Abstract: Provided are methods for treatment or prevention of an autoimmune disease that comprise administering a monoclonal antibody or a binding fragment thereof that binds to domain 3 of human LAG-3 and has one or more of the properties described in (ii) to (v), and the properties described in (i) and (vi) below: (i) having in vitro ADCC activity; (ii) reducing the number of LAG-3 positive cells in vivo in low fucose form; (iii) suppressing experimental autoimmune encephalomyelitis in vivo in low fucose form; (iv) binding to human activated T cells; (v) human LAG-3 binds to human major histocompatibility complex class II molecules in the presence of the antibody or the binding fragment thereof; and (vi) the presence of the antibody or the binding fragment thereof allowing human LAG-3 to exert a human T cell suppression function.

Abstract: There is provided a head-rest of a car sheet which is configured to includes: a skin configured to cover a surface of the head-rest; a foamed material filled in the head-rest covered by the skin; and a stay extending to an outside from the skin in which the foamed material is filled, wherein the head-rest has a gate shape by indenting a center portion of a lower surface of the head-rest, and a groove portion is formed at the indented center portion of the gate shape by making end portions of the skin abut against each other, and members which are softer than the skin are seamed to the respective end portions of the skin which abut against each other in the groove portion.

Abstract: There is provided a head-rest of a car sheet which is configured to includes: a skin configured to cover a surface of the head-rest; a foamed material filled in the head-rest covered by the skin; and a stay extending to an outside from the skin in which the foamed material is filled, wherein the head-rest has a gate shape by indenting a center portion of a lower surface of the head-rest, and a groove portion is formed at the indented center portion of the gate shape by making end portions of the skin abut against each other, and members which are softer than the skin are seamed to the respective end portions of the skin which abut against each other in the groove portion.

Abstract: To provide a novel antibody. Provided is a monoclonal antibody or a binding fragment thereof that binds to domain 3 of human LAG-3 and has one or more of the properties described in (ii) to (v), and the properties described in (i) and (vi) below: (i) having in vitro ADCC activity; (ii) reducing the number of LAG-3 positive cells in vivo in low fucose form; (iii) suppressing experimental autoimmune encephalomyelitis in vivo in low fucose form; (iv) binding to human activated T cells; (v) human LAG-3 binds to human major histocompatibility complex class II molecules in the presence of the antibody or the binding fragment thereof; and (vi) the presence of the antibody or the binding fragment thereof allowing human LAG-3 to exert a human T cell suppression function.

Abstract: To provide a novel antibody. Provided is a monoclonal antibody or a binding fragment thereof that binds to domain 3 of human LAG-3 and has one or more of the properties described in (ii) to (v), and the properties described in (i) and (vi) below: (i) having in vitro ADCC activity; (ii) reducing the number of LAG-3 positive cells in vivo in low fucose form; (iii) suppressing experimental autoimmune encephalomyelitis in vivo in low fucose form; (iv) binding to human activated T cells; (v) human LAG-3 binds to human major histocompatibility complex class II molecules in the presence of the antibody or the binding fragment thereof; and (vi) the presence of the antibody or the binding fragment thereof allowing human LAG-3 to exert a human T cell suppression function.

Abstract: With respect to a vehicular seat, a hook member of a seat skin and a seat frame structure that facilitate assembling of the skin of a seat cushion or a seat back to a seat frame are provided. The vehicular seat includes: a seat cushion to be a seating face portion of the seat; and a seat back provided on the rear side of the seat cushion and to be a backrest portion of the seat. At least either of the seat cushion and the seat back includes an engaging member provided at an end of the skin material thereof with one or more protruded portions. The skin material is engaged with the seat frame by fitting the protruded portions on the engaging member into grooves or openings provided in the seat frame of the vehicular seat.

