Abstract: The invention provides a method for converting non-methylated cytosine in a single-stranded DNA into uracil by a bisulfite reaction with a high conversion efficiency from non-methylated cytosine into uracil. The invention also provides a method for amplifying the single-stranded DNA in which non-methylated cytosine has been converted into uracil, as well as a method for detecting methylated cytosine in the single-stranded DNA.

Abstract: PROBLEM Provided is a novel cyanine dye derivative with a pyrazole skeleton and an indole skeleton, having high sensitivity performance in a shorter wavelength region as compared with a conventional optical system, and showing high water solubility.

Abstract: The present invention provides piezoelectric surface mount devices in which the area of the mounting terminals is reduced, leading to reduction of manufacturing cost. A piezoelectric device comprises a package base (120) including a bottom surface having a long edge and a short edge and a pair of mounting terminals formed on respective short edges of the package base. The pair of mounting terminals are separated by a predetermined longitudinal distance (X3) and are arranged as close as possible to the longitudinal center line of the package base. The predetermined distance is sufficient to prevent electrical short when mounting the piezoelectric device onto the printed substrate. The maximum width (Z2) of each mounting terminal measured in a direction parallel with the short edges of the package base is less than one half the width of the short edge (Z1).

Abstract: An image heating apparatus includes a hollow image heating roller having a through hole at one axial end portion side thereof; a bearing fitted around the roller; a heat insulating bush fitted around the roller between the roller and the bearing; a retaining ring for preventing the heat insulating bush from moving relative to the roller; an annular spacer provided between the heat insulating bush and the retaining ring, the annular spacer being provided with an inwardly protruded key portion engageable with the through hole.

Abstract: An agent for reducing risk in onset of diseases ascribable to non-dipping circadian profile of blood pressure is provided. This agent is capable of effectively lowering SBP from night to early morning in individuals with non-dipping circadian profile of blood pressure, in particular, normal individuals with normal SBP and DBP among them, and is thus capable of reducing risk in onset, particularly likely in the morning, of diseases caused by circadian variation of blood pressure. The agent is intended for administration to such subjects, and contains a hydrolysate or a concentrate thereof, containing Val-Pro-Pro and Ile-Pro-Pro and obtained by hydrolysis of animal milk protein.

Abstract: An image heating apparatus includes a rotatable heating member of magnetism-adjusted alloy configured to heat a toner image on a sheet; an excitation coil configured to generate a magnetic flux for electromagnetic induction heating of the rotatable heating member; a voltage source configured to supply an AC current to the excitation coil; a rotating mechanism configured to rotate the rotatable heating member at a first peripheral speed in an operation in a first image heating mode and configured to rotate the rotatable heating member at a second peripheral speed lower than the first peripheral speed in an operation in a second image heating mode; and a controller configured to control the voltage source in which a maximum current supplied to the excitation coil in the second image heating mode is smaller than a maximum current supplied to the excitation coil in the first image heating mode.

Abstract: An image heating apparatus includes a roller, a heating portion disposed within the roller, a bearing portion fitted around an end portion of the roller to rotably support the roller, and a retaining ring attached at an axially predetermined position of the roller to restrict the roller from moving in a axial direction of the roller with respect to the bearing portion. The retaining ring includes first and second projections fitted into a hole portion of the roller. Profiles of side surfaces of these first and second projections abutting edges of the hole portion in a circumferential direction are recessed in the circumferential direction.

Abstract: An image heater a hollow heating roller having a hole at an axial end portion thereof; a bearing supporting the heating roller; a heat insulating bush fitted between an outer surface of the heating roller and the bearing; a retaining ring for retaining the heat insulating bush in an axial direction of the heating roller, the retaining ring including a projection engaging with the hole; an annular spacer provided between the retaining ring and the heat insulating bush, wherein the spacer includes a connecting portion having a connecting hole, the retaining ring includes a hooking portion engaging with the connecting hole.

Abstract: The purpose of the present invention is to provide an agglutination enhancer which shows superior agglutination enhancing effect to those of conventional immunoagglutination enhancers, and the present invention relates to an agglutination enhancer for an immunoagglutination measurement method which comprises a polymer having a monomer unit shown by the following general formula [1]: (Wherein R1 represents a hydrogen atom or a methyl group; R2 and R3 independently represent a methyl group or an ethyl group, respectively; X represents —NH— or an oxygen atom; n represents an integer of 1 to 6; and m represents an integer of 1 to 3), and an immunoagglutination measurement method in which, in the coexistence of the above-described agglutination enhancer for immunoagglutination measurement method, an antibody against analyte or an antigen for the analyte is brought into contact with the analyte to cause an antigen-antibody reaction.

