Abstract: It is intended to reveal a polynucleotide serving as a novel causative gene of a cancer and, on the basis of this finding, to provide a method for detecting the polynucleotide or a polypeptide encoded thereby, a kit and a primer set for the detection, a method for screening for a substance that inhibits the polypeptide, and a pharmaceutical composition for the treatment of a cancer, containing the inhibiting substance. The detection method of the present invention detects a BRAF fusion protein or a fusion gene encoding the fusion protein, or a PXN or GMDS fusion protein or a fusion gene encoding the fusion protein in a digestive organ-derived sample obtained from a subject.

Abstract: A thermal device according to the present disclosure includes a ceramic container, a fluid, and a sealing portion. The container includes an internal space, an opening portion connected to the internal space, and a communication path configured to connect the internal space and the opening portion. The fluid is located in the internal space. The sealing portion blocks the opening portion. The sealing portion includes a core portion and a flange connected to the core portion. The flange is bonded to the container around the opening portion. The core portion is located inside the opening portion. A portion of the core portion is in contact with the wall surface of the opening portion.

Abstract: A semiconductive ceramic member according to the present disclosure contains a plurality of aluminum oxide crystal grains, and a plurality of titanium oxide crystal grains. The total content of aluminum oxide and titanium oxide is 99% by mass or more per 100% by mass of all constituents. The content of the aluminum oxide is 86% by mass or more and 96% by mass or less and the content of the titanium oxide is 4% by mass or more and 14% by mass or less per 100% by mass of the aluminum oxide and the titanium oxide in total. A peak of TiOx (0<x<2) is present within a binding energy range of 456 eV to 462 eV (both inclusive) in X-ray photoelectron spectroscopy measurement. The semiconductive ceramic member further contains silicon, and the content of the silicon in terms of its oxide in a first region is larger than the content of the silicon in terms of its oxide in a grain boundary.

Abstract: In production of crops of agriculture and horticulture or the like, damage caused by diseases is still large, and, due to factors such as occurrence of resistant diseases to existing drugs, development of new agrohorticultural fungicides is desired. The present invention provides an agrohorticultural fungicide and a method of use thereof of, an active ingredient thereof being a compound represented by the general formula (I) or salts thereof: {wherein X1, X2, X3 and X4 denote a hydrogen atom or the like, A, B, Y, denote a single bond or carbonyl group or the like, Q denotes a (C1-C6)alkyl group or hetero ring or the like, R5 and R6 denote a hydrogen atom or (C1-C6)alkyl group or the like.}.

Abstract: A thermal device according to the present disclosure includes a ceramic container, a fluid, and a sealing portion. The container includes an internal space, an opening portion connected to the internal space, and a communication path configured to connect the internal space and the opening portion. The fluid is located in the internal space. The sealing portion blocks the opening portion. The sealing portion includes a core portion and a flange connected to the core portion. The flange is bonded to the container around the opening portion. The core portion is located inside the opening portion. A portion of the core portion is in contact with the wall surface of the opening portion.

Abstract: Described is a method for differentiating destructive thyroiditis, including measuring at least one of monoiodotyrosine and diiodotyrosine in a sample.

Abstract: An X-ray diagnosis apparatus according to the present embodiment comprises: an X-ray irradiator configured to irradiate X-rays; an imager configured to image an identifier that identifies a position of an X-ray detector which detects X-rays; and processing circuitry configured to calculate, based on the identifier shown on an image imaged by the imager, a relative position of the X-ray irradiator regarding the X-ray detector and an irradiation position of the X-ray irradiator where a corresponding relative position meets a predetermined X-ray imaging condition; and output, based on the relative position and the irradiation position, a movement information of the X-ray irradiator.

Abstract: An x-ray diagnostic apparatus according to an embodiment includes a radiographic unit, a movable unit, and processing circuitry. The radiographic unit performs radiography. The movable unit is provided in the radiographic unit and is movable to plural positions. The processing circuitry moves the movable unit to a position where the movable unit and a disinfection apparatus that performs disinfection have a predetermined positional relation to each other.

Abstract: In production of crops of agriculture and horticulture or the like, damage caused by diseases is still large, and, due to factors such as occurrence of resistant diseases to existing drugs, development of new agrohorticultural fungicides is desired. The present invention provides an agrohorticultural fungicide and a method of use thereof of, an active ingredient thereof being a compound represented by the general formula (I) or salts thereof: {wherein X1, X2, X3 and X4 denote a hydrogen atom or the like, A, B, Y, denote a single bond or carbonyl group or the like, Q denotes a (C1-C6)alkyl group or hetero ring or the like, R5 and R6 denote a hydrogen atom or (C1-C6)alkyl group or the like.}.

Abstract: The object of the present invention is to provide a humanized or mouse-human chimeric anti-podoplanin antibody or an antibody fragment containing the antigen-binding region thereof, and the object is achieved by providing an isolated humanized or mouse-human chimeric anti-podoplanin antibody which comprises a predetermined amino acid sequence, or an antibody fragment containing the antigen-binding region thereof.

Abstract: In production of crops of agriculture and horticulture or the like, damage caused by diseases is still large, and, due to factors such as occurrence of resistant diseases to existing drugs, development of new agrohorticultural fungicides is desired. General formula (I) As a result of intensive research to develop novel fungicides, the present inventors found that the compound represented by the general formula (I) of the present invention or a salt thereof is useful as an agrohorticultural fungicide to complete the present invention.

