpiece-temperature detecting device which detects a temperature of the workpiece; and a rectifying-device control device which controls an operation of the rectifying device on the basis of the temperature of the workpiece which is detected by the workpiece-temperature detecting device.

Abstract: A helmet includes a shock absorbing liner fitted on an inner side of a shell, and a layer of an elastic body for absorbing shock having a component directed along an outer surface of the shell provided between the shell and the shock absorbing liner or between an outer layer of the shock absorbing liner and an inner layer of the shock absorbing liner.

Abstract: In a device cover fastened to a casing of a vibration generating source to cover a device mounted on an outer surface of the casing, an elastic member having a natural frequency different from that of the device cover, is mounted in a mounting bore provided in the device cover which is fastened directly to the casing to close the mounting bore. Thus, the strength and durability requirements of the device cover are satisfied and moreover, the vibration of the device cover can be inhibited to reduce the resonance sound from the device cover in a simple arrangement.