Abstract: To provide a novel antibody. Provided is a monoclonal antibody or a binding fragment thereof that binds to domain 3 of human LAG-3 and has one or more of the properties described in (ii) to (v), and the properties described in (i) and (vi) below: (i) having in vitro ADCC activity; (ii) reducing the number of LAG-3 positive cells in vivo in low fucose form; (iii) suppressing experimental autoimmune encephalomyelitis in vivo in low fucose form; (iv) binding to human activated T cells; (v) human LAG-3 binds to human major histocompatibility complex class II molecules in the presence of the antibody or the binding fragment thereof; and (vi) the presence of the antibody or the binding fragment thereof allowing human LAG-3 to exert a human T cell suppression function.

Abstract: Provided is a resin cover for covering a surface of a structure by being inserted and secured together with a metallic clip into a hole portion formed in the structure, the resin cover is formed with a clip squeezing portion for mounting the metallic clip, the clip squeezing portion is formed with a flexure control rib, and the flexure control rib is formed to restrict the defamation amount of a claw portion formed on the metallic clip to prevent the metallic clip from being pulled back from the hole portion formed in the structure when the metallic clip is urged to be pulled back from the hole portion formed in the structure in the state that the metallic clip mounted on the clip squeezing portion is inserted into the hole portion formed in the structure.

Abstract: A surface skin-fastening structure for a vehicle seat for fastening a surface skin to a framework of a vehicle seat, includes a base member which is integral with the framework, a surface skin-pressing member fitted into the base member, an interlocking member provided to an end of the surface skin, and slits provided to the base member. The base member has an extension section, which is an end edge that makes contact with a reverse surface of the surface skin. The slits extend in linear fashion along the end edge of the base member. With the surface skin covering the end edge of the base member, the interlocking member and the end of the surface skin are inserted into one opening of the slits and pass through the slits to appear from the other opening, and are stopped in a state of surface contact at the base member.

Abstract: [Purpose] To provide a vehicle seat having a garnish attached thereto, which is simplified in structure for easy secure attachment of the garnish to a seat cushion of the seat, and also highly improved as to outer appearance quality of the seat cushion. [Means for Achieving the Purpose] A vehicle seat of the present invention includes: a frame 4 formed from a sheet metal, the frame standing upright in a vertical direction thereof; a garnish 1 engaged with and fitted to the frame 4 so as to cover an outer peripheral surface of that frame; a cushion element 3 supported by the frame 4; and a trim cover element 2 covering the cushion element 3. In this vehicle seat, a terminal end portion 20 of the trim cover element 2 is fixedly secured to an outer surface of the garnish 1.

Abstract: A surface skin-fastening structure for a vehicle seat for fastening a surface skin to a framework of a vehicle seat, includes a base member which is integral with the framework, a surface skin-pressing member fitted into the base member, an interlocking member provided to an end of the surface skin, and slits provided to the base member. The base member has an extension section, which is an end edge that makes contact with a reverse surface of the surface skin. The slits extend in linear fashion along the end edge of the base member. With the surface skin covering the end edge of the base member, the interlocking member and the end of the surface skin are inserted into one opening of the slits and pass through the slits to appear from the other opening, and are stopped in a state of surface contact at the base member.

Abstract: A configuration is adopted such that the shape of a peripheral wall portion of a shell-shaped seat back skeleton can be freely set without being restricted by the presence of brackets, the incidence of warping of the seat back skeleton when a vehicle is involved in a rear-end or head-on collision is reduced, and the seat back skeleton does not lose strength even when brackets are affixed to the seat back skeleton. A seat cushion skeleton 8 and the seat back skeleton 9 are coupled by coupling means 19a, 19b, and the seat back skeleton 9 has a main body 14 facing the back of a seated passenger, and a peripheral wall part 15 provided to the peripheral edge of the main body 14. The main body 14 and the peripheral edge part 15 are formed into an integrated shell shape using a synthetic resin. The coupling means 19a, 19b have first brackets 21a, 21b that are joined to the seat back skeleton 9, the first brackets 21a, 21b being affixed by bonding to the main body 14 of the seat back skeleton 9.

