Patents by Inventor Naoto Yoshinaga

Naoto Yoshinaga has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220296632
    Abstract: The present invention provides a functionalized mRNA including mRNA and double-stranded RNA including at least one RNA oligomer hybridized with mRNA. Functionalized mRNA is provided according to this configuration.
    Type: Application
    Filed: May 16, 2022
    Publication date: September 22, 2022
    Applicants: THE UNIVERSITY OF TOKYO, KAWASAKI INSTITUTE OF INDUSTRIAL PROMOTION
    Inventors: Satoshi UCHIDA, Keiji ITAKA, Kazunori KATAOKA, Naoto YOSHINAGA
  • Patent number: 11364259
    Abstract: The present invention provides a functionalized mRNA including mRNA and double-stranded RNA including at least one RNA oligomer hybridized with mRNA. Functionalized mRNA is provided according to this configuration.
    Type: Grant
    Filed: December 27, 2017
    Date of Patent: June 21, 2022
    Assignees: THE UNIVERSITY OF TOKYO, KAWASAKI INSTITUTE OF INDUSTRIAL PROMOTION
    Inventors: Satoshi Uchida, Keiji Itaka, Kazunori Kataoka, Naoto Yoshinaga
  • Publication number: 20210187005
    Abstract: A pharmaceutical composition includes polymer units ? and ?, each having a hydrophilic polymer chain bound to a cationic polymer chain, and a drug. The polymer units ? and ? are radially arranged such that the cationic polymer chains are directed inward and the hydrophilic polymer chains are directed outward, thereby forming a micelle with the drug encapsulated in the micelle. The cationic polymer chain of the polymer unit ? has a phenylboronic acid group in a side chain, and the cationic polymer chain of the polymer unit ? has a phenylboronic acid binding site in a side chain. The phenylboronic acid group and the phenylboronic acid binding site form a cross-linked structure that can dissociate in an acidic environment and/or in the presence of a substance capable of competitive binding.
    Type: Application
    Filed: February 16, 2021
    Publication date: June 24, 2021
    Applicant: KAWASAKI INSTITUTE OF INDUSTRIAL PROMOTION
    Inventors: Kazunori KATAOKA, Takehiko ISHII, Mitsuru NAITO, Naoto YOSHINAGA, Taisuke ENDO
  • Patent number: 10993960
    Abstract: A pharmaceutical composition includes polymer units ? and ?, each having a hydrophilic polymer chain bound to a cationic polymer chain, and a drug. The polymer units ? and ? are radially arranged such that the cationic polymer chains are directed inward and the hydrophilic polymer chains are directed outward, thereby forming a micelle with the drug encapsulated in the micelle. The cationic polymer chain of the polymer unit ? has a phenylboronic acid group in a side chain, and the cationic polymer chain of the polymer unit ? has a phenylboronic acid binding site in a side chain. The phenylboronic acid group and the phenylboronic acid binding site form a cross-linked structure that can dissociate in an acidic environment and/or in the presence of a substance capable of competitive binding.
