Abstract: The present invention has an object to provide a D-mannose isomerase of membrane-bound form having the optimal reaction pH in acidic region. The membrane-bound D-mannose isomerase derived from acetic acid bacteria is produced. The acetic acid bacteria are preferably belong to the genera of Acetobacter, Gluconobacter, or Gluconacetobacter. Furthermore, the membrane-bound D-mannose isomerase from the acetic acid bacteria is used to produce D-fructose from D-mannose.

Abstract: An outer needle assembly 10 comprises an outer needle 48 wherethrough an inner needle 16 passes, and a passage forming member 50 connected to the outer needle 48 and including a valve body 64 inside such that a first internal space 78 on a distal side of the valve body 64 is longer than a second internal space 79 on a proximal side thereof. A ventilation path 80 for discharging air to an outside communicates with the first internal space 78 near the valve body 64. The first internal space 78 comprises: a puncture part 56 formed in a puncturing portion of the outer needle 48; a tapered part 57 formed on the proximal side of the puncture part 56 with an inner diameter increasing toward the proximal side; and a small-diameter part 89 formed on the proximal side of the tapered part 57 with an inner diameter smaller than or equal to that of a proximal end of the tapered part 57.

Abstract: A needle cap and a dialysis circuit priming device with increased safety and convenience in the cleaning and priming of a blood circuit are provided. According to the present invention, a needle cap is provided including two needle connecting parts, and a flow path connecting the two needle connecting parts. A dialysis circuit priming device is also provided including two needles, two needle connecting parts each arranged with the two needles respectively, and a flow path for connecting the two needle connecting parts.

Abstract: The invention provides gastroenterological cancer determination methods that involve contacting a specimen, an antibody 1 that recognizes an ? chain of human haptoglobin, and an antibody 2 that recognizes a ? chain of human haptoglobin and does not recognize human haptoglobin in which an S—S bond is cleaved to form a complex 1, or contacting the specimen and two antibodies selected from the antibodies 2 that recognize a ? chain of human haptoglobin and do not recognize human haptoglobin in which an S—S bond is cleaved to form a complex 2. A determination is made based on the measurement of complex 1 or 2. Alternatively, the specimen and two antibodies selected from the antibodies 1 that recognize an ? chain of human haptoglobin are contacted to form a complex 3, and a determination is made by comparing the measurement results of complex 1 or 2 with complex 3.

Abstract: A puncturing tool for small animals which has a novel structure, facilitates confirmation of the connection state of a capillary tube, and can prevent inadvertent detachment of the capillary tube. A puncturing tool for small animals includes a connecting part for a capillary tube on the proximal end side of a hollow needle, wherein the connecting part has a tapered peripheral wall that expanding and extending in a direction away from the hollow needle, and a tapered peripheral wall has an elastic fitting part, through which the capillary tube is inserted, projecting inward from a middle portion of the tapered peripheral wall in the length direction thereof.

Abstract: A damper apparatus includes a first rotating body, a second rotating body, and an elastic mechanism unit including an elastic body and paired seat members. The seat member includes a first surface portion coming into contact with one of the first rotating body and the second rotating body and a second surface portion coming into contact with another of the first rotating body and the second rotating body, a first angle ?1 formed by a first tangent line at a first point of contact, the first tangent line including a first vector and a second vector, and the first vector is 11.5°??1?22.0°, and a second angle ?2 formed by a second tangent line at a second point of contact, the second tangent line including a third vector and a fourth vector, and the third vector is 11.5°??2?22.0°.

Abstract: The invention provides gastroenterological cancer determination methods that involve contacting a specimen, an antibody 1 that recognizes an ? chain of human haptoglobin, and an antibody 2 that recognizes a ? chain of human haptoglobin and does not recognize human haptoglobin in which an S—S bond is cleaved to form a complex 1, or contacting the specimen and two antibodies selected from the antibodies 2 that recognize a ? chain of human haptoglobin and do not recognize human haptoglobin in which an S—S bond is cleaved to form a complex 2. A determination is made based on the measurement of complex 1 or 2. Alternatively, the specimen and two antibodies selected from the antibodies 1 that recognize an ? chain of human haptoglobin are contacted to form a complex 3, and a determination is made by comparing the measurement results of complex 1 or 2 with complex 3.

Abstract: A needle cap and a dialysis circuit priming device with increased safety and convenience in the cleaning and priming of a blood circuit are provided. According to the present invention, a needle cap is provided including two needle connecting parts, and a flow path connecting the two needle connecting parts. A dialysis circuit priming device is also provided including two needles, two needle connecting parts each arranged with the two needles respectively, and a flow path for connecting the two needle connecting parts.