Abstract: Provided is a resin cover for covering a surface of a structure by being inserted and secured together with a metallic clip into a hole portion formed in the structure, the resin cover is formed with a clip squeezing portion for mounting the metallic clip, the clip squeezing portion is formed with a flexure control rib, and the flexure control rib is formed to restrict the defamation amount of a claw portion formed on the metallic clip to prevent the metallic clip from being pulled back from the hole portion formed in the structure when the metallic clip is urged to be pulled back from the hole portion formed in the structure in the state that the metallic clip mounted on the clip squeezing portion is inserted into the hole portion formed in the structure.

Abstract: With respect to a vehicular seat, a hook member of a seat skin and a seat frame structure that facilitate assembling of the skin of a seat cushion or a seat back to a seat frame are provided. The vehicular seat includes: a seat cushion to be a seating face portion of the seat; and a seat back provided on the rear side of the seat cushion and to be a backrest portion of the seat. At least either of the seat cushion and the seat back includes an engaging member provided at an end of the skin material thereof with one or more protruded portions. The skin material is engaged with the seat frame by fitting the protruded portions on the engaging member into grooves or openings provided in the seat frame of the vehicular seat.

Abstract: A vehicle seat incorporating a side airbag includes a seat cushion and a seat back, if an impact is detected at that side of the seat back, the inflator is activated, generating high-pressure gas, the gas gushes in the airbag, inflating the airbag, and the airbag so inflated tears up the sewn part of the seat back, which are positioned at the front part of the vehicle wall side of the seat back, and develops to the side and front of the occupant, isolating the occupant from the vehicle wall and protecting the occupant; and the airbag is secured to the inner side of the side frame on the vehicle wall side, an expansion restriction plate is provided on the inner side of the airbag, and the airbag is sandwiched between the side frame on the vehicle wall side and the expansion restriction plate.

Abstract: A vehicle seat having a seat cushion obtained by covering a cushion-side frame with a trim cover, a seat back obtained by covering a back-side frame with a trim cover, and a reclining apparatus for making it possible to adjust the angle of tilt of the seat back with respect to the seat cushion. The reclining apparatus has a return spring provided on the outside of the frames, a locking mechanism for putting the frames into a locked state or an unlocked state, and an operation lever for switching the state of the locking mechanism. An outside surface of the return spring is covered by the operation lever, and the hazard presented by the return spring is reduced.

Abstract: [Purpose] To provide a vehicle seat having a garnish attached thereto, which is simplified in structure for easy secure attachment of the garnish to a seat cushion of the seat, and also highly improved as to outer appearance quality of the seat cushion. [Means for Achieving the Purpose] A vehicle seat of the present invention includes: a frame 4 formed from a sheet metal, the frame standing upright in a vertical direction thereof; a garnish 1 engaged with and fitted to the frame 4 so as to cover an outer peripheral surface of that frame; a cushion element 3 supported by the frame 4; and a trim cover element 2 covering the cushion element 3. In this vehicle seat, a terminal end portion 20 of the trim cover element 2 is fixedly secured to an outer surface of the garnish 1.

Abstract: A vehicle seat incorporating a side airbag includes a seat cushion and a seat back, if an impact is detected at that side of the seat back, the inflator is activated, generating high-pressure gas, the gas gushes in the airbag, inflating the airbag, and the airbag so inflated tears up the sewn part of the seat back, which are positioned at the front part of the vehicle wall side of the seat back, and develops to the side and front of the occupant, isolating the occupant from the vehicle wall and protecting the occupant; and the airbag is secured to the inner side of the side frame on the vehicle wall side, an expansion restriction plate is provided on the inner side of the airbag, and the airbag is sandwiched between the side frame on the vehicle wall side and the expansion restriction plate.

Abstract: A vehicle seat having a seat cushion obtained by covering a cushion-side frame with a trim cover, a seat back obtained by covering a back-side frame with a trim cover, and a reclining apparatus for making it possible to adjust the angle of tilt of the seat back with respect to the seat cushion. The reclining apparatus has a return spring provided on the outside of the frames, a locking mechanism for putting the frames into a locked state or an unlocked state, and an operation lever for switching the state of the locking mechanism. An outside surface of the return spring is covered by the operation lever, and the hazard presented by the return spring is reduced.