    Type: Grant
    Filed: May 8, 2015
    Date of Patent: May 4, 2021
    Assignee: KAWASAKI INSTITUTE OF INDUSTRIAL PROMOTION
    Inventors: Kazunori Kataoka, Takehiko Ishii, Mitsuru Naito, Naoto Yoshinaga, Taisuke Endo
  • Publication number: 20200347385
    Abstract: A complex of mRNA encoding a target gene with RNA oligomers, wherein the RNA oligomers are at least two kinds of RNA oligomers comprising RNA sequences of (a) or (b), the at least two kinds of RNA oligomers are hybridizable respectively with sequences, said sequences being different from each other, in the mRNA sequence, and the complex is formed when a first sequence of the RNA oligomers hybridizes with different mRNA from the second sequence of the RNA oligomers: (a) an RNA sequence which comprises a first sequence consisting of 12-40 bases and being complementary to the mRNA sequence, a linker sequence consisting of 0-100 bases and a sequence which is the same as the first sequence, in this order; and (b) an RNA sequence which comprises a first sequence, which has a 90% or more identity with a sequence consisting of 12-40 bases and being complementary to the mRNA sequence and is hybridizable with mRNA, a linker sequence consisting of 0-100 bases and a second sequence which is the same as the first sequence
    Type: Application
    Filed: November 8, 2018
    Publication date: November 5, 2020
    Applicants: THE UNIVERSITY OF TOKYO, KAWASAKI INSTITUTE OF INDUSTRIAL PROMOTION
    Inventors: Satoshi UCHIDA, Naoto YOSHINAGA, Eol CHO, Kyoko KOJI
  • Publication number: 20190328769
    Abstract: The present invention provides a functionalized mRNA including mRNA and double-stranded RNA including at least one RNA oligomer hybridized with mRNA. Functionalized mRNA is provided according to this configuration.
    Type: Application
    Filed: December 27, 2017
    Publication date: October 31, 2019
    Applicants: THE UNIVERSITY OF TOKYO, KAWASAKI INSTITUTE OF INDUSTRIAL PROMOTION
    Inventors: Satoshi UCHIDA, Keiji ITAKA, Kazunori KATAOKA, Naoto YOSHINAGA
  • Patent number: 8658120
    Abstract: Disclosed is a non-thermofusible phenol resin powder having an average particle diameter of not more than 20 ?m and a single particle ratio of not less than 0.7. This non-thermofusible phenol resin powder preferably has a chlorine content of not more than 500 ppm. This non-thermofusible phenol resin powder is useful as an organic filler for sealing materials for semiconductors and adhesives for semiconductors. The non-thermofusible phenol resin powder is also useful as a precursor of functional carbon materials such as a molecular sieve carbon and a carbon electrode material.
    Type: Grant
    Filed: February 2, 2012
    Date of Patent: February 25, 2014
    Assignee: Air Water Inc.
    Inventors: Naoto Yoshinaga, Satoshi Ibaraki, Yoshinobu Kodani, Takaomi Ikeda
  • Patent number: 8411415
    Abstract: Disclosed is a non-thermofusible phenol resin powder having an average particle diameter of not more than 20 ?m and a single particle ratio of not less than 0.7. This non-thermofusible phenol resin powder preferably has a chlorine content of not more than 500 ppm. This non-thermofusible phenol resin powder is useful as an organic filler for sealing materials for semiconductors and adhesives for semiconductors. The non-thermofusible phenol resin powder is also useful as a precursor of functional carbon materials such as a molecular sieve carbon and a carbon electrode material.
    Type: Grant
    Filed: March 14, 2012
    Date of Patent: April 2, 2013
    Assignee: Air Water Inc.
    Inventors: Naoto Yoshinaga, Yoshiharu Wakayama, Satoshi Ibaraki, Jun Shimormura, Yoshimi Murage, Niro Shiomi, Yoshinobu Kodani, Takaomi Ikeda
  • Patent number: 8409756
    Abstract: Disclosed is a non-thermofusible phenol resin powder having an average particle diameter of not more than 20 ?m and a single particle ratio of not less than 0.7. This non-thermofusible phenol resin powder preferably has a chlorine content of not more than 500 ppm. This non-thermofusible phenol resin powder is useful as an organic filler for sealing materials for semiconductors and adhesives for semiconductors. The non-thermofusible phenol resin powder is also useful as a precursor of functional carbon materials such as a molecular sieve carbon and a carbon electrode material.
    Type: Grant
    Filed: September 4, 2009
    Date of Patent: April 2, 2013
    Assignee: Air Water Inc.
