Abstract: Provided are functional drug-containing particles which can be compressed into tablets and in particular, to orally disintegrating tablets by employing any of a dry molding method, a wet molding method, or a humidifying drying method. The functional drug-containing particles comprise substantially spherical drug-containing particles essentially including drug and a binder, the functional drug-containing particles including a functional polymer film selected from the group consisting of an enteric film, a release control film, and a bitter taste masking film, an average particle diameter of said functional drug-containing particles being 400 ?m or less, a particle diameter ratio D90/D10 of the functional drug-containing particles with respect to particle size distribution calculated on a volumetric basis being 1.65 or more, or a coefficient of variation in particle diameters being 24% or more.

Abstract: Provided are functional drug-containing particles which can be compressed into tablets and in particular, to orally disintegrating tablets by employing any of a dry molding method, a wet molding method, or a humidifying drying method. The functional drug-containing particles comprise substantially spherical drug-containing particles essentially including drug and a binder, the functional drug-containing particles including a functional polymer film selected from the group consisting of an enteric film, a release control film, and a bitter taste masking film, an average particle diameter of said functional drug-containing particles being 400 ?m or less, a particle diameter ratio D90/D10 of the functional drug-containing particles with respect to particle size distribution calculated on a volumetric basis being 1.65 or more, or a coefficient of variation in particle diameters being 24% or more.

Abstract: A partition portion includes a proximal portion fixed to the outer periphery of the peripheral wall portion and a sealing member mounted to the proximal portion in a manner that the sealing member is allowed to move in inner and outer circumferential directions of the peripheral wall portion. When receiving a force toward an outer circumferential direction, the sealing member is moved in the outer circumferential direction, and a distal end portion thereof is held in press-contact with a sliding contact portion of a ventilation member with a force generated along with the above-mentioned force.

Abstract: A partition portion includes a proximal portion fixed to the outer periphery of the peripheral wall portion and a sealing member mounted to the proximal portion in a manner that the sealing member is allowed to move in inner and outer circumferential directions of the peripheral wall portion. When receiving a force toward an outer circumferential direction, the sealing member is moved in the outer circumferential direction, and a distal end portion thereof is held in press-contact with a sliding contact portion of a ventilation member with a force generated along with the above-mentioned force.

Abstract: There is provided a method for producing resinous particles, containing: melting a mixture containing a binder resin and at least one additive having a melting point lower than T1/2 of the binder resin so as to prepare a molten material; atomizing resinous particles from the molten material in an atmosphere having a temperature higher than Tg of the binder resin and lower than 3 times of T1/2 of the binder resin; retaining the resinous particles in an atmosphere having a temperature higher than Tg of the binder resin, and lower than 1.5 times of T1/2 of the binder resin for 1 s to 15 s; and cooling and solidifying the resinous particles.

Abstract: There is provided a method for producing resinous particles, containing: melting a mixture containing a binder resin and at least one additive having a melting point lower than T1/2 of the binder resin so as to prepare a molten material; atomizing resinous particles from the molten material in an atmosphere having a temperature higher than Tg of the binder resin and lower than 3 times of T1/2 of the binder resin; retaining the resinous particles in an atmosphere having a temperature higher than Tg of the binder resin, and lower than 1.5 times of T1/2 of the binder resin for 1 s to 15 s; and cooling and solidifying the resinous particles.

Abstract: There is provided a method for producing resinous particles, containing: melting a mixture containing a binder resin and at least one additive having a melting point lower than T1/2 of the binder resin so as to prepare a molten material; atomizing resinous particles from the molten material in an atmosphere having a temperature higher than Tg of the binder resin and lower than 3 times of T1/2 of the binder resin; retaining the resinous particles in an atmosphere having a temperature higher than Tg of the binder resin, and lower than 1.5 times of T1/2 of the binder resin for 1 s to 15 s; and cooling and solidifying the resinous particles.

Abstract: An apparatus for manufacturing a particulate resin, including: a fine nozzle opening configured to extrude a melted resin mixture including a resin; an extrusion output control mechanism for controlling an extrusion output of the melted resin mixture; a collision mechanism configured to collide the melted resin mixture extruded from the fine nozzle opening with a high-temperature gas stream having a temperature of not less than a T1/2 temperature of the resin, so that the melted resin mixture is granulated to provide a particulate resin; a heat retention mechanism configured to retain the particulate resin in an atmosphere having a temperature of not less than a Tg of the resin for 0.01 to 10 seconds; and a cooling mechanism configured to cool the particulate resin; and a method for manufacturing a particulate resin using the apparatus.

Abstract: A method of preparing a powder, including bombarding a spray gas to a liquid material through a spray nozzle to form an atomized liquid material; and solidifying the atomized liquid material, wherein 5 to 40% by weight of the spray gas are previously mixed with the liquid material to form a two-phase flow in a flow path of the spray nozzle, and 60 to 95% by weight of the spray gas is further discharged from a circumference of the flow path discharging the two-phase flow and bombarded thereto to uniformly atomize the liquid material.

