Abstract: Provided herein are compounds of formula (I): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein X1, X2, Ry, Rz, R1, R2, R3, and R4 are as defined herein. Also provided herein is a pharmaceutically acceptable composition comprising a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided herein are methods of using a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, to treat various diseases, disorders, and conditions responsive to the modulation of the contractility of the skeletal sarcomere.

Abstract: A layered bonding material 10 includes a base material 11, a first solder section 12a stacked on a first surface of the base material 11, and a second solder section 12b stacked on a second surface of the base material 11. A coefficient of linear expansion of the base material 11 is 5.5 to 15.5 ppm/K, the first solder section 12a and the second solder section 12b are made of lead-free solder, and both of a thickness of the first solder section 12a and a thickness of the second solder section 12b are 0.05 to 1.0 mm.

Abstract: A transmitter and receiver circuit includes a phase interpolator that generates a process clock having a phase based on a reference clock, a first selector that selects a first clock so that the first clock is the process clock in a first mode and is the reference clock in a second mode, a deserializer that converts a serial input data into a parallel output data in accordance with the first clock and outputs the parallel output data, a second selector that selects a second clock so that the second clock is the reference clock in the first mode and is the process clock in the second mode, and a serializer that converts a second parallel input data into a serial output data according to the second clock and outputs the serial output data.

Abstract: An object of the invention is to provide a simple and easy method for detecting pancreatic cancer having high sensitivity and specificity or risk of the pancreatic cancer. The present invention provides a method of detecting pancreatic cancer including a step of measuring, in a sample derived from a subject, at least one miRNA selected from the following (i) and (ii): (i) an miRNA having a sequence represented by any of SEQ ID NO: 1 to 120; and (ii) an miRNA that hybridizes, under stringent conditions, with a nucleic acid having a sequence complementary to the miRNA (i) and having from 17 to 30 bases.

Abstract: Provided are a micro RNA which can be used as a colon cancer marker, a method for testing for colon cancer which uses the micro RNA which can be used as a colon cancer marker, and a test kit which can be used for the testing method. The colon cancer marker includes micro RNA molecules which are represented by any of the sequences 1 through 25. The method for testing for colon cancer in a subject involves preparing a sample, which contains a micro RNA molecule derived from the subject's colon tissue or colon cell, and detecting a micro RNA molecule represented by any of the sequences 1 through 25 present in the obtained sample.

Abstract: To provide a novel method for arranging a vibration suppressing plate to be arranged in an arm of a magnetic disc actuator, a method for arranging a vibration suppressing plate 3 to an arm 2, projected from a magnetic disc actuator 1, for retaining a magnetic head 63 on a tip end side, includes the following steps of: peeling a first one 5 of peelable members 5 and 6 from a planar adhesive member 7 provided on both surfaces of a both-sided adhesive member 4 with the peelable members 5 and 6, the both-sided adhesive member 4 having the same shape as a predetermined shape of the vibration suppressing plate 3; subsequently, applying, aligning and attaching to the vibration suppressing member 3 the planar adhesive member 7 from which the first peelable member 5 has been peeled and removed; subsequently, peeling the other peeling member 6 to form the vibration suppressing plate 3 having one surface attached to the both-sided adhesive member 4; and subsequently, aligning and attaching the vibration suppressing plat