Abstract: A polypeptide comprising one or more variant Fc regions, each of the variant Fc regions comprising two CH2 domains, wherein at least one of the CH2 domains in at least one of the variant Fc regions is a variant CH2 domain, and wherein amino acid residues at positions 234, 235, and 265 (all positions expressed by EU numbering) of the variant CH2 domain are Ala, Ala, and Gly, or Ala, Ala, and Asn, respectively.

Abstract: A novel antibody that can be used as an anti-tumor agent and an anti-tumor agent that comprises, as an active ingredient, a molecule containing such an antibody.

Abstract: An antibody that can be used as an anti-tumor agent and an anti-tumor agent comprises a molecule containing such an antibody. Such an antibody or a binding fragment thereof comprises: a heavy chain CDRH1 consisting of SEQ ID NO: 54, a heavy chain CDRH2 consisting of SEQ ID NO: 55, a heavy chain CDRH3 consisting of SEQ ID NO: 56, a light chain CDRL1 consisting of SEQ ID NO: 57 or a light chain CDRL1 consisting of an amino acid sequence derived from SEQ ID NO: 57 in which amino acid 7 is W and/or amino acid 8 is K, a light chain CDRL2 consisting of SEQ ID NO: 58, and a light chain CDRL3 consisting of SEQ ID NO: 59 or a light chain CDRL3 consisting of an amino acid sequence derived from SEQ ID NO: 59 in which amino acid 2 is A or S.

Abstract: A novel antibody that can be used as an anti-tumor agent and an anti-tumor agent that comprises, as an active ingredient, a molecule containing such an antibody.

Abstract: The present invention provides a peptide selected from the following (i) and (ii): (i) a peptide having the amino acid sequence represented by SEQ ID NO: 1 in the Sequence Listing; and (ii) a peptide having an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 1 in the Sequence Listing by the conservative amino acid substitution, deletion, addition, or insertion of 1 to 28 (inclusive) amino acids except at the 1st Xaa to the 11th Xaa counting from the amino terminus.

Abstract: The present invention provides a peptide library comprising a plurality of mutant peptides based on the extracellular binding domain of the TACI protein. The mutant peptides of the library have the capacity to bind to target molecules other than the endogenous TACI ligands. The present invention further provides a peptide library comprising a plurality of mutant peptides each comprising an amino acid sequence of SEQ ID NO: 1 in the Sequence Listing.

Abstract: A platform scale provided with an enclosure for surrounding the sides of the platform scale, wherein: the platform scale comprises shock-absorbing members that extend outward at multiple places of the feet, which support the main body of the platform scale on a base; the enclosure is configured from only side walls that surround the sides of the platform scale; the height of the side walls placed on the base is set to be lower than the height of the upper surface of the weighing tray of the platform scale; and the side walls set on the base do not touch portions of the platform scale other than the shock-absorbing members.

Abstract: (Problem) To provide a high precision platform scale (Means to Solve the Problem) A platform scale for weighing an object to be weighed by supporting it by a plurality of load detection sections, wherein the load detection section comprises a load sensor 40 having a block body 42 for transmitting an applied load to a tuning fork vibrator 41 coupled to the block body 42 by reducing the load, a circuit board having fabricated thereon circuitry for converting a signal from the tuning fork vibrator into a digital signal and a sensor case 33 for accommodating the load sensor and the circuit board. The sensor case 33 is made by casting stainless material by a lost wax process and is directly coupled to parallel base frames 20 for maintaining the distance between the base frames. The sensor case has sufficient mechanical strength and also acts as a structural member for the base frames, thereby reducing the number of components and the height of a weighing table.

Abstract: A load detection sensor capable of stably weighing a heavy object to be weighed in high precision. The load detection sensor according to the present invention includes a force sensor including a tuning fork vibrator and a block body that has a rectangular parallelepiped outer shape and transmits an applied load to the force sensor by using a lever to reduce the load. It is characterized in that the block body contains therein a lever mechanism and a Roberval mechanism by working on the longitudinal side thereof and that the force sensor is coupled to the side of the block body. Although the block body is cut and ground in the side for fabricating the lever mechanism and the Roberval mechanism, it maintains the rectangular parallelepiped outer shape and sufficient mechanical strength, thereby enabling to stably reduce the applied load.

Abstract: The present invention provides a peptide selected from the following (i) and (ii): (i) a peptide having the amino acid sequence represented by SEQ ID NO: 1 in the Sequence Listing; and (ii) a peptide having an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 1 in the Sequence Listing by the conservative amino acid substitution, deletion, addition, or insertion of 1 to (inclusive) amino acids except at the 1st Xaa to the 11th Xaa counting from the amino terminus.

Abstract: A platform scale for weighing an object to be weighed by supporting it by a plurality of load detection sections, wherein the load detection section comprises a load sensor 40 having a block body 42 for transmitting an applied load to a tuning fork vibrator 41 coupled to the block body 42 by reducing the load, a circuit board having fabricated thereon circuitry for converting a signal from the tuning fork vibrator into a digital signal and a sensor case 33 for accommodating the load sensor and the circuit board. The sensor case 33 is made by casting stainless material by a lost wax process and is directly coupled to parallel base frames 20 for maintaining the distance between the base frames. The sensor case has sufficient mechanical strength and also acts as a structural member for the base frames, thereby reducing the number of components and the height of a weighing table.

Abstract: (Problem) To provide a load detection sensor capable of stably weighing a heavy object to be weighed in high precision (Means to solve the problem) The load detection sensor 40 according to the present invention comprises a force sensor 41 including a tuning fork vibrator and a block body 42 that has a rectangular parallelepiped outer shape and transmits an applied load to the force sensor by using a lever to reduce the load. It is characterized in that the block body 42 contains therein a lever mechanism and a Roberval mechanism by working on the longitudinal side thereof and that the force sensor 41 is coupled to the side of the block body 42. Although the block body is cut and ground in the side for fabricating the lever mechanism and the Roberval mechanism, it maintains the rectangular parallelepiped outer shape and sufficient mechanical strength, thereby enabling to stably reduce the applied load.