Abstract: A subject of the present invention is to provide a measurement method using an internal standard substance in an electrophoresis where an analyte is a protein or a compound. The present invention relates to a measurement method for an analyte by an electrophoresis, characterized in that a peak of the analyte is identified by using as an internal standard substance (1) a combination of a compound I having 3 or more anion groups in a molecule and a compound II where 1 to 3 groups of the anion groups of said compound I have been substituted by cation groups, or (2) a combination of a compound III having 3 or more cation groups in a molecule and a compound IV where 1 to 3 groups of the cation groups of said compound III have been substituted by cation groups.

Abstract: An image heating apparatus includes: an exciting coil; a current applying device configured to apply a high-frequency current to the exciting coil; a rotatable heating member configured to heat a toner image on a recording material at a nip, wherein the rotatable heating member includes a first electroconductive layer for generating heat by electromagnetic induction of magnetic flux from the exciting coil; a rotatable pressing member configured to press-contact the rotatable heating member to form the nip, wherein the rotatable pressing member includes a second electroconductive layer electrically insulated from the first electroconductive layer; and a rectifying element configured to be connected between the second electroconductive layer and the ground in a direction in which a surface potential of the rotatable pressing member has an opposite polarity to a normal charge polarity of a toner.

Abstract: A holding force adjusting apparatus to be attached to a posture holding apparatus having a base, a supporting member which is attached onto the base so that the supporting member freely swings between a standby state where the supporting member does not support a substance on the base and an active state where the supporting member supports the substance in an inclination state, and a swinging support member having a biasing force for returning the supporting member to the standby state when the supporting member is inclined, the holding force adjusting apparatus being designed to adjust a biasing force of the swinging support member, the holding force adjusting apparatus including a weighting detection member for detecting weight of the substance to be placed, and a returning force adjusting member for adjusting the bias force according to a detected weight by the weight detecting means.

Abstract: A posture holding apparatus including, a base onto which a substance is placed, a supporting member being attached onto the base so that the supporting member swings between a standby state and an active state, and a swinging support member having a returning force for returning the supporting member to the standby state, wherein the swinging support member is structured by a swinging member, a biasing member for applying a biasing force to the swinging member to the standby state, a liquid pressure output member for outputting liquid pressure in response to a weight of the substance, and a displacement amount adjusting member, with which a point of action of the biasing force applied from the biasing member to the supporting member is moved in response to the liquid pressure such that a distance from the pivot to the point of action changes.

Abstract: An image heating apparatus includes a coil for generating a magnetic flux by a current flowing therethrough; an image heating member having an electroconductive layer in which an eddy current is produced by the magnetic flux by which heat is generated, the image heating member being effective to heat an image on a recording material; an electroconductive magnetic flux adjusting member movable from a first position and a second position to decrease the eddy current produced in the image heating member by the magnetic flux; a temperature sensor for sensing a temperature of image heating member; electric power control means for control electric power supplied to the coil on the basis of an output of the temperature sensor, wherein the electric power control means changes an electric power condition to be supplied to the coil before start of the movement from the first position to the second position of magnetic flux adjusting member.

Abstract: The present invention relates to a casein hydrolysate containing free amino acids and in vivo indigestible peptides having minimally suppressed in vivo enzymatic digestibility, and expected to express functions, such as hypotensive effect, in living organism, and to a method for preparing such a hydrolysate, and use thereof. The casein hydrolysate of the present invention contains free amino acids and peptides, such as in vivo indigestible peptides including Xaa-Pro and Xaa-Pro-Pro, obtained by hydrolyzing animal milk casein to have an average chain length of not longer than 2.1 in terms of the number of amino acid residues, and has ACE inhibitory activity or hypotensive effect.

Abstract: A cyanine dye derivative having high fluorescence intensity in a short wavelength region, and also a controllable migration velocity by further introducing a quaternary ammonium cation.

Abstract: An object of the present invention is to provide a peptide derivative for determining ?-glucan or endotoxin which allows high sensitivity measurement, and a method for determining ?-glucan and/or endotoxin using the same.

Abstract: An image heating apparatus includes a coil for generating a magnetic flux by a current flowing therethrough; an image heating member having an electroconductive layer in which an eddy current is produced by the magnetic flux by which heat is generated, to heat an image on a recording material; an electroconductive magnetic flux adjusting member movable from a first position and a second position to decrease the eddy current produced in the image heating member by the magnetic flux; a sensor for sensing the temperature of the image heating member; and a controller for controlling electric power supplied to the coil on the basis of an output of the sensor. The controller changes an electric power condition to be supplied to the coil before start of the movement from the first position to the second position of magnetic flux adjusting member.

Abstract: An image heating apparatus includes a hollow image heating roller having a through hole at one axial end portion side thereof; a bearing fitted around the roller; a heat insulating bush fitted around the roller between the roller and the bearing; a retaining ring for preventing the heat insulating bush from moving relative to the roller; an annular spacer provided between the heat insulating bush and the retaining ring, the annular spacer being provided with an inwardly protruded key portion engageable with the through hole.