Abstract: A drug containing, as an active ingredient, a compound represented by ALK inhibitors such as brigatinib, AP26113-analog, and AZD3463 has been found to be effective against a non-small cell lung cancer having a point mutation at C797S in EGFR which has acquired a resistance to chemotherapy agents. Further, the drug used in combination with an anti-EGFR antibody demonstrates a notable suppression effect on the tumor growth. The drug has a potential to be a therapeutic agent effective against a non-small cell lung cancer which is resistant to gefitinib, a first generation therapeutic agent and osimertinib, a third generation therapeutic agent.

Abstract: In production of crops of agriculture and horticulture or the like, damage caused by diseases is still large, and, due to factors such as occurrence of resistant diseases to existing drugs, development of new agrohorticultural fungicides is desired. The present invention provides an agrohorticultural fungicide and a method of use thereof, an active ingredient thereof being a compound represented by the general formula (I) or salts thereof: {wherein R1 denotes a hydrogen atom or (C1-C6)alkyl group or the like. R2 denotes a hydrogen atom or the like. R3 denotes a hydrogen atom or (C1-C6)alkyl group or the like. R4 denotes a (C1-C6)alkyl group, (C3-C6)cycloalkyl group or aryl group or the like. X1 and X2 denote a hydrogen atom or halogen atom or the like. Y denotes an oxygen atom.}.

Abstract: An electrical discharge machining method includes selectively immersing only a portion of a workpiece in an electrical discharge machining liquid such that a machining object portion included in the portion of the workpiece is opposed to an electrode immersed in the electrical discharge machining liquid and applying an electrical discharge machining to the machining object portion by applying a voltage between the electrode and the workpiece in a state where the portion of the workpiece is selectively immersed in the electrical discharge machining liquid.

Abstract: A semiconductive ceramic member according to the present disclosure contains a plurality of aluminum oxide crystal grains, and a plurality of titanium oxide crystal grains. The total content of aluminum oxide and titanium oxide is 99% by mass or more per 100% by mass of all constituents. The content of the aluminum oxide is 86% by mass or more and 96% by mass or less and the content of the titanium oxide is 4% by mass or more and 14% by mass or less per 100% by mass of the aluminum oxide and the titanium oxide in total. A peak of TiOx (0<x<2) is present within a binding energy range of 456 eV to 462 eV (both inclusive) in X-ray photoelectron spectroscopy measurement. The semiconductive ceramic member further contains silicon, and the content of the silicon in terms of its oxide in a first region is larger than the content of the silicon in terms of its oxide in a grain boundary.

Abstract: An image displaying system according to an embodiment includes an observation target device, a display device and processing circuitry. The display device is configured to display an image. The processing circuitry is configured to: arrange a three-dimensional model relating to the observation target device in a virtual space; acquire data indicating a relative positional relationship between an operator and the observation target device; generate an image of a three-dimensional model included in a blind area when viewed from the operator, based on the data indicating the relative positional relationship and on the three-dimensional model arranged in the virtual space; and display the image on the display device.

Abstract: The object of the present invention is to provide a humanized or mouse-human chimeric anti-podoplanin antibody or an antibody fragment containing the antigen-binding region thereof, and the object is achieved by providing an isolated humanized or mouse-human chimeric anti-podoplanin antibody which comprises a predetermined amino acid sequence, or an antibody fragment containing the antigen-binding region thereof.

Abstract: The development of novel agricultural/horticultural fungicides is desired due to damage by diseases continuing to be a major issue, the evolution of diseases resistant to existing chemicals, and other such factors in crop production such as agriculture and horticulture. The present invention provides an agricultural/horticultural fungicide having as an active ingredient a compound represented by general formula (I) [in the formula, R1 represents an (a2) (C1-C6) alkyl group, etc. R2 represents a (b1) hydrogen atom, etc. R3 represents a (c1) hydrogen atom or a (c2) (C1-C6) alkyl group, etc. R4 represents a (d2) (C1-C6) alkyl group, etc. X1, X2, X3, and X4 represent an (e1) hydrogen atom, etc. Y represents an oxygen atom, etc.] or salts thereof, and a method for using the same.

Abstract: It is intended to reveal a polynucleotide serving as a novel causative gene of a cancer and, on the basis of this finding, to provide a method for detecting the polynucleotide or a polypeptide encoded thereby, a kit and a primer set for the detection, a method for screening for a substance that inhibits the polypeptide, and a pharmaceutical composition for the treatment of a cancer, containing the inhibiting substance. The detection method of the present invention detects a BRAF fusion protein or a fusion gene encoding the fusion protein, or a PXN or GMDS fusion protein or a fusion gene encoding the fusion protein in a digestive organ-derived sample obtained from a subject.

Abstract: A turbine blade designing method is for designing a turbine blade formed using a metal material in which creep including diffusion creep and dislocation creep occurs by heating. The turbine blade designing method includes: acquiring temperature distribution data relating to temperature distribution in the turbine blade to be heated; acquiring creep strength distribution data relating to distribution of the creep strength required for the turbine blade to be heated; from the correlation data, based on the temperature distribution data and the creep strength distribution data, setting the crystal grain size of a high-temperature portion that is the diffusion creep temperature range of the turbine blade to a size coarser than the reference crystal grain size, and setting the crystal grain size of a low-temperature portion that is the dislocation creep temperature range of the turbine blade to a size finer than the reference crystal grain size.