Abstract: This invention is in the field of medicinal chemistry and relates to a new class of small-molecules having a N-methyl-1-(naphthalen-1-yl)ethan-1-amine (or similar) structure (e.g.: Formula I) which function as inhibitors of the SARS-CoV-2 papain-like protease (PLpro), which function as therapeutics for the treatment of viral infection characterized with PLpro protease activity and/or expression (e.g., COVID-19), and which function as therapeutics for the treatment of other conditions characterized with PLpro protease activity and/or expression.

Abstract: An information processing device includes a controller configured to acquire a record of a predetermined action for maintaining a commercial value of a first vehicle by a first user who rents the first vehicle from a first service that is a vehicle rental service, and provide an incentive to the first user when the record of the predetermined action is at a level equal to or higher than a predetermined reference.

Abstract: This invention is in the field of medicinal chemistry and relates to a new class of small-molecules having a methyl-acetamido-propanamide structure (e.g., Formula I) which function as inhibitors of the SARS-CoV-2 main protease (Mpro), which function as therapeutics for the treatment of viral infection characterized with Mpro protease activity and/or expression (e.g., COVID-19), and which function as therapeutics for the treatment of other conditions characterized with Mpro protease activity and/or expression.

Abstract: Provided is a tire having a tread portion with a thickness of 15 mm or less, wherein the cap rubber layer forming the tread portion is formed from a rubber composition containing 40 parts by mass or more and 80 parts by mass or less of styrene-butadiene rubber (SBR) with a styrene content of 25% by mass or less, in 100 parts by mass of the rubber component, and in addition to the rubber component, containing silica and carbon black; and having loss tangent 30° C. tan ? of more than 0.18 measured under the conditions of temperature of 30° C., frequency of 10 Hz, initial strain of 5%, dynamic strain rate of 1%, and deformation mode: tensile; wherein the carbon black content is 15 parts by mass or more with respect to 100 parts by mass of the rubber component, and the ratio of the silica content to the carbon black content is 1 or more; and an object of the present invention is to improve chipping resistance performance when running on a rough road surface at high speed.

Abstract: A tire having a tread portion, which can suppress deterioration in braking performance of tires on an icy road surface after repeated running; and the cap rubber layer forming the tread portion is formed from a rubber composition containing 40 parts by mass or more and 80 parts by mass or less of styrene-butadiene rubber (SBR) having a styrene content of 25% by mass or less in 100 parts by mass of the rubber component, containing silica and carbon black together with the rubber component, and having the loss tangent 30° C. tan ? of less than 0.25 measured under the conditions of temperature of 30° C., frequency of 10 Hz, initial strain of 5%, dynamic strain rate of 1%, and deformation mode: tensile; in the rubber composition, the carbon black content is more than 15 parts by mass with respect to 100 parts by mass of the rubber component, and the ratio of the silica content to the carbon black content is 1 or more; and the thickness of the tread portion is 15 mm or less.

Abstract: This invention is in the field of medicinal chemistry and relates to a new class of small-molecules having a pyrazolopyridine (or similar) structure (e.g., Formula I) which function as inhibitors of the viral protein 2C protein activity and/or expression, and which function as therapeutics for the treatment of viral infection characterized with viral protein 2C activity and/or expression (e.g., non-polio enterovirus infection) (e.g., enterovirus D68 (EV-D68) infection, enterovirus A71 (EV-A71) infection, and coxsackievirus B3 (CVB3) infection.

Abstract: Provided is an agent for improving symptoms of menopause which is useful to improve symptoms of menopause. The agent for improving symptoms of menopause comprises delphinidin-3-rutinoside, cyanidin-3-rutinoside, or a combination thereof as an active ingredient.

Abstract: An agent for preventing or ameliorating nocturia, containing rosmarinic acid or a salt thereof as an active ingredient.

Abstract: This invention is in the field of medicinal chemistry and relates to a new class of small-molecules having a pyrazolopyridine (or similar) structure (e.g., Formula I) which function as inhibitors of the viral protein 2C protein activity and/or expression, and which function as therapeutics for the treatment of viral infection characterized with viral protein 2C activity and/or expression (e.g., non-polio enterovirus infection) (e.g., enterovirus D68 (EV-D68) infection, enterovirus A71 (EV-A71) infection, and coxsackievirus B3 (CVB3) infection.

Abstract: Provided is a tire comprising a tread formed of a rubber composition comprising a rubber component comprising 0 to 50% by mass of an isoprene-based rubber, wherein the tire satisfies the following conditions (1) to (6): (1) when a tan ? at 30° C. (tan ?30° C.) is A, A?0.12, (2) when a ratio (EB80° C./EB23° C.) of an elongation at break at 80° C. (EB80° C.) to an elongation at break at 23° C. (EB23° C.) is B, 0.60?B?1.00, and (3) when an abrasion resistance index with a tire of Comparative example 1 being 100 as measured by a LAT tester is C, 110?C?140, (4) when a ratio (LANDSh/LANDCr) of a land ratio of the entire pair of shoulder parts (LANDSh) to a land ratio of the crown part (LANDCr) is D, 0.80?D?2.00, (5) when a maximum groove depth of the circumferential main groove is E (mm), 5?E?20, and 2 ? 5 ? ( B × C / A ) × ( D / E ) ? 2 ? 0 ? 0 .