Abstract: To provide a method including processing electrophotographic toner constituent material to a fibrous fine precursor and pulverizing and cutting it to obtain a uniform fibrous toner with energy efficiency in an apparatus for producing electrophotographic toner including a nozzle unit containing a nozzle having a flow path tapering toward the nozzle hole at 2° to 20° and a gas nozzle unit containing a gas nozzle and gas flow path tapering toward the nozzle hole at 15° to 33° relative to a direction of a nozzle axis, wherein the toner constituent material containing a raw material A containing a resin and pigment, and a raw material B containing one of a low melting point resin, wax and organic solvent, is extruded from the nozzle at 150° C. to 320° C., and drawn by gas flow from the gas nozzles so as to be a fibrous fluid while controlling the flow rate.

Abstract: A method for coating particles with a coating liquid including supplying airflow to fluidize the particles; mixing the coating liquid with a spray gas in a two-fluid spray nozzle to form a two-phase flow; and atomizing the two-phase flow with the spray gas to spray a mist of the coating liquid upon the particles. A coating device including a vessel; a fluidizing device configured to supply airflow to fluidize a powder in the vessel; and a spray nozzle configured to mix the coating liquid with a spray gas to form a two-phase flow, and to atomize the two-phase flow with the spray gas to spray a mist of the coating liquid. A particulate carrier for use in electrophotographic developer including particles of a core material and a cover layer thereon and prepared by the coating method mentioned above.

Abstract: There is provided a method for producing resinous particles, containing: melting a mixture containing a binder resin and at least one additive having a melting point lower than T1/2 of the binder resin so as to prepare a molten material; atomizing resinous particles from the molten material in an atmosphere having a temperature higher than Tg of the binder resin and lower than 3 times of T1/2 of the binder resin; retaining the resinous particles in an atmosphere having a temperature higher than Tg of the binder resin, and lower than 1.5 times of T1/2 of the binder resin for 1 s to 15 s; and cooling and solidifying the resinous particles.

Abstract: A method of preparing a powder, including bombarding a spray gas to a liquid material through a spray nozzle to form an atomized liquid material; and solidifying the atomized liquid material, wherein 5 to 40% by weight of the spray gas are previously mixed with the liquid material to form a two-phase flow in a flow path of the spray nozzle, and 60 to 95% by weight of the spray gas is further discharged from a circumference of the flow path discharging the two-phase flow and bombarded thereto to uniformly atomize the liquid material.

Abstract: An apparatus for manufacturing a particulate resin, including: a fine nozzle opening configured to extrude a melted resin mixture including a resin; an extrusion output control mechanism for controlling an extrusion output of the melted resin mixture; a collision mechanism configured to collide the melted resin mixture extruded from the fine nozzle opening with a high-temperature gas stream having a temperature of not less than a T1/2 temperature of the resin, so that the melted resin mixture is granulated to provide a particulate resin; a heat retention mechanism configured to retain the particulate resin in an atmosphere having a temperature of not less than a Tg of the resin for 0.01 to 10 seconds; and a cooling mechanism configured to cool the particulate resin; and a method for manufacturing a particulate resin using the apparatus.

Abstract: To provide a method including processing electrophotographic toner constituent material to a fibrous fine precursor and pulverizing and cutting it to obtain a uniform fibrous toner with energy efficiency in an apparatus for producing electrophotographic toner including a nozzle unit containing a nozzle having a flow path tapering toward the nozzle hole at 2° to 20° and a gas nozzle unit containing a gas nozzle and gas flow path tapering toward the nozzle hole at 15° to 33° relative to a direction of a nozzle axis, wherein the toner constituent material containing a raw material A containing a resin and pigment, and a raw material B containing one of a low melting point resin, wax and organic solvent, is extruded from the nozzle at 150° C. to 320° C., and drawn by gas flow from the gas nozzles so as to be a fibrous fluid while controlling the flow rate.

Abstract: A production process characterized by fluidizing resin particles as a base powder and spraying the fluidized particles with a slurry containing a pigment dispersed therein to coat the surface of the resin particles with the pigment.

Abstract: A strong pressure and a strong shearing force are exerted to a mixture, constituted of two kinds or more of powder materials including a drug powder, while causing the mixture to pass between a press section (26) of a press head (24) and a receiving surface (25) of a cylindrical rotator (23), thereby combining the drug powder with the other powder material. For example, at least one of a drug and a biocompatible polymer is made into a nano particle whose average particle diameter is less than 1000 nm, and the nano particle is made into a composite in accordance with a dry mechanical particle combining method, so as to form a polymer nano composite particle. Thus, it is possible to produce a composite particle, which contains a drug under a stable condition, in a short time, and it is possible to remarkably improve its handling property without losing advantages of the nano particle.