    Inventors: Naoto Yoshinaga, Yoshiharu Wakayama, Satoshi Ibaraki, Jun Shimomura, Yoshimi Murage, Niro Shiomi, Yoshinobu Kodani, Takaomi Ikeda
  • Patent number: 8362187
    Abstract: Disclosed is a thermofusible and thermosetting phenol resin powder having an average particle diameter of not more than 20 ?m and a single particle ratio of not less than 0.7. This phenol resin powder preferably has an average particle diameter of not more than 10 ?m, a variation coefficient of the particle size distribution of not more than 0.65, a particle sphericity of not less than 0.5 and a free phenol content of not more than 1000 ppm. Also disclosed are a dispersion liquid of such a phenol resin powder, and a method for producing a phenol resin powder having such characteristics.
    Type: Grant
    Filed: October 12, 2007
    Date of Patent: January 29, 2013
    Assignee: Air Water Inc.
    Inventors: Naoto Yoshinaga, Yoshiharu Wakayama, Satoshi Ibaraki, Jun Shimomura, Yoshimi Murage
  • Patent number: 8293860
    Abstract: Disclosed is a non-thermofusible phenol resin powder having an average particle diameter of not more than 20 ?m and a single particle ratio of not less than 0.7. This non-thermofusible phenol resin powder preferably has a chlorine content of not more than 500 ppm. This non-thermofusible phenol resin powder is useful as an organic filler for sealing materials for semiconductors and adhesives for semiconductors. The non-thermofusible phenol resin powder is also useful as a precursor of functional carbon materials such as a molecular sieve carbon and a carbon electrode material.
    Type: Grant
    Filed: October 12, 2007
    Date of Patent: October 23, 2012
    Assignee: Air Water Inc.
    Inventors: Naoto Yoshinaga, Yoshiharu Wakayama, Satoshi Ibaraki, Jun Shimomura, Yoshimi Murage, Niro Shiomi, Yoshinobu Kodani, Takaomi Ikeda
  • Publication number: 20120237830
    Abstract: Disclosed is a non-thermofusible phenol resin powder having an average particle diameter of not more than 20 ?m and a single particle ratio of not less than 0.7. This non-thermofusible phenol resin powder preferably has a chlorine content of not more than 500 ppm. This non-thermofusible phenol resin powder is useful as an organic filler for sealing materials for semiconductors and adhesives for semiconductors. The non-thermofusible phenol resin powder is also useful as a precursor of functional carbon materials such as a molecular sieve carbon and a carbon electrode material.
    Type: Application
    Filed: March 14, 2012
    Publication date: September 20, 2012
    Inventors: Naoto YOSHINAGA, Yoshiharu Wakayama, Satoshi Ibaraki, Jun Shimomura, Yoshimi Murage, Niro Shiomi, Yoshinobu Kodani, Takaomi Ikeda
  • Publication number: 20120135238
    Abstract: Disclosed is a non-thermofusible phenol resin powder having an average particle diameter of not more than 20 ?m and a single particle ratio of not less than 0.7. This non-thermofusible phenol resin powder preferably has a chlorine content of not more than 500 ppm. This non-thermofusible phenol resin powder is useful as an organic filler for sealing materials for semiconductors and adhesives for semiconductors. The non-thermofusible phenol resin powder is also useful as a precursor of functional carbon materials such as a molecular sieve carbon and a carbon electrode material.
    Type: Application
    Filed: February 2, 2012
    Publication date: May 31, 2012
    Inventors: Naoto Yoshinaga, Yoshiharu Wakayama, Satoshi Ibaraki, Jun Shimomura, Yoshimi Murage, Niro Shiomi, Yoshinobu Kodani, Takaomi Ikeda
  • Patent number: 8158095
    Abstract: Disclosed is a non-thermofusible phenol resin powder having an average particle diameter of not more than 20 ?m and a single particle ratio of not less than 0.7. This non-thermofusible phenol resin powder preferably has a chlorine content of not more than 500 ppm. This non-thermofusible phenol resin powder is useful as an organic filler for sealing materials for semiconductors and adhesives for semiconductors. The non-thermofusible phenol resin powder is also useful as a precursor of functional carbon materials such as a molecular sieve carbon and a carbon electrode material.
    Type: Grant
    Filed: September 4, 2009
    Date of Patent: April 17, 2012
    Assignee: Air Water Inc.
    Inventors: Naoto Yoshinaga, Yoshiharu Wakayama, Satoshi Ibaraki, Jun Shimomura, Yoshimi Murage, Niro Shiomi, Yoshinobu Kodani, Takaomi Ikeda
  • Publication number: 20100086782
    Abstract: Disclosed is a thermofusible and thermosetting phenol resin powder having an average particle diameter of not more than 20 ?m and a single particle ratio of not less than 0.7. This phenol resin powder preferably has an average particle diameter of not more than 10 ?m, a variation coefficient of the particle size distribution of not more than 0.65, a particle sphericity of not less than 0.5 and a free phenol content of not more than 1000 ppm. Also disclosed are a dispersion liquid of such a phenol resin powder, and a method for producing a phenol resin powder having such characteristics.
    Type: Application
    Filed: October 12, 2007
    Publication date: April 8, 2010
    Inventors: Naoto Yoshinaga, Yoshiharu Wakayama, Satoshi Ibaraki, Jun Shimomura, Yoshimi Murage
  • Publication number: 20100074831
    Abstract: Disclosed is a non-thermofusible phenol resin powder having an average particle diameter of not more than 20 ?m and a single particle ratio of not less than 0.7. This non-thermofusible phenol resin powder preferably has a chlorine content of not more than 500 ppm. This non-thermofusible phenol resin powder is useful as an organic filler for sealing materials for semiconductors and adhesives for semiconductors. The non-thermofusible phenol resin powder is also useful as a precursor of functional carbon materials such as a molecular sieve carbon and a carbon electrode material.
    Type: Application
    Filed: September 4, 2009
    Publication date: March 25, 2010
    Inventors: Naoto Yoshinaga, Yoshiharu Wakayama, Satoshi Ibaraki, Jun Shimomura, Yoshimi Murage, Niro Shiomi, Yoshinobu Kodani, Takaomi Ikeda
  • Publication number: 20100075228
    Abstract: Disclosed is a non-thermofusible phenol resin powder having an average particle diameter of not more than 20 ?m and a single particle ratio of not less than 0.7. This non-thermofusible phenol resin powder preferably has a chlorine content of not more than 500 ppm. This non-thermofusible phenol resin powder is useful as an organic filler for sealing materials for semiconductors and adhesives for semiconductors. The non-thermofusible phenol resin powder is also useful as a precursor of functional carbon materials such as a molecular sieve carbon and a carbon electrode material.
    Type: Application
    Filed: September 4, 2009
    Publication date: March 25, 2010
    Inventors: Naoto Yoshinaga, Yoshiharu Wakayama, Satoshi Ibaraki, Jun Shimomura, Yoshimi Murage, Niro Shiomi, Yoshinobu Kodani, Takaomi Ikeda
  • Publication number: 20100004356
    Abstract: Disclosed is a non-thermofusible phenol resin powder having an average particle diameter of not more than 20 ?m and a single particle ratio of not less than 0.7. This non-thermofusible phenol resin powder preferably has a chlorine content of not more than 500 ppm. This non-thermofusible phenol resin powder is useful as an organic filler for sealing materials for semiconductors and adhesives for semiconductors. The non-thermofusible phenol resin powder is also useful as a precursor of functional carbon materials such as a molecular sieve carbon and a carbon electrode material.
    Type: Application
    Filed: October 12, 2007
    Publication date: January 7, 2010
    Inventors: Naoto Yoshinaga, Yoshiharu Wakayama, Satoshi Ibaraki, Jun Shimormura, Yoshimi Murage, Niro Shiomi, Yoshinobu Kodani, Takaomi Ikeda