Abstract: Provided is a compound that inhibits the activity of TRPV4 and is useful for preventing or ameliorating overactive bladder, irritable bowel syndrome, and the like. A TRPV4 activity inhibitor is provided containing a rosmarinic acid derivative selected from the group consisting of the following formulas (Ia) to (Id), or a salt thereof, as an active ingredient.

Abstract: The present invention provides a compound that inhibits the activity of TRPV4 and is useful for prevention or amelioration of an overactive bladder, an irritable bowel syndrome, etc.

Abstract: An agent for preventing or ameliorating nocturia, containing rosmarinic acid or a salt thereof as an active ingredient.

Abstract: The present invention provides a rubber composition for tires which can improve crack resistance, ozone resistance, discoloration resistance, and tire appearance while maintaining a good balance between them, and also provides a pneumatic tire formed from the rubber composition. The present invention relates to a rubber composition for tires, containing a rubber component having a combined content of polybutadiene rubber, natural rubber, and polyisoprene rubber of 80% by mass or more per 100% by mass of the rubber component, the rubber composition containing, per 100 parts by mass of the rubber component: 0.1 to 8.0 parts by mass of polyether (A) having a glycol ether content of 80% by mass or more and a HLB of 3.5 to 19.0, the polyether (A) excluding Pluronic nonionic surfactants; 2 to 70 parts by mass of carbon black; and 0.3 to 7.0 parts by mass of an antioxidant.

Abstract: Provided are: a rubber composition for tires that achieves a balanced improvement in handling stability, crack resistance, ozone resistance, discoloration resistance, tire appearance, fuel economy, tensile strength, and scorch resistance; and a pneumatic tire formed from the rubber composition.

Abstract: The present invention aims to provide a rubber composition for tires that can improve processability, crack resistance, ozone resistance, discoloration resistance, and tire appearance while maintaining a good balance between them, and also to provide a pneumatic tire formed from the rubber composition. The present invention relates to a rubber composition for tires, containing: a rubber component; an antioxidant; and polyether, the rubber component having a combined content of polybutadiene rubber, natural rubber, and polyisoprene rubber of 80% by mass or more per 100% by mass of the rubber component, the rubber composition containing the antioxidant in an amount of 0.3 to 7.0 parts by mass per 100 parts by mass of the rubber component, the polyether having an average mass content of at least two consecutive polyethylene oxide units of 85% or less of the polyethylene oxide mass content of the polyether.

Abstract: The present invention provides a rubber composition for tires which can improve crack resistance, ozone resistance, discoloration resistance, and tire appearance while maintaining a good balance between them, and also provides a pneumatic tire formed from the rubber composition. The present invention relates to a rubber composition for tires, containing a rubber component having a combined content of polybutadiene rubber, natural rubber, and polyisoprene rubber of 80% by mass or more per 100% by mass of the rubber component, the rubber composition containing, per 100 parts by mass of the rubber component: 0.1 to 8.0 parts by mass of polyether (A) having a glycol ether content of 80% by mass or more and a HLB of 3.5 to 19.0, the polyether (A) excluding Pluronic nonionic surfactants; 2 to 70 parts by mass of carbon black; and 0.3 to 7.0 parts by mass of an antioxidant.

Abstract: The present invention aims to provide a rubber composition for tires that can improve processability, crack resistance, ozone resistance, discoloration resistance, and tire appearance while maintaining a good balance between them, and also to provide a pneumatic tire formed from the rubber composition. The present invention relates to a rubber composition for tires, containing: a rubber component; an antioxidant; and polyether, the rubber component having a combined content of polybutadiene rubber, natural rubber, and polyisoprene rubber of 80% by mass or more per 100% by mass of the rubber component, the rubber composition containing the antioxidant in an amount of 0.3 to 7.0 parts by mass per 100 parts by mass of the rubber component, the polyether having an average mass content of at least two consecutive polyethylene oxide units of 85% or less of the polyethylene oxide mass content of the polyether.

Abstract: The present invention provides a conductive bonded assembly utilizing particles of Ni or an Ni alloy as conductive particles so as to enable firing under non-pressing conditions and further realize an excellent bonding strength, electron migration characteristic, and ion migration characteristic. The conductive bonded assembly of the present invention is a conductive bonded assembly of an electronic component which has a first bondable member (for example, electrode material), a second bondable member (for example, a semiconductor device on an Si or SiC substrate), and a conductive bonding layer bonding these bondable members together, where the bonding layer is an Ni sintered body formed by a sintered body of Ni particles which has a porosity of 30% or less, and, further, can be obtained by heating and sintering the Ni particles at the time of firing where the Ni sintered bonding layer is formed.

Abstract: Provided are: a rubber composition for tires that achieves a balanced improvement in handling stability, crack resistance, ozone resistance, discoloration resistance, tire appearance, fuel economy, tensile strength, and scorch resistance; and a pneumatic tire formed from